Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov97410.25208/vdv974ArticlesСтатьиMechanism of the biological effect of the tumor necrosis factor-аlpha at psoriasisМеханизм реализации биологического действия фактора некроза опухоли-альфа при псориазеZNAMENSKAYAL FЗНАМЕНСКАЯЛ Ф

заведующий отделом дерматологии, к.м.н; ФГУ «ГНЦДК Минздравсоцразвития России»

znaml@cnikvi.ruYEGOROVAYU YUЕГОРОВАЮ Ю

ординатор; ФГУ «ГНЦДК Минздравсоцразвития России»

ZITNERS VЗИТНЕРС В

ординатор; ФГУ «ГНЦДК Минздравсоцразвития России»

ФГУ «ГНЦДК Минздравсоцразвития России»15042011872NO2 (2011)№2 (2011)131711032020Copyright ©; 2011, ZNAMENSKAYA L.F., YEGOROVA Y.Y., ZITNER S.V.Copyright ©; 2011, ЗНАМЕНСКАЯ Л.Ф., ЕГОРОВА Ю.Ю., ЗИТНЕР С.В.2011ZNAMENSKAYA L.F., YEGOROVA Y.Y., ZITNER S.V.ЗНАМЕНСКАЯ Л.Ф., ЕГОРОВА Ю.Ю., ЗИТНЕР С.В.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/974

Among different cytokines, tumor necrosis factor-аlpha (tumor necrosis factor α, TNF-α) plays a special role in psoriatic immunopathogenesis. Data on this cytokine collected for the recent decades made it possible to create a number of biological drugs blocking TNF-α, which are successfully applied in clinical practice for treating medium to severe psoriasis and psoriatic arthritis. This review presents general information about the cytokine structure and its receptor apparatus, regulation mechanisms of TNF-α synthesis and ways of signal transmission as the basis needed to implement the biological effects of cytokine in the development of psoriatic skin affections.

Среди разнообразных цитокинов особое место в иммунопатогенезе псориаза занимает фактор некроза опухоли-альфа (tumor necrosis factor α, TNF-α). Накопленная за последние десятилетия информация об этом цитокине позволила создать ряд биологических препаратов, блокирующих TNF-α, которые с успехом применяются в клинической практике при лечении среднетяжелых и тяжелых форм псориаза и псориатического артрита. В обзоре представлены основные сведения о структуре самого цитокина и его рецепторного аппарата, о механизмах регуляции синтеза TNF-α, путях передачи сигнала как основе реализации биологических эффектов цитокина в развитии псориатических поражений кожи.

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