Reasonable selection of a topical therapy for different forms of acne

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Abstract


Modern data of the acne pathogenesis, including the role of Propionibacterium acnes in the early stages of the acne formation and their provocative role in the development of the inflammatory process are presented. Priority importance of topical retinoids and combination products containing fixed combinations adapalene with benzoyl peroxide or antibiotic clindamycin in the acne treatment are shown. There are presented the facts of the effectiveness of Clenzit gel (adapalene 0.1%) and Clenzit-C (adapalene 0.1% and clindamycin phosphate 1.0%) and an algorithm for the choice of drug depending on clinical and morphological features of the skin process that allows to optimize the treatment of patients with various forms of acne.

About the authors

M. M. Kokhan

State budgetary Institution of Sverdlovsk region “Ural research Institute of Dermatovenereology and immunopathology”

Author for correspondence.
Email: antokoff@yandex.ru

Russian Federation

YU. V. Keniksfest

State budgetary Institution of Sverdlovsk region “Ural research Institute of Dermatovenereology and immunopathology”

Email: noemail@neicon.ru

Russian Federation

A. I. Polishchuk

State budgetary Institution of Sverdlovsk region “Ural research Institute of Dermatovenereology and immunopathology”

Email: noemail@neicon.ru

Russian Federation

References

  1. Nast A., Dreno B., Bettoli V. et al. European Evidence-based (S3) Guidelines for the Treatment of Acne. JEADV 2012; 26 (Suppl. 1): 1-29
  2. Кунгуров Н.В., Зильберберг Н.В., Толстая А.И., Кохан М.М. Патогенетическая и клиническая основа результативности комбинированной терапии больных акне и постакне. Лечащий врач 2013; (10): 24-28
  3. Beylot C., Auffret N., Poli F., Claudel J.-P., Leccia M.-T., Del Giudice P., Dreno B. Propionibacterium acnes: an update on its role in the pathogenesis of acne. JEADV 2014; 28: 271-278
  4. Аравийская Е.Р., Соколовский Е.В. Системная антибиотикотерапия акне: некоторые дискуссионные вопросы. Вестн дерматол венерол 2013; (6): 117-121
  5. Nord C.E., Oprica C. Antibiotic resistancein Propionibacterium acnes. Microbiological and clinical aspects. Anaerobe 2006; 12: 207-210.
  6. Thiboutot D., Gollnick H., Bettoli V. et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne Group. J Am Acad. Dermatol 2009; 60 (Suppl 5): 1-50.
  7. Thiboutot D., Dreno B., Gollnick H. et al. A call to limit antibiotic use in acne. J.Drugs Dermatol 2013; 12: 1331-1332.
  8. Gollnick H. P. M. From new findings in acne pathogenesis to new approaches in treatment. JEADV 2015; 29 (Suppl. 5): 1-7.
  9. Dreno B., Thiboutot D., Gollnick H. et al. Large-scale worldwide observational study of adherence with acne therapy. Int J Dermatol 2010; 49: 448-456.
  10. Krakowski A.C., Stendardo S., Eichenfield L.F. Practical considerations in acne treatment and the clinical impact of topical combination therapy. Pediatr Dermatol 2008; 25 (Suppl. 1): 1-14.
  11. Leccia M.T., Auffret N., Poli F., Claudel J.-P., Corvec S., Dreno B. Topical acne treatments in Europe and the issue of antimicrobial resistance. JEADV 2015; 29 (8): 1485-1492.
  12. Thielitz А., Gollnick Н. Topical Retinoids in Acne Vulgaris. Update on Efficacy and Safety. Am J Clin Dermatol 2008; 9 (6): 369-381.
  13. Schmidt N., Gans E.H. Tretinoin: A review of its anti-inflammatory properties in the treatment of acne. J Clin Aesthe tDermatol 2011; 4: 22-29.
  14. Gold L.S. The MORE trial: effectiveness of adapalene gel 0,1% in real-world dermatology practices. Cutis 2006; 78 (1Suppl): 12-18
  15. Del Rosso J.Q., Schmidt N.F. A review of the anti-inflammatory properties of clindamycin in the treatment of acne vulgaris. Cutis 2010; 85: 15-24.
  16. Dreno B. Topical antibacterial therapy for acne vulgaris. Drugs 2004; 64 (21): 2389-2397.
  17. Wolf J.E., Kaplan D., Kraus S.I. et al. Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindomycine: a multi-center randomized, investigator-blind study. JAAD 2003; 49 (suppl.): 211-217.
  18. Thiboutot D., Shalita A., Yamauchi P.S. et al. Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study. Skinmed 2005; 4: 138-146; Е.Р.
  19. Аравийская Е.Р, Соколовский Е.В. Комбинированные препараты в наружном лечении акне: современные данные. Вестн дерматол венерол 2012; (3): 111-114
  20. Thiboutot D.M., Weiss J., Bucko A. et al. Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study. J Am Acad Dermatol 2007; 57: 791-799
  21. Leyden J., Preston N., Osborn C., Gottschalk R.W. In-vivo effectiveness of adapalene 0.1%/ benzoyl peroxide 2.5% gel on antibioticsensitive and resistant Propionibacterium acnes. Clin Aesthet Dermatol 2011; 4 (5): 22-26
  22. Wolf J.E., Kaplan D., Kraus S.J., Rist T., Swinyer L.J., Baker M.D., Liu Y.S., Czernielewski J. Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study. J Am Acad Dermatol 2003; 49 (3 Suppl): 211-217
  23. Jain G.K., Ahmed F.J. Adapalene pretreatment increases follicular penetration of clindamycin: in vitro and in vivo studies. Indian J Dermatol Venereol Leprol 2007; 73 (5): 326-329
  24. Thiboutot D.M., Shalita A.R., Yamauchi P.S., Dawson C., Kerrouche N., Arsonnaud S. Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study. Arch Dermatol 2006; 142; 597-602
  25. Prasad S., Mukhopadhyay A., Kubavat A., Kelkar A., Modi A., Swarnkar B., Bajaj B., Ve damurthy M., Sheikh S., Mittal R. Efficacy and safety of a nano-emulsion gel formulation of adapalene 0.1% and clindamycin 1% combination in acne vulgaris: a randomized, open label, active-controlled, multicentric, phase IV clinical trial. Indian J Dermatol Venereol Leprol 2012; 78 (4): 459-467
  26. Бурцева Г.Н., Сергеев В.Ю. клиническая и видеодерматоскопическая оценка эффективности терапии угревой сыпи. клин дерматол венерол 2012; 2: 87-97

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