Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov8110.25208/0042-4609-2014-90-6-57-61SHORT COMMUNICATIONКРАТКИЕ СООБЩЕНИЯNeurotrophins and neuropeptides as inflammatory mediators in case of chronic dermatosisНейротрофины и нейропептиды как медиаторы воспаления при хронических дерматозахKubanovaA. A.КубановаА. А.
Russian Federation
SmolyannikovaV. A.СмольянниковаВ. А.
Russian Federation
ChikinV. V.ЧикинВ. В.
Russian Federation
chikin@cnikvi.ruKaramovaA. E.КарамоваА. Э.
Russian Federation
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian FederationФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава РоссииI.M. Sechenov First Moscow State Medical UniversityГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России24122014906576124082017Copyright ©; 2014, Kubanova A.A., Smolyannikova V.A., Chikin V.V., Karamova A.E.Copyright ©; 2014, Кубанова А.А., Смольянникова В.А., Чикин В.В., Карамова А.Э.2014Kubanova A.A., Smolyannikova V.A., Chikin V.V., Karamova A.E.Кубанова А.А., Смольянникова В.А., Чикин В.В., Карамова А.Э.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/81

This literature review examines the role of neurotrophins and neuropeptides for the development of skin inflammatory reactions in case of chronic inflammatory dermatoses. The article describes inflammatory effects of neurotrophin, a nerve growth factor, neuropeptide substance P and calcitonin gene-related peptide. Factors affecting the condition of skin innervation and development of inflammation - neurotrophin, a nerve growth factor, amphiregulin, an epidermal growth factor, and semaphorin 3A, a nerve repulsion factor - were examined. Searching for and administering antagonists of proinflammatory effects of neuropeptides, neurotrophins and epidermal growth factor can become new approaches to the treatment of chronic inflammatory dermatoses.

В обзоре литературы рассматривается роль нейротрофинов и нейропептидов в развитии воспалительной реакции в коже при хронических воспалительных дерматозах. Описаны воспалительные эффекты нейротрофина фактора роста нервов, нейропептидов субстанции P и пептида, связанного с геном кальцитонина. Рассмотрено участие факторов, влияющих на состояние иннервации кожи и развитие воспаления, - нейротрофина фактора роста нервов и эпидермального фактора роста амфирегулина, фактора редукции нервов семафорина-3А. Поиск и применение антагонистов провоспалительных эффектов нейропептидов, нейротрофинов и эпидермального фактора роста могут быть новым подходом к лечению хронических воспалительных дерматозов.

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