Sinus histiocytosis (Rosai-Dorfman disease): a clinical observation
L'vov A.N., Voloshchuk I.N., Varshavskiy V.A., Gorbacheva Y.V., Bobko S.I., LVOV A.N., VOLOSHCHUK I.N., VARSHAVSKY V.A., GORBACHEVA Y.V., BOBKO S.I.
Abstract
The authors characterized a heterogeneous group of a rare disease - Langerhans and non-Langerhans cell histiocytosis,
and analyzed key differential and diagnostic differences between these forms of the disease. A very rare case of non-
Langerhans cell histiocytosis (Rosai-Dorfman disease) in a female patient aged 63 with the subsequent spontaneous
regression of eruptions was described. Key skin manifestations of the Rosai-Dorfman disease included papular eruptions
of the typical intense pink color with a yellowish and brown tint. Morphologic changes were characterized by proliferation
of histiocytes and accumulation of different lipids and pentalamellar markers (S-100 protein, СD 14, СD 68, lysozyme)
in their cytoplasm. Though the Rosai-Dorfman disease usually involves lymph nodes, this case was characterized by
unaffected nodular structures.
and analyzed key differential and diagnostic differences between these forms of the disease. A very rare case of non-
Langerhans cell histiocytosis (Rosai-Dorfman disease) in a female patient aged 63 with the subsequent spontaneous
regression of eruptions was described. Key skin manifestations of the Rosai-Dorfman disease included papular eruptions
of the typical intense pink color with a yellowish and brown tint. Morphologic changes were characterized by proliferation
of histiocytes and accumulation of different lipids and pentalamellar markers (S-100 protein, СD 14, СD 68, lysozyme)
in their cytoplasm. Though the Rosai-Dorfman disease usually involves lymph nodes, this case was characterized by
unaffected nodular structures.