Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov58310.25208/vdv583ArticlesСтатьиReview ArticleCurrent concepts of genetic variability of genital mycoplasmas and their role in the development of inflammatory diseases of the urogenital systemСовременные представления о генетической вариабельности генитальных микоплазм и их роли в развитии воспалительных заболеваний мочеполовой системыRakhmatullinaM RРахматулинаМ Р

д.м.н., заместитель директора по лечебной работе

rahmatulina@cnikvi.ruKirichenkoS VКириченкоС В

врач-дерматовенеролог подросткового специализированного центра профилактики и лечения инфекций, передаваемых половым путем

State research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian FederationФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России15062013893NO3 (2013)№3 (2013)172511032020Copyright ©; 2013, Rakhmatullina M.R., Kirichenko S.V.Copyright ©; 2013, Рахматулина М.Р., Кириченко С.В.2013Rakhmatullina M.R., Kirichenko S.V.Рахматулина М.Р., Кириченко С.В.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/583

The authors disclose current concepts of the taxonomic and morphologic characteristics of genital mycoplasmas and their role in the development of inflammatory urogenital diseases and reproductive disorders. They also discuss such issues as genetic variability of genital mycoplasmas and possible interrelation with different variants of the clinical course of inflammatory processes in the urogenital tract.

Освещены современные представления о таксономических и морфологических особенностях генитальных микоплазм, их роли в развитии воспалительных заболеваний мочеполовой системы и нарушениях репродуктивной функции. Обсуждаются вопросы генетической вариабельности генитальных микоплазм и ее возможной взаимосвязи с вариантами клинического течения воспалительных процессов урогенитального тракта.

Mycoplasma genitaliumM. hominisU. urealyticumMycoplasma genitaliumM. hominisU. urealyticumgenetic variabilityurogenital diseasesUreaplasma рarvumгенетическая вариабельностьзаболевания урогенитальной системыUreaplasma рarvumRazin S. Mycoplasma taxonomy and ecology. In: Maniloff J, McElhaney R. N., et al. Mycoplasmas: molecular biology and pathogenesis. Washington, D.C: Amer Soc Microbiol; 1992; 3—22.Jensen J.S. Mycoplasma genitalium infections. Dan Med Bull. 2006; 53: 1—27.Teng L.J., Zheng X., Glass J.I. et al. Ureaplasma urealyticum biovar specificity and diversity are encoded in multiple banded antigen gene. J Clin Microbiol 1994, 32, 1464—1469.Harasawa R., Kanamoto Y. Differentiation of two biovars of Ureaplasma urealyticum based on the 16S—23S rRNA intergenic spacer region. J Clin Microbiol 1999, 37(12): 4135—4138.Kong F., Ma Z., James G. et al. Species identification and subtyping of Ureaplasma parvum and Ureaplasma urealyticum using PCR-based assays. J Clin Microbiol 2000, 38(3): 1175—1179.Kong F., Gilbert G.L. Postgenomic taxonomy of human Ureaplasma a case study based on multiple gene sequences. Int J Syst Evolution Microbiol 2004, 54: 1815—1821.Robertson J.A., Stemke G.W., Davis J.W. et al. Proposal of Ureaplasma parvum sp. Nov. and emended description of Ureaplasma urealyticum (Shepard et al. 1974) Robertson et al.2001. Int J Syst Evol Microbiol. 2002, 52: 587—597.Борх-сениус С.Н., Чернова О.А., Чернов В.М., Вонский М.С. Микоплазмы: Молекулярная и клеточная биология, взаимодействие с иммунной системой млекопитающих, патогенность, диагностика. СПб., Наука 2002; 319.Stein M.A., Baseman J.B. The evolving saga of Mycoplasma genitalium. Clin Microbiol Newsletter. 2005; 28: 41—48.Fraser C.M., Gocayne J.D., White O. et al. The minimal gene complement of Mycoplasma genitalium. Science 1995; 270: 397—403.Peterson S.N., Fraser C. M. The complexity of simplicity. Genome Biology. USA 2001: 2.Peterson S.N., Hu P.C., Bott K.F., Hutchison C.A. A survey of the Mycoplasma genitalium genome using random sequencing. J Bacteriol 1993, 175: 7918—7930.Pereyre S., P. Sirand-Pugnet, L. Beven et al. Life on arginine for Mycoplasma hominis: clues from its minimal genome and comparison with other human urogenital mycoplasmas. PLoS Genet. Vol. 5: e1000677. 2009.Smith D. G., Russell W. C., Ingledew W.J. & Thirkell D. Hydrolysis of urea by Ureaplasma urealyticum generates a transmembrane potential with resultant ATP synthesis. J Bacteriol 1993; 175: 3253—3258.Taylor-Robinson D., Jensen J.S. Mycoplasma genitalium: from chrysalis to multicolored butterfly. Clin Microbiol 2011. Rev; 24: 498—514.Wetmore et al. Demographic, behavioural and clinical characteristics of men with nongonococcal urethritis differ by etiology: a case-comparison study. Sex Transm Dis 2011; 38: 180—186.Mena L., Wang X., Mroczkowski T. F., Martin D. H. Mycoplasma genitalium infections in asymptomatic men and men with urethritis attending a sexually transmitted diseases clinic in New Orleans. Clin Infect Dis 2002; 35: 1167—1173.Gaydos C., Maldeis N. E., Hardick A. et al. Mycoplasma genitalium compared to chlamydia, gonorrhoea and trichomonas as an aetiological agent of urethritis in men attending STD clinics. Sex Transm Infect 2009; 85: 438— 440.Hilton J., Azariah S., Reid M. A case-control study of men with non-gonococcal urethritis at Auckland Sexual Health Service: rates of detection of Mycoplasma genitalium. Sex Health 2010; 7: 77—81.Dupin N. et al. Detection and quantification of Mycoplasma genitalium in male patients with urethritis. Clin Infect Dis 2003; 37: 602—605.Gambini D. et al. Mycoplasma genitalium in males with nongonococcal urethritis: prevalence and clinical efficacy of eradication. Sex Transm Dis 2000; 27: 226—229.Johannisson G. et al. Occurrence and treatment of Mycoplasma genitalium in patients visiting STD clinics in Sweden. Int J STD AIDS 2000; 11: 324—326.Totten P.A. et al. Association of Mycoplasma genitalium with nongonococcal urethritis in heterosexual men. J Infect Dis 2001; 183: 269—276.CDC http://www.cdc.gov/StD/treatment/2010/STD-Treat-ment-2010-RR5912.pdfShipitsyna E., Krasnoselskikh T., Zolotoverkhaya E. et al. Sexual behaviours, knowledge and attitudes regarding safe sex, and prevalence of non-viral sexually transmitted infections among attendees of youth clinics in St. Petersburg, Russia. 2012.Manhart L.E., Holmes K.K., Hughes J.P. et al. Mycoplasma genitalium among young adults in the United States: an emerging sexually trans-mitted infection. Am J Public Health 2007; 97: 1118—25.A.J. Jensen, C.R. Kleveland, A. Moghaddam et al. Chlamydia trachomatis, Mycoplasma genitalium and Ureaplasma urealyticum among students in northern Norway. J Eur Acad Dermatol Venereol 2012; 1468—3083.Uno M. et al. Mycoplasma genitalium in the cervices of Japanese women. Sex Transm Dis 1997; 24: 284—286.Högdahl M., Kihlström E. Leucocyte esterase testing of first-voided urine and urethral and cervical smears to identify Mycoplasma genitalium-infected men and women. Int J STD AIDS 2007; 18: 835—838.Gaydos C., Maldeis N.E., Hardick A. et al. Mycoplasma genitalium as a contributor to the multiple etiologies of cervicitis in women attending sexually transmitted disease clinics. Sex Transm Dis 2009; 36: 598—606.Cohen C.R. et al. Association between Mycoplasma genitalium and acute endometritis. Lancet 2002; 359: 765—766.Cohen C.R. et al. Detection of Mycoplasma genitalium in women with laparoscopically diagnosed acute salpingitis. Sex Transm Infect 2005; 81: 463—466.Oakeshott P., et al. Is Mycoplasma genitalium in women the «new chlamydia»? A community-based prospective cohort study. Clin Infect Dis 2010; 51: 1160—1166.Baczynska A. et al. Morphology of human Fallopian tubes after infection with Mycoplasma genitalium and Mycoplasma hominis — in vitro organ culture study. Hum Reprod 2007; 22: 968—979.Witt A., Berger A., Gruber C.J. et al. Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature rupture of the membranes and subsequent cesarean delivery. Am J Obstet Gynecol 2005; 193(5): 1663—1669.Eschenbach D. A. Ureaplasma urealyticum and Premature Birth. Clin Infect Dis 1993; 17: 100—106.Patel M.A., Nyirjesy P. Role of Mycoplasma and Ureaplasma species in female lower genital tract infections. Curr Infect Dis Rep 2010 Nov; 12(6): 417—22.Yamazaki T., Matsumoto M., Matsuo J. et al. Frequency of Chlamydia trachomatis in Ureaplasma-positive healthy women attending their first prenatal visit in a community hospital in Sapporo, Japan. BMC Infect Dis 2012; 12: 82. doi: 10.1186/1471-2334-12-82.Kong F., Ma Z., James G. et al. Species identification and subtyping of Ureaplasma parvum and Ureaplasma urealyticum using PCR-based assays. J Clin Microbiol 2000, 38: 1175—1179.De Francesco M.A., Negrini R., Pinsi G. et al. Detection of Ureaplasma biovars and polymerase chain reaction-based subtyping of Ureaplasma parvum in women with or without symptoms of genital infections. Eur J Clin Microbiol Infect Dis 2009; 28: 641—646.Cao X., Wang Y., Hu X. et al. Real-time TaqMan polymerase chain reaction assays for quantitative detection and differentiation of Ureaplasma urealyticum and Ureaplasma parvum. Diagn Microbiol I nfect Dis 2007; 57: 373—378.Zdrodowska-Stefanow B., Kłosowska W.M., Ostaszewska-Puchalska I. et al. Ureaplasma urealyticum and Mycoplasma hominis infection in women with urogenital diseases. Adv Med Scien 2006; 51: 250—253.Nunez-Troconis J.T. Mycoplasma hominis and Ureaplasma urealyticum in different gynecologic diseases. Invest Clin 1999; 40: 9—24.Shigehara K., Kawaguchi S., Sasagawa T. et al. Prevalence of genital Mycoplasma, Ureaplasma, Gardnerella and human papillomavirus in Japanese men with urethritis, and risk factors for detection of urethral human papillomavirus infection. J Infect Chemother 2011; 17(4): 487—492.Yokoi S., Maeda S., Kubota Y. et al. The role of Mycoplasma genitalium and Ureaplasma urealyticum biovar 2 in postgonococcal urethritis. Clin Infect Dis 2007; 45(7): 866—871.Glass J.I., Assad-Garcia N., Alperovich N. et al. Essential genes of a minimal bacterium. Proc Natl Acad Sciences. USA 2006; 103: 425—430.Zhang R., Lin Y. DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes. Nucl Acid Res 2009; 37: 455—458.Taylor-Robinson D. The history and role of Mycoplasma genitalium in sexually transmitted diseases. Genitourin Med 1995; 71: 1—8.Su H., Hutchison C.A., Giddings M.C. Mapping phosphoproteins in Mycoplasma genitalium and Mycoplasma pneumoniae. BMC Microbiol 2007; 7: 63.Ueno P.M., Timenetsky J., Centonze V.E., et al. Interaction of Mycoplasma genitalium with host cells: evidence for nuclear localization. Microbiol 2008; 154: 3033—3041.Glass J.I., Lefkowitz E.J., Glass J.S. et al. The complete sequence of the mucosal pathogen Ureaplasma urealyticum. Nature 2000, 407: 757—762.Pereyre S., Sirand-Pugnet P., Beven L. et al. Life on arginine for Mycoplasma hominis: clues from its minimal genome and comparison with other human urogenital mycoplasmas. PLoS Genet 2009; 5(10): e1000677.Burgos R., Pich O.Q., Ferre-Navarro M. et al. Mycoplasma genitalium P140 and P110 adhesins are reciprocally stabilized and required for cell adhesion and terminal-organelle development. J Bacteriol 2006; 188: 1827—8637.Olson L.D., Renshaw C.A., Shane S.W., Barile M.F. Successive synovial Mycoplasma hominis isolates exhibit apparent antigenic variation. Infect Immun 1991; 59(9): 3327—3329.Razin S., Yogev D., Naot Y. Molecular biology and pathogenicity of mycoplasmas. Microbiol Mol Biol Rev 1998; 62: 1094—1156.Ma L., Jensen J.S. et al. Mycoplasma genitalium: an efficient strategy to generate genetic variation from a minimal genome. Mol Microbiol 2007; 66(1): 220—236.Ma L., Jensen J.S. et al. Genetic Variation in the Complete MgPa Operon and Its Repetitive Chromosomal Elements in Clinical Strains of Mycoplasma genitalium. PLoS One. 2010; 5(12): e15660.Iverson-Cabral S.L., Astete S.G., Cohen C.R. et al. Intrastrain heterogeneity of the mgpB gene in Mycoplasma genitalium is extensive in vitro and in vivo and suggests that variation is generated via recombination with repetitive chromosomal sequences. Infect Immun 2006; 74(7): 3715—3726.Iverson-Cabral S.L., Astete S.G., Cohen C.R., Totten P.A. mgpB and mgpC sequence diversity in Mycoplasma genitalium is generated by segmental reciprocal recombination with repetitive chromosomal sequences. Mol Microbiol 2007; 66(1): 55—73.Ma L., Jensen J.S. et al. Variability of trinucleotide tandem repeats in the MgPa operon and its repetitive chromosomal elements in Mycoplasma genitalium. Med Microbiol 2012; 61: 191—197.Ma L., Taylor S., Jensen J.S. et al. Short tandem repeat sequences in the Mycoplasma genitalium genome and their use in a multilocus genotyping system. BMC Microbiol 2008, 8: 130.Boesen Т., Emmersen J., Baczynska А. et al. The vaa locus of Mycoplasma hominis contains a divergent genetic islet encoding a putative membrane protein. BMC Microbiology 2004; 4: 37.Mardassi B.B., Ayari H., Béjaoui-Khiari A., et al. Genetic variability of the P120' surface protein gene of Mycoplasma hominis isolates recovered from Tunisian patients with uro-genital and infertility disorders. BMC Infect Dis. 2007 Dec 5; 7: 142.Евстигнеева Н.П., Кузнецова Ю.Н., Герасимова Н.М. и соавт. Генетические различия штаммов M. hominis, выделенных от женщин с воспалительными заболеваниями органов малого таза. Вестн дерматол и венерол 2009; 6; 85—90.Чернов В.М., Чернова О.А., Баранова Н.Б. и соавт. Адаптация микоплазм к стрессовым условиям: особенности изменений протеома у Mycoplasma hominis PG37 при голодании и пониженной температуре среды. Молекулярная биология 2011; 45(5): 914—923.Dando S.J., Nitsos I., Kallapur S.G. et al. The role of the multiple banded antigen of Ureaplasma parvum in intraamniotic infection: major virulence factor or decoy? PLoS One. 2012; 7(1): e29856.Waites K.B., Schelonka R.L., Xiao L. et al. Congenital and opportunistic infections: Ureaplasma species and Mycoplasma hominis. Semin Fetal Neonatal Med 2009; 14(3): 190—199.Paralanov V. et al. Comparative genome analysis of 19 Ureaplasma urealyticum and Ureaplasma parvum strains. BMC Microbiol 2012; 12: 88.2180—1288.Kong F., Ma Z., James G. et al. Molecular genotyping of human Ureaplasma species based on multiple-banded antigen (MBA) gene sequences. Int J Syst Evol Microbiol 2000; 50 Pt 5: 1921—1929.