Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov77510.25208/vdv775ArticlesСтатьиTacrolimus: 10 years of successful clinical applicationТакролимус: 10 лет успешного примененияв клинической практикеBakulevA LБакулевА Л

профессор кафедры кожных и венерических болезней, д.м.н; ГОУ ВПО «Саратовскийгосударственный медицинский университет им. В.И. Разумовского»

BakulevA LГОУ ВПО «Саратовскийгосударственный медицинский университет им. В.И. Разумовского»15122010866NO6 (2010)№6 (2010)233811032020Copyright ©; 2010, Bakulev A.L., Bakulev A.L.Copyright ©; 2010, Бакулев А.Л., Bakulev A.L.2010Bakulev A.L., Bakulev A.L.Бакулев А.Л., Bakulev A.L.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/775

Tacrolimus (FK506) is the first drug from the new class of drugs - calcineurin inhibitors. It has a great potential and can change the current approaches to treatment of different dermatoses. Topical forms of Tacrolimus are activated due to the effect on T-lymphocyte signal transduction, and they also inhibit gene transcription. As a result, the T-cell response to antigens is alleviated. Percutaneous absorption of Tacrolimus in affection foci is higher than in healthy skin. Due to this a smaller amount of the drug is absorbed by the skin as long as the skin is healed. Systemic absorption of Tacrolimus is low in the course of treatment. The maximum clinical experience has been gained in the field of applying Tacrolimus for treatment of atopic dermatitis. In a number of clinical studies, 0.03-0.3% Tacrolimus ointment efficiently reduced the severity of symptoms and course of atopic dermatitis in adults and children. Moreover, topical treatment with Tacrolimus did not involve any substantial toxic effects. The patients most often complained of local irritations in the area where the ointment was applied, which were transient by nature and did not demand the drug withdrawal. Today Tacrolimus is a valuable and safer alternative to glucocorticosteroids for treatment of atopic dermatitis. It can also be used for treating other dermatoses, which demands additional all-round examination.

Такролимус (FK506) - первый представитель нового класса лекарственных средств - ингибиторов кальцинейрина, обладающий огромным потенциалом, который открывает возможность изменения существующих подходов к лечению различных дерматозов. Местные формы такролимуса проявляют активность за счет воздействия на пути сигнальной трансдукции в Т-лимфоцитах и ингибируют транскрипцию генов. Следствием этого является снижение Т-клеточного ответа на антигены. Чрескожная абсорбция такролимуса в очагах поражения выше, чем при нанесении на здоровую кожу, в связи с чем по мере выздоровления препарат проникает в кожу все в меньшем количестве. Системная абсорбция такролимуса в ходе лечения незначительна. Наибольший клинический опыт накоплен по применению такролимуса для лечения атопического дерматита. В ряде клинических исследований мазь такролимуса 0,03-0,3% эффективно уменьшала выраженность симптомов и тяжесть течения атопического дерматита у взрослых и детей. Более того, местная терапия такролимусом не сопровождалась сколь-нибудь значительными токсическими эффектами. Наиболее распространенной жалобой пациентов было местное раздражение в области нанесения мази, носившее транзиторный характер и не требовавшее прекращения терапии. На сегодняшний день такролимус является ценной и более безопасной альтернативой глюкокортикостероидам для лечения атопического дерматита, а также имеет потенциал для использования при лечении ряда других дерматозов, что требует дополнительного всестороннего изучения.

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