Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov97810.25208/vdv978ArticlesСтатьиFunctions of Toll-like receptors as an inborn immunity component and their participation in the pathogenesis of dermatoses of different etiologiesФункции toll-подобных рецепторовкак компонента врожденного иммунитетаи их участие в патогенезе дерматозов различнойэтиологииKATUNINAO RКАТУНИНАО Р

заведующая лабораторией патоморфологии, к.м.н; ФГУ «ГНЦДК Минздравсоцразвития России»

katunina@cnikvi.ruФГУ «ГНЦДК Минздравсоцразвития России»15042011872NO2 (2011)№2 (2011)182511032020Copyright ©; 2011, KATUNINA O.R.Copyright ©; 2011, КАТУНИНА О.Р.2011KATUNINA O.R.КАТУНИНА О.Р.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/978

In addition to serving as a mechanical barrier protecting our organism from the damaging effect of different factors, our skin also takes part in immune reactions developing in case of microbial intervention. Toll-like receptors (TLR) mediating recognition of molecular structures of pathogens are expressed in skin cells of different types initiating the development of adaptive immune reactions when associated with different ligands. The review presents data on the structure and functions of TLR, their localization in skin compartments and their role in the pathogenesis of skin diseases being of infectious etiology and non-infectious origin.

Кожа не только выполняет функции механического барьера, защищающего организм от повреждающего воздействия различных факторов, но и участвует в иммунных реакциях, развивающихся при вторжении микроорганизмов. Toll- подобные рецепторы (TLR), опосредующие распознавание молекулярных структур патогенов, экспрессируются в коже на клетках разных типов, инициируя развитие адаптивных иммунных реакций при связывании с различными лигандами. В обзоре приведены данные о строении и функции TLR, их локализации в компартментах кожи, а также об их роли в патогенезе заболеваний кожи инфекционной этиологии и неинфекционного происхождения.

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