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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">944</article-id><article-id pub-id-type="doi">10.25208/vdv944</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Skin barrier affection mechanisms and methods of their correction with the use of the Emolium series of cosmetic products</article-title><trans-title-group xml:lang="ru"><trans-title>Механизмы нарушений барьерной функции кожи и методы их коррекции косметическими средствами линии «Эмолиум»</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>MONAKHOV</surname><given-names>K N</given-names></name><name xml:lang="ru"><surname>МОНАХОВ</surname><given-names>К Н</given-names></name></name-alternatives><bio xml:lang="ru"><p>профессор кафедры дерматовенерологиид.м.н; Санкт-Петербургский государственный медицинский университет им. Акад. И.П. Павлова</p></bio><email>knmonakhov@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>DOMBROVSKAYA</surname><given-names>D K</given-names></name><name xml:lang="ru"><surname>ДОМБРОВСКАЯ</surname><given-names>Д К</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент каф.общей врачебной практики; Санкт-Петербургский государственный медицинский университет им. Акад. И.П. Павлова</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный медицинский университет им. Акад. И.П. Павлова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2010</year></pub-date><volume>86</volume><issue>2</issue><issue-title xml:lang="en">NO2 (2010)</issue-title><issue-title xml:lang="ru">№2 (2010)</issue-title><fpage>89</fpage><lpage>95</lpage><history><date date-type="received" iso-8601-date="2020-03-11"><day>11</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2010, MONAKHOV K.N., DOMBROVSKAYA D.K.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2010, МОНАХОВ К.Н., ДОМБРОВСКАЯ Д.К.</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="en">MONAKHOV K.N., DOMBROVSKAYA D.K.</copyright-holder><copyright-holder xml:lang="ru">МОНАХОВ К.Н., ДОМБРОВСКАЯ Д.К.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/944">https://vestnikdv.ru/jour/article/view/944</self-uri><abstract xml:lang="en"><p>The article generalizes the current concept of reasons and mechanisms of skin barrier affections, presents a method to correct such affections with the use of Emolium basic skin care products and provides results of the efficacy study of the Emolium cosmetic line along with the glucocorticosteroid therapy in patients suffering from atopic dermatitis.</p></abstract><trans-abstract xml:lang="ru"><p>Обобщены современные представления о причинах и механизмах нарушения кожного барьера, представлены методы коррекции таких нарушений средствами базового ухода за кожей «Эмолиум», приведены результаты исследования эффективности применения косметической линии «Эмолиум» в сочетании с глюкокортикостероидной терапией у больных атопическим дерматитом.</p></trans-abstract><kwd-group xml:lang="en"><kwd>skin barrier</kwd><kwd>atopic dermatitis</kwd><kwd>emollients</kwd><kwd>Emolium</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кожный барьер</kwd><kwd>атопический дерматит</kwd><kwd>эмоленты</kwd><kwd>Эмолиум</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Дерматовенерология: учебник для студ. высш. мед. учеб. заведений / Е.В. Соколовский, Е.Р. Аравийская, К.Н. Монахов и др.; под ред. Е.В. Соколовского. М.: Издательский центр «Академия», 2005. 528 с.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Nilesh Morar, William O.C.M. Cookson, John I. Harper and Miriam F. Moffatt. Filaggrin Mutations in Children with Severe Atopic Dermatitis. Journal of Investigative Dermatology (2007) 127, 1667-1672; doi:10.1038/sj.jid.5700739; published online 15 February 2007.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Белоусова Т.А., Горячкина М.В. Современные представления о структуре и функции кожного барьера и терапевтические возможности коррекции его нарушений // Рус. мед. журн., 2004. Т. 12, № 18. С. 1082-1084.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Fartasch, M. The Epidermal Lamellar Body: A Fascinating Secretory Organelle Journal of Investigativ Dermatology Bibliographic details. 2004. Vol. 122, № 5. P. xi-xii.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Florinda Maria Busi. Barrera epidermica en dermatitis atopica // Rev Asoc Col Dermatol. 2008 (Dee.).Vol. 16, № 4. P. 293, 301.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Swartzendruber D.C., Wertz P.W., Kitko D.J. et al. Molecular models of the intercellular lipid lamellae in mammalian stratum corneum // J. Invest. Dermatol. 1989. Vol. 92. P. 251-257.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Baran R., Maibach H.I. Textbook of cosmetic Dermatology / Martin Dunitz Ltd. 1998. C. 171-186, 203-224.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Roitman E., Elias P.M. Human stratum corneum lipids: characterization and regional variations // J. Lipid. Res. 1983 Feb. Vol. 24, № 2. P. 120-30.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Fulmer A.W., Kramer G.J. Stratum corneum lipid abnormalities in surfactant-induced dry scaly skin // J. Invest. Dermatol. 1986 May. Vol. 86, № 5. P. 598-602.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Mao-Qiang M. et al. Exogenous non physiological vs physiological lipids: divergent mechanism for correction of permeability barrier dysfunctions // Arch Dermatol. 1995. Vol. 131. P. 809-876.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Goldstein A.M., Abramovits W. Ceramides and the stratum corne- um: structure, function, and new methods to promote repair // Int. J. Dermatol. 2003. Vol. 42, № 4. P. 256-59.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Swartzendruber D.C., Wertz P.W., Kitko D.J., Madison K.C., Downing D.T. Molecular models of the intercellular lipid lamellae in mammalian stratum corneum // J. Invest. Dermatol. 1989 Feb. Vol. 92, № 2. P. 251-7.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Lampe M.A., Burlingame A.L., Whitney J., Williams ML, Brown BE, Roitman E, Elias PM. Human stratum corneum lipids: characterization and regional variations // J. Lipid. Res. 1983 Feb. Vol. 24, № 2. P. 120-30.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Madison К.С. Barrier function of the skin: "la raison d'etre" of the epidermis // J. Invest. Dermatol. 2003. Vol. 121, № 2. P. 231-41.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Sator P.G., Schmidt J.B., Honigsmann H. Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis // J. Am. Acad. Dermatol. 2003. Vol. 48. P. 352-8.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Arikawa J., Ishibashi M., Kawashima M., Takagi Y., Ichikawa Y., Imokawa G. Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus // J. Invest. Dermatol. 2002. Vol. 119. P. 433-9.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Руководство по дерматокосметологии / Под ред. Е.Р. Аравийской, Е.В. Соколовского. СПб.: ООО «Издательство Фолиант», 2008. 632 с.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Fluhr J.W., Kao J., Jain M., et al. Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity // J. Invest. Dermatol. 2001. Vol. 117, № 1. P. 44-51.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Mao-Qiang M. et al. Fatty acids are required for epidermal permeability barrier function // J. Clin. Invest. 1993. Vol. 92. P. 791-798.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Mao-Qiang M. et al. Exogenous non physiological vs physiological lipids: divergent mechanism for correction of permeability barrier dysfunctions // Arch. Dermatol. 1995. Vol. 131. P. 809-876.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Coderch L., Lopez O., de la Maza A., Parra J.L. Ceramides and skin function // Am. J. Clin. Dermatol. 2003. Vol. 4, № 2. P. 107-29.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Feingold K.R. et al. Cholesterol synthesis is required for cutaneous barrier function in mice // J. Clin. Invest. 1990. Vol. 86. P. 1783-1795.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Wuthrich B. Definition and diagnosis of intrinsic versus extrinsic atopic dermatitis / In: Bieber TaL, DYM. Atopic dermatitis. Marcel Dekker, Inc. 2002. P. 1-20.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Di Nardo A., Wertz P., Giannetti A. et al. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis // Acta Derm. Venereol. 1998. Vol. 78, № 1. P. 27-30.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Fluhr J.W., Elias P.M. Stratum corneum pH: formation and function of the 'acid mantle' // Exogenous Dermatology. 2002. Vol. 1, № 4. P. 163-75.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Eberlein-Konig B., Schafer T., Huss-Marp J., et al. Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children // Acta Derm. Venereol. 2000. Vol. 80, № 3. P. 188-91.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Food allergy, dermatologic diseases, and anaphylaxis PRACTALL Consensus Report Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology / American Academy of Allergy, Asthma and Immunology / PRACTALL Consensus Report Cezmi A. Akdis, MD, a Mu E. beccel Akdis, MD, PhD, a Thomas Bieber, MD, PhD, b Carste 2006 American Academy of Allergy, Asthma and Immunology and the European Academy of Allergology and Clinical Immunology doi:10.1016/j.jaci.2006.03.045n.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Rippke F., Schreiner V., Doering T., Maibach H.I. Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with Staphylococcus aureus // Am. J. Clin. Dermatol. 2004. Vol. 5. P. 217-23.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Vasilopoulos Y., Cork M.J., Murphy R., Williams H.C., Robinson D.A., Duff G.W. et al. Genetic association between an AACC insertion in the 39UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis // J. Invest. Dermatol. 2004. Vol. 123. P. 62-6.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Alan D. Irvine, McLean Breaking the (Un)Sound Barrier: Filaggrin Is a Major Gene for Atopic Dermatitis // J. Invest. Dermatol. 2006. Vol. 126. P. 1200-1202.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Sandilands A., Terron-Kwiatkowski A., Hull P.R. et al.: Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema // Nat. Genet. 2007. Vol. 39. P. 650-654.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Hoffjan S.; S. Stemmler. On the Role of the Epidermal Differentiation Complex in Ichthyosis Vulgaris, Atopic Dermatitis and Psoriasis // Br. J. Dermatol. 2007. Vol. 157, № 3. P. 441-449.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>McGrath J.A.; Uitto J. The filaggrin story: novel insights into skin- barrier function and disease // Trends. Mol. Med. 2008. Vol. 14, № 1. P. 20-7.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>O'Regan G.M., Sandilands A., McLean W.H., Irvine A.D.: Filaggrin in atopic dermatitis // J. Allergy Clin. Immunol. 2008 (Epub ahead of print).</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Henderson J., Northstone K., Lee S. et al.: The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study // J. Allergy Clin. Immunol. 2008. Vol. 121. P. 872-877.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Weidinger S., O'Sullivan M., Illig T. et al.: Filaggrin mutations, atopic eczema, hay fever, and asthma in children // J. Allergy Clin. Immunol. 2008. Vol. 121. P. 1203-1209.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Brown S., Irvine A. Atopic eczema and the filaggrin story // Semin. Cutan. Med. Surg. 2008. Vol. 27. P. 128-137.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Stephan Weidinger, MD, Maureen O'Sullican, MD, Thomas Illig, PhD, Hansjцrg Baurecht, MSc, Martin Depner, MSc, Elke Rodriguez, MSc, Andreas Ruether, PhD, Norman Klopp, PhD, Christian Vogelberg, MD, Stephan K. Weiland, MD, WH Irwin McLean, PhD, DSc, FRSE, Erika von Mutius, MD, Alan D Irvine, MD, Michael Kabesch, MD. Scratching below the surface: Filaggrin mutations, atopic eczema, hay fever and asthma in children // JACI Highlights. May 2008</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Аравийская Е.Р., Соколовский Е.В. Сухость кожи. Причины и механизмы возникновения. Принципы коррекции // Журн. дерматол. и косметол. 2002. Т. 2. С. 10-13.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Hanofin J.M., Tofte S.J. Update on therapy of atopic dermatitis // J. Allergy. Clin. Immunol. 1999. Vol. 104 (3 Pt 2). P. 123-125.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Монахов К.Н., Холодилова Н.А. Применение препаратов «Эмолиум» при лечении больных атопическим дерматитом // Клин. дерматол. и венерол. 2009. Т. 5.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Adrian M. Goldstein, MD, PhD, and William Abramovits, MD. Ceramides and the stratum corneum: structure, function, and new metods to promote repair // Int. J. Dermatol. 2003. Vol. 42. P. 256-259.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Menon G.K., Feingold K.R., Moser A.H. et al. De novo sterol genesis in the skin. II. Regulation by coetaneous barrier requirements // J. Lipid. Res. 1985. Vol. 26. P. 418-427.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Grubauer G., Elias P.M., Feingold K.R. Transepidermal water loss the signal for recovery of barrier strukture and function // J. Lipid. Res. 1989. Vol. 30. P. 323-333.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Adamski Z., Kaszuba A., Placek W. Wieloosrodkowe badanie skutec- znosci preparatow emoliencyjnych z linii Emolium, informacja naukowa: Nepentes S.A. 2007.</mixed-citation></ref></ref-list></back></article>
