Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov77210.25208/vdv772ArticlesСтатьиInhibitors of tumor necrosis factor-alpha for treatment ofpsoriatic patientsПрепараты ингибиторов фактора некроза опухолейальфа в терапии больных псориазомZnamenskayaL FЗнаменскаяЛ Ф

заведующая отделом дерматологии; к.м.н; ФГУ «ГНЦД Росмедтехнологий»

znaml@cnikvi.ruZnamenskayaL FФГУ «ГНЦД Росмедтехнологий»15122010866NO6 (2010)№6 (2010)71511032020Copyright ©; 2010, Znamenskaya L.F., Znamenskaya L.F.Copyright ©; 2010, Знаменская Л.Ф., Znamenskaya L.F.2010Znamenskaya L.F., Znamenskaya L.F.Знаменская Л.Ф., Znamenskaya L.F.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/772

The article describes current concepts of the role of cytokines in the pathogenesis of inflammatory diseases. The authors describe the biological action of tumor necrosis factor-alpha and its soluble receptors on body cells. They also provide data on the role of tumor necrosis factor-alpha in the formation of skin and joint inflammatory affections at psoriasis. The authors substantiate treatment of medium to severe forms of psoriasis with biological gene-engineered anti-cytokine drugs, and provide and their comparative characteristics.

Изложены современные представления о роли цитокинов в патогенезе воспалительных заболеваний. Описано биологическое действие фактора некроза опухолей альфа и его растворимых рецепторов на клетки организма. Приведены данные об участии фактора некроза опухолей альфа в формировании воспалительных повреждений в коже и суставах при псориазе. Обоснована терапия среднетяжелых и тяжелых форм псориаза биологическими генно-инженерными антицитокиновыми препаратами, дана их сравнительная характеристика.

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