Vestnik dermatologii i venerologiiVestnik dermatologii i venerologii0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov58610.25208/vdv586Research ArticleA case of Kaposi’s sarcoma: using immunohistochemistry studies to identify human herpes virus of the 8th typeRUKSHAT Gtatyana_ruksha@mail.ruAKSENENKOM B-KHORZHEVSKYV A-BEKAZUROVS S-Krasnoyarsk State Medical UniversityKrasnoyarsk Territorial Clinical HospitalKrasnoyarsk Territorial Pathological Anatomy Bureau1510201389511511811032020Copyright © 2013, RUKSHA T.G., AKSENENKO M.B., KHORZHEVSKY V.A., BEKAZUROV S.S.2013The article discusses problems related to optimizing differential diagnostics of Kaposi’s sarcoma using the immunohistochemistry analysis, in particular, identification of human herpes virus of the 8th type being the causative agent of the development of the disease.Kaposi’s sarcomahuman herpes virus of the 8th typeHHV-8immunohistochemistryсаркома Капошивирус герпеса человека 8-го типаиммуногистохимическое исследование[Дерматовенерология, 2010 [под ред. А.А. Кубановой М.: ДЭКС-ПРЕСС, 2010][Chang Y., Cesarman E., Pessin M.S. et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 266: 1865-1869][Ganem D. KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J Clin Invest 2010; 120: 939-949][Weninger W., Partanen T.A., Breiteneder-Geleff S. et al. Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi’s sarcoma tumor cells. Lab Invest 1999; 79: 243-251][Nuovo M., Nuovo J. Utility of HHV8 detection for differentiating Kaposi’s sarcoma from it’s mimics. J Cutan Pathol 2001; 28: 248-255][Patel R.M., Goldblum J.R., Hsi E.D. Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma. Mod Pathol 2004; 17: 456-460]