<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">629</article-id><article-id pub-id-type="doi">10.25208/vdv629</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Systemic antibiotics therapy of acne: certain controversies</article-title><trans-title-group xml:lang="ru"><trans-title>Системная антибиотикотерапия акне: некоторые дискуссионные вопросы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>ARAVIYSKAYA</surname><given-names>YE R</given-names></name><name xml:lang="ru"><surname>АРАВИЙСКАЯ</surname><given-names>Е Р</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры дерматовенерологии с клиникой</p></bio><email>arelenar@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>SOKOLOVSKY</surname><given-names>YE V</given-names></name><name xml:lang="ru"><surname>СОКОЛОВСКИЙ</surname><given-names>Е В</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, зав. кафедрой с клиникой</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pavlov State Medical University ot St. Peterburg</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2013</year></pub-date><volume>89</volume><issue>6</issue><issue-title xml:lang="en">NO6 (2013)</issue-title><issue-title xml:lang="ru">№6 (2013)</issue-title><fpage>117</fpage><lpage>121</lpage><history><date date-type="received" iso-8601-date="2020-03-11"><day>11</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, ARAVIYSKAYA Y.R., SOKOLOVSKY Y.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, АРАВИЙСКАЯ Е.Р., СОКОЛОВСКИЙ Е.В.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">ARAVIYSKAYA Y.R., SOKOLOVSKY Y.V.</copyright-holder><copyright-holder xml:lang="ru">АРАВИЙСКАЯ Е.Р., СОКОЛОВСКИЙ Е.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/629">https://vestnikdv.ru/jour/article/view/629</self-uri><abstract xml:lang="en"><p>The article presents intormation about systemic antibiotics treatment ot acne. The authors discuss issues such as indications tor the administration ot antibiotics, drug selection and combination with external drugs.</p></abstract><trans-abstract xml:lang="ru"><p>Приводятся сведения о системной антибактериальной терапии акне. Обсуждаются вопросы показаний для назначения антибиотиков, выбора препарата и сочетания с наружными средствами.</p></trans-abstract><kwd-group xml:lang="en"><kwd>tetracyclines</kwd><kwd>doxycycline</kwd><kwd>minocycline</kwd><kwd>antibiotic resistance</kwd><kwd>combination therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>тетрациклины</kwd><kwd>доксициклин</kwd><kwd>миноциклин</kwd><kwd>антибиотикорезистентность</kwd><kwd>комбинированная терапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Thiboutot D., Gollnick H.P., Bettoli V., Dreno B. et al. New insights into the management of acne: An update from the Global Alliacne to improve outcomes in acne group. JAAD 2009; 60: 5: 1—50</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Аравийская Е.Р., Красносельских Т.В., Соколовский Е.В. Акне. Кожный зуд. Акне. Урогенитальная хламидийная инфекция. Под ред. Е.В. Соколовского. СПб: Сотис, 1998; 68—110</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Самцов А.В. Акне и акнеформные дерматозы. Монография. М: OOO «ЮТКОМ» 2009; 208</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Jeremy A.H., Holland D.B., Roberts S.G., Thomson K.F., Cunliffe W.J. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 2003 Jul; 121(1): 20—7.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Brown S.K., Shalita A.R. Acne vulgaris. Lancet 1998; 351: 1871—1876.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Cunliffe W.J. Acne. London: Martin Dunitz 1988; 392.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Sapadin A.N., Fleischmajer R. Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol 2006; 54(2): 258—65.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Kim J., Ochoa M.T., Krutzik S.R., Takeuchi O. et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 2002; 169(3): 1535—1541.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Webster G.F., Graber E.M. Antibiotic treatment for acne vulgaris. Semin Cutan Med Surg 2008; 27(3): 183—187.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Thielitz A., Gollnick H. Overview of new therapeutic developments for acne. Exp Rev Dermatol 2009; 4: 1: 55—65.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Juhlin L. Lidén S. A quantitative evaluation of the effect of oxytetracycline and doxycycline in acne vulgaris. Br J Dermatol 1969; 81(2): 154—158.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Maibach H. Lebrun-Vignes Second-generation tetracyclines, a dermatologic overview: clinical uses and pharmacology. Cutis 1991; 48(5): 411—417.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Kircik L.H. Doxycycline and minocycline for the management of acne: a review of efficacy and safety with emphasis on clinical implications. J Drugs Dermatol 2010; 9(11): 1407—1411.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Lebrun-Vignes B., Kreft-Jais C., Castot A., Chosidow O. Comparative analysis of adverse drug reactions to tetracyclines: results of a French national survey and review of the literature. BJD 2012; 166: 1333—1341.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Amin K., Riddle C.C., Aires D.J., Schweiger E.S. Common and alternate oral antibiotic therapies for acne vulgaris: a review. J Drugs Dermatol 2007; 6(9): 873—880.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Bundino S., Salomone R., Zina A.M. Clinical evaluation of josamycin in the treatment of acne. G Ital Dermatol Venereol 1989; Nov—Dec: 11—12.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Kus S., Yucelten D., Aytug A. Comparison of efficacy of azithromycin vs. doxycycline in the treatment of acne vulgaris. Clin Exp Dermatol 2005; 30(3): 215—220.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Kubanova A.A. Acne. Clinical Guidelines.M: DEKS-PRESS 2010 [Клинические рекомендации по ведению больных акне. Под ред. А.А. Кубановой. М: ДЭСК-ПРЕСС 2010.]</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Iinuma K., Noguchi N., Nakaminami H., Sasatsu M., Nishijima S., Tsuboi I. Susceptibility of Propionibacterium acnes isolated from patients with acne vulgaris to zinc ascorbate and antibiotics. Clin Cosmet Investig Dermatol 2011; 4: 161—165.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Krautheim A., Gollnick H.P. Acne: topical treatment. Clin Dermatol 2004; 22(5): 398—407.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Oprica C., Nord C.E. Bacteria ESGoARiA. European surveillance study on the antibiotic susceptibility of Propionibacterium acnes. Clin Microbiol Infect 2005; 11: 204—213.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Nishijima S., Kurokawa I., Kawabata S. Sensitivity of Propionibacterium acnes isolated from acne patients: comparative study of antimicrobial agents. J Int Med Res 1996; 24: 473—477.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Ishida N., Nakaminami H., Noguchi N., Kurokawa I. et al. Antimicrobial susceptibilities of Propionibacterium acnes isolated from patients with acne vulgaris. Microbiol Immunol 2008; 52: 621—624.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Schafer F., Fich F., Lam M., Garate C., Wozniak A., Garcia P. Antimicrobial susceptibility and genetic characteristics of Propionibacterium acnes isolated from patients with acne. Int J Dermatol 2013; 52(4): 418—425.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Cooper A. Systematic review of Propionibacterium acnes resistance to systemic antibiotics. Med J Aus 1998; 169: 259—261.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Ross J., Snelling A., Carnegie E. et al. Clinical and laboratory investigations antibiotic-resistant acne: lessons from Europe. Br J Dermatol 2003; 148: 467—478.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Nast A., Dreno B., Bettoli V., Degitz K. et al. European evidence-based (S3) guidelines for the treatment of acne. JEADV 2012; 26; 1: 1—29.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Burke B., Eady E.A., Cunliffe W.J. Benzoyl peroxide versus topical erythromycin in the treatment of acne vulgaris. Brit J Dermatol 1983; 108: 199—204.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Eady E.A., Farmery M.R., Ross J.I., Cove J.H., Cunliffe W.J. Effects of benzoyl peroxide and erythromycin alone and in combination against antibiotic-sensitive and -resistant skin bacteria from acne patients. Brit J Dermatol 1994; 131: 331—336.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Gollnick H.P., Graupe K., Zaumseil R.P. Comparison of combined azelaic acid cream plus oral minocycline with oral isotretinoin in severe acne. Eur J Dermatol 2001; 11: 538—544.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Feldman S.R., Tan J., Poulin Y., Dirschka T. The efficacy of adapalene-benzoyl peroxide combination increases with number of acne lesions. JAAD, article in press: 10.1016/j.jaad.2010.03.036 (published online March 23, 2011).</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Feucht C.L., Allen B.S., Chalker D.K., Smith J.G.Jr. Topical erythromycin with zinc in acne. A double-blind controlled study. JAAD 1980; 3: 5: 483—491.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Gollnick H.P., Draelos Z., Glenn M.J., Rosoph L.A. et al. Adapalene-benzoyl peroxide, a unique fixed-dose combination topical gel for the treatment of acne vulgaris: a transatlantic, randomized, double-blind, controlled study in 1670 patients. Br J Dermatol 2009; 161: 5: 1180—1189.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Habbema L., Koopmans B., Menke H.E., Doornweerd S., De Boulle K. A 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm) in acne vulgaris: a randomized, double-blind comparative study. Br J Dermatol 1989; 121: 4: 497—502.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Leyden J. et al. The combination formulation of clindamycin 1% plus benzoyl peroxide 5% versus 3 different formulations of topical clindamycin alone in the reduction of Propionibacterium acnes. An in vivo comparative study. Am J Clin Dermatol 2001; 2: 263—266.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Leyden J., Preston N., Osborn C., Gottschalk R.W. In-vivo effectiveness of adapalene 0.1%/benzoyl peroxide 2.5% gel on antibiotic-sensitive and resistant propionibacterium acnes. Clin Aesthet Dermatol 2011; 4: 5: 22—26.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Stein Gold L., Cruz A., Eichenfield L., Tan J. et al. Effective and safe combination therapy for severe acne vulgaris: a randomized, vehicle-controlled, doubleblind study of adapalene 0.1 %-benzoyl peroxide 2.5% fixed-dose combination gel with doxycycline hyclate 100 mg. Cutis 2010; 85: 94—104.</mixed-citation></ref></ref-list></back></article>
