Vestnik dermatologii i venerologiiVestnik dermatologii i venerologii0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov74510.25208/vdv745Research ArticleAn open-label prospective clinical study of the efficacy and safety of botulinus toxin type A for the correction of age-related neck skin changesGUBANOVAYE Ielena_gubanova@mail.ruPANOVAO S-SANCHESYE A-RODINAM YU-STAROVATOVAP A-1510201288513414211032020Copyright © 2012, GUBANOVA Y.I., PANOVA O.S., SANCHES Y.A., RODINA M.Y., STAROVATOVA P.A.2012Objective. Assessment of the efficacy and safety of the correction of age-related neck skin changes with the use of botulinus toxin type A (Xeomin). Materials and methods. The study involved 25 women aged 39—65 enrolled according to the inclusion and exclusion criteria. The patients were administered a single subcutaneous injection of Xeomin 60 U in the neck. The efficacy and safety of this procedure was assessed based on the Global Aesthetic Improvement Scale (GAIS) on Day 14 as well as after 2 and 3 months. Results. High efficacy and safety of intracutaneous Xeomin injections at the submaximum dose of 60 u in the medial and lateral platysma bands have been confirmed clinically. The authors suggest an experimental gradining of the age-related neck making it possible to assess and statistically process clinical results of the new method.Inco botulotoxin type Aage-related neck changesneck rejuvenationclassification of neck platysma bandsInco botulotoxin type Aвозрастные изменения шеиомоложение шеиклассификация тяжей платизмы[Середенко Н., Губанова Е.И. Гендерные особенности мотивации к эстетическим процедурам. Эстетическая медицина. 2008; 7 (2): 183—189.][Губанова Е.И., Чернышова М.В., Раннева Е.А., Румянцева Е.Е. Комплексный подход к омоложению нижней трети лица. Проект журнала Le nouvelles Esthetique. 2007. С. 12—15.][Панова О.С., Масюкова С.А., Губанова Е.И., Санчес Е.А. Алгоритм диагностики и лечения инволюционных изменений нижней трети лица. Безопасность нехирургических методик омоложения. 11—15 февраля 2009 г. VIII Международный конгресс по эстетической медицине им. Евгения Лапутина. С. 100—102.][Жукова И. Особенности применения ботулотоксина у возрастных пациентов. Le nouvelles Esthetique 2010; (5): 84—88.][Botulinum toxin: the best practice for the lower face. / Imhof Mattias, MD. 9th anti-aging medicine world congress and medispa, 2011.][Wynn R., Bentsianov B.L., Blitzer A. Botulinum toxin injection for the lower face and neck. Oper. Tech. Otolaryngol. Head and Neck Surg. 2004; (15): 139.][Matarasso W., Zouboulis C.C. Molecular mechanism of skin aging: state of the art. Am. NY. Acad. Sci. 2007; 1119: 40—50.][Prager W., Huber-Vorlander J., Taufig A.Z. et al. Botulinum toxin type A to the upper face: retrospective analysis of daily practice.][Advances in facial rejuvenation: botulinum toxin type A, hyaluronic acid dermal fillers and combination therapies — consensus ecom-mendations. Plast. Reconstr. Surg. 2008. N121 (Suppl.). P. 5S.][Carruthers J., Сarruthes A. Aesthetic botulinum A toxin in the mid and lower face and neck. Dermatol. Surg. 2003; 29: 468—76.][Carruthers A., Сarruthes J. Botulinum toxin type A in the facial aesthetics an update. US Dermatol. Rev. 2006: 69—73.][Carruthers J., Сarruthes A. Complications of botulinum toxin type A. Facial. Plast. Surg. North. Am. 2007; 15: 51.][Carruthers J., Сarruthes A. Botulinum Toxin in Facial Rejuvenation: an Update. Dermatol. Clin. 2009; 27 (4): 417—425.]