Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov72810.25208/vdv728ArticlesСтатьиReview ArticleMethods for revealing therapeutic targets in case of true acantholytic pemphigusМетоды выявления терапевтических мишеней при истинной акантолитической пузырчаткеMICHENKOA VМИЧЕНКОА В

старший научный сотрудник отдела дерматологии

michenko@cnikvi.ruZNAMENSKAYAL FЗНАМЕНСКАЯЛ Ф

к.м.н., заведующая отделом дерматологии

LVOVA NЛЬВОВА Н

д.м.н., профессор, заместитель директора по научно-клинической работе

ROTANOVS VРОТАНОВС В

д.м.н., ведущий научный сотрудник отдела лабораторной диагностики ИППП и болезней кожи

VOLKOVI AВОЛКОВИ А

к.м.н., старший научный сотрудник отдела лабораторной диагностики ИППП и болезней кожи

KATUNINAO RКАТУНИНАО Р

к.м.н., заведующая патоморфологической лабораторией Лабораторного центра

ФГБУ «ГНЦДК» Минздрава РоссииИППП и болезней кожи ФГБУ «ГНЦДК» Минздрава РоссииЛабораторный центр ФГБУ «ГНЦДК» Минздрава России15102012885NO5 (2012)№5 (2012)384311032020Copyright ©; 2012, MICHENKO A.V., ZNAMENSKAYA L.F., LVOV A.N., ROTANOV S.V., VOLKOV I.A., KATUNINA O.R.Copyright ©; 2012, МИЧЕНКО А.В., ЗНАМЕНСКАЯ Л.Ф., ЛЬВОВ А.Н., РОТАНОВ С.В., ВОЛКОВ И.А., КАТУНИНА О.Р.2012MICHENKO A.V., ZNAMENSKAYA L.F., LVOV A.N., ROTANOV S.V., VOLKOV I.A., KATUNINA O.R.МИЧЕНКО А.В., ЗНАМЕНСКАЯ Л.Ф., ЛЬВОВ А.Н., РОТАНОВ С.В., ВОЛКОВ И.А., КАТУНИНА О.Р.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/728

The authors present a review of current approaches to studying the pathogenesis of true acantholytic pemphigus that may reveal new targets for therapeutic treatment. They discuss methods used for the first time to study this lethal dermatosis, and the development of previously used methods that are still important for studying true acantholytic pemphigus.

Представлен обзор современных подходов к изучению патогенеза истинной акантолитической пузырчатки, потенциально позволяющих выявлять новые мишени для терапевтического воздействия. Обсуждаются методы, применяющиеся впервые при изучении данного летального дерматоза, а также развитие ранее применявшихся методов, сохраняющих свою актуальность при изучении истинной акантолитической пузырчатки.

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