<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">7626</article-id><article-id pub-id-type="doi">10.25208/vdv7626</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASE REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЕ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">A rare case of classic Kaposi’s sarcoma with a lesion of the oral mucosa</article-title><trans-title-group xml:lang="ru"><trans-title>Редкий случай классической формы саркомы Капоши с поражением слизистой оболочки полости рта</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2239-7235</contrib-id><contrib-id contrib-id-type="spin">4105-3517</contrib-id><name-alternatives><name xml:lang="en"><surname>Sharova</surname><given-names>Natalia M.</given-names></name><name xml:lang="ru"><surname>Шарова</surname><given-names>Наталья Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>nataliasharova@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7759-5378</contrib-id><name-alternatives><name xml:lang="en"><surname>Smolyannikova</surname><given-names>Vera A.</given-names></name><name xml:lang="ru"><surname>Смольянникова</surname><given-names>Вера Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>smva@bk.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8821-7903</contrib-id><contrib-id contrib-id-type="spin">5240-0869</contrib-id><name-alternatives><name xml:lang="en"><surname>Svishchenko</surname><given-names>Svetlana I.</given-names></name><name xml:lang="ru"><surname>Свищенко</surname><given-names>Светлана Игоревна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н</p></bio><email>svischenko@cnikvi.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-8286-9427</contrib-id><name-alternatives><name xml:lang="en"><surname>Mekhdieva</surname><given-names>Egana S.</given-names></name><name xml:lang="ru"><surname>Мехдиева</surname><given-names>Егана Санановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>dr.mekhdieva@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Prokudina</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Прокудина</surname><given-names>Елена Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>lena_prokudina98@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Apsheva</surname><given-names>Asiyat А.</given-names></name><name xml:lang="ru"><surname>Апшева</surname><given-names>Асият Аверьяновна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>asiyatapsheva@icloud.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">State Research Center of Dermatovenereology and Cosmetology</institution></aff><aff><institution xml:lang="ru">Государственный научный центр дерматовенерологии и косметологии</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский университет)</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-04-20" publication-format="electronic"><day>20</day><month>04</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-05-20" publication-format="electronic"><day>20</day><month>05</month><year>2024</year></pub-date><volume>100</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>80</fpage><lpage>86</lpage><history><date date-type="received" iso-8601-date="2023-04-17"><day>17</day><month>04</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2024-04-09"><day>09</day><month>04</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Sharova N.M., Smolyannikova V.A., Svishchenko S.I., Mekhdieva E.S., Prokudina E.A., Apsheva A.А.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Шарова Н.М., Смольянникова В.А., Свищенко С.И., Мехдиева Е.С., Прокудина Е.А., Апшева А.А.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Sharova N.M., Smolyannikova V.A., Svishchenko S.I., Mekhdieva E.S., Prokudina E.A., Apsheva A.А.</copyright-holder><copyright-holder xml:lang="ru">Шарова Н.М., Смольянникова В.А., Свищенко С.И., Мехдиева Е.С., Прокудина Е.А., Апшева А.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/7626">https://vestnikdv.ru/jour/article/view/7626</self-uri><abstract xml:lang="en"><p>Kaposi’s sarcoma is a systemic tumor multifocal disease of vascular genesis. In the classic Kaposi’s sarcoma, lesions are most often localized on the skin of the lower extremities, lesions of the mucous membranes are extremely rare. The article presents a rare clinical case of the classic Kaposi’s sarcoma in a 56 years old man with lesions of the oral mucosa. This clinical case is of particular interest due to the difficulties of differential diagnosis of Kaposi’s sarcoma and lichen planus when mucous membranes are involved in the pathological process. The presented case emphasizes the importance of a histological examination of the biopsy in differential diagnosis of Kaposi’s sarcoma. In case when the rash is widespread and the mucous membranes are involved, it is recommended to collect the material from the skin, because the histological picture will be more characteristic. It is important to pay attention to the duration of the elements’ existence, as morphological diagnosis in the early stages of Kaposi’s sarcoma can imitate the pattern of chronic dermatosis.</p></abstract><trans-abstract xml:lang="ru"><p>Саркома Капоши — системное опухолевое многоочаговое заболевание сосудистого генеза. При классической форме саркомы Капоши наиболее часто процесс локализуется на коже нижних конечностей, поражение слизистых оболочек встречается крайне редко. В статье описано редкое клиническое наблюдение классической формы саркомы Капоши с поражением слизистой оболочки полости рта у мужчины 56 лет. Данный клинический случай представляет интерес в связи с трудностями дифференциальной диагностики саркомы Капоши и красного плоского лишая при вовлечении в патологический процесс слизистых оболочек. Обозначена важность проведения гистологического исследования для дифференциальной диагностики саркомы Капоши. Учитывая распространенные высыпания, вовлечение слизистых оболочек, рекомендуется взятие биопсийного материала клинических проявлений на гладкой коже, поскольку в этом случае картина будет более характерной. Важно уделять внимание длительности существования элементов, так как морфологические изменения при ранних стадиях саркомы Капоши могут быть сходными с хроническим дерматозом.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Kaposi’s sarcoma</kwd><kwd>neoplastic process</kwd><kwd>angiomatosis</kwd><kwd>lichen planus</kwd><kwd>lesions of the oral mucosa</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>саркома Капоши</kwd><kwd>неопластический процесс</kwd><kwd>ангиоматоз</kwd><kwd>красный плоский лишай</kwd><kwd>поражение слизистой оболочки рта</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Казанцева К.В., Молочков А.В., Молочков В.А., Сухова Т.Е., Прокофьев А.А., Каприн А.Д., и др. Саркома Капоши: патогенез, клиника, диагностика и современные принципы лечения. Российский журнал кожных и венерических болезней. 2015;18(1):7–15. [Kazantseva KV, Molochkov AV, Molochkov VA, Sukhova TE, Prokofyev AA, Kaprin AD, et al. Kaposi’s sarcoma: pathogenesis, clinical picture, diagnosis, and modern therapy. Russian Journal of Skin and Venereal Diseases. 2015;18(1):7–15. (In Russ.)] doi: 10.17816/dv36910</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Каламкарян А.А., Акимов В.Г., Казанцева И.А. Саркома Капоши. Новосибирск: Наука; 1986. 111 c. [Kalamkarjan AA, Akimov VG, Kazanceva IA. Sarkoma Kaposhi., Novosibirsk: Nauka; 1986. 111 s. (In Russ.)]</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Mitsuyasu RT, Groopman JE. Biology and therapy of Kaposi’s sarcoma. Semin Oncol. 1984;11:53–59.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Елькин В.Д., Митрюковский Л.С., Лысов А.Ю. Практическая дерматоонкология: иллюстрированное справочное руководство по опухолям кожи, опухолеподобным заболеваниям и связанным с ними синдромам. М.: Практическая медицина; 2014. 380 с. [El’kin VD, Mitrjukovskij LS, Lysov AJu. Prakticheskaja dermatoonkologija: illjustrirovannoe spravochnoe rukovodstvo po opuholjam kozhi, opuholepodobnym zabolevanijam i svjazannym s nimi sindromam. Moscow: Prakticheskaja medicina; 2014. 480 s. (In Russ.)].</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Молочков А.В., Казанцева И.А., Гурцевич В.Э. Саркома Капоши. М.: БИНОМ-Пресс; 2002. 144 с. [Molochkov AV, Kazanceva IA, Gurcevich VJe. Sarkoma Kaposhi. Moscow: BINOM-Press; 2002. 144 s. (In Russ.)]</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Letang E, Naniche D, Bower M, Miro JM. Kaposi sarcoma-associated immune reconstitution inflammatory syndrome: in need of a specific case definition. Clin Infect Dis. 2012;55(1):157–158. doi: 10.1093/cid/cis308</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Karabajakian A, Ray-Coquard I, Blay JY. Molecular Mechanisms of Kaposi Sarcoma Development. Cancers (Basel). 2022;14(8):1869. doi: 10.3390/cancers14081869</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Gao SJ, Kingsley L, Li M, Zheng W, Parravicini C, Ziegler J, et al. KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi’s sarcoma. Nat Med. 1996;2(8):925–928. doi: 10.1038/nm0896-925</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Calabrò ML, Sheldon J, Favero A, Simpson GR, Fiore JR, Gomes E, et al. Seroprevalence of Kaposi’s sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy. J Hum Virol. 1998;1(3):207–213.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Fu B, Sun F, Li B, Yang L, Zeng Y, Sun X, et al. Seroprevalence of Kaposi’s sarcoma-associated herpesvirus and risk factors in Xinjiang, China. J Med Virol. 2009;81(8):1422–1431. doi: 10.1002/jmv.21550</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Gao SJ, Kingsley L, Hoover DR, Spira TJ, Rinaldo CR, Saah A, et al. Seroconversion to antibodies against Kaposi’s sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi’s sarcoma. N Engl J Med. 1996;335(4):233–241. doi: 10.1056/NEJM199607253350403</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Cottoni F, Masala MV, Piras P, Montesu MA, Cerimele D. Mucosal involvement in classic Kaposi’s sarcoma. Br J Dermatol. 2003;148(6):1273–1274. doi: 10.1046/j.1365-2133.2003.05359.x</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Gaertner E, Elstein W. Lichen planus pigmentosus-inversus: case report and reviw of an anusual entity. Dermatol. Online J. 2012;18(2):11.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Jung YJ, Lee YH, Lee SY, Lee WS. A case of lichen planus рegmentosus-inversus in a Korean patient. Ann Dermatol. 2011;23(1):61–63. doi: 10.5021/ad.2011.23.1.61</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Молочкова Ю.В. Пигментный красный плоский лишай. Российский журнал кожных и венерических болезней. 2013;16(3):34–35. [Molochkova YuV. Lichen ruber planus pigmentosus. Rossijskij zhurnal kozhnyh i venericheskih boleznej. 2013;16(3):34–35. (In Russ.)]</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Elder DE, Elenitsas R, Rosenbach M, et al. Lever’s Histopathology of the Skin. 11th ed. Philadelphia, USA: LWW; 2014. P. 1033–1038.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Patel RM, Goldblum JR, Hsi ED. Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma. Mod Pathol. 2004;17(4):456–460. doi: 10.1038/modpathol.3800061</mixed-citation></ref></ref-list></back></article>
