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CUTANEOUS MANIFESTATIONS OF ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA
- Authors: Chernova N.G.1, Sinitsyna M.N.1, Sidorova Y.V.1, Soboleva N.P.1, Sudarikov A.B.1, Kovrigina A.M.1, Dvirnyk V.N.1, Zvonkov E.E.1
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Affiliations:
- National Research Center for Hematology, Ministry of Healthcare of the Russian Federation
- Issue: Vol 94, No 2 (2018)
- Pages: 48-56
- Section: CLINICAL PRACTICE GUIDELINES
- URL: https://vestnikdv.ru/jour/article/view/390
- DOI: https://doi.org/10.25208/0042-4609-2018-94-2-48-56
- ID: 390
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Abstract
Background: Angioimmunoblast T-cell lymphoma (AITL) is a rare T-cell lymphoproliferative disease that is accompanied by generalized lymphadenopathy, hepatosplenomegaly, intoxication symptoms and extranodal lesions. The extranodal manifestations of the disease frequently involve various skin changes. One of the first such manifestations is maculopapular rashes observed in about half of AITL patients and usually preceding the appearance of lymphadenopathy. Other forms of skin lesions accompany the disease considerably less frequently.
Aim: To characterize the range of skin changes in patients suffering from AITL, to establish a correspondence between the nature of skin changes and their histological picture.
Materials and methods: 54 AITL patients were being treated at the National Research Centre for Hematology from 2000 to 2017, with the male/female ratio being 30/24. The median age was 61 (29–81) years.
Results: Changes in the skin were observed in 24 (44.4 %) of 54 AITL patients, out of whom 18 (75 %) and 6 (25 %) were male and female patients, respectively. Maculopapular rash was observed in 22 (91.7 %) out of 24 patients. The morphological and molecular investigations of skin biopsy specimens exhibiting maculopapular rash demonstrated nonspecific reactive changes. Patients with maculopapular rash demonstrated an increase in the level of total (polyclonal) IgE. Specific skin lesions detected in 8 (14.8 %) cases were represented by a ‘livedo reticularis’, focal skin hyperpigmentation, erythroderma, left eyelid tumour and tumour in 3, 2, 1, 1 and 1 cases, respectively.
Conclusion: Maculopapular rash frequently observed in AITL patients is a reactive process not associated with a specific skin lesion. Specific skin lesions in AITL are much less common and can be represented by various forms. In some AITL cases, skin changes of the reactive and tumour nature can be simultaneously observed.
About the authors
N. G. Chernova
National Research Center for Hematology, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: ngchernova@mail.ru
Cand. Sci. (Medicine), researcher,
Novy Zykovsky proezd, 4, Moscow, 125167
Russian FederationM. N. Sinitsyna
National Research Center for Hematology, Ministry of Healthcare of the Russian Federation
Email: msini@mail.ru
researcher,
Novy Zykovsky proezd, 4, Moscow, 125167
Russian FederationYu. V. Sidorova
National Research Center for Hematology, Ministry of Healthcare of the Russian Federation
Email: iouliavl@rambler.ru
Cand. Sci. (Medicine), Senior Researcher of Medical Science, researcher,
Novy Zykovsky proezd, 4, Moscow, 125167
Russian FederationN. P. Soboleva
National Research Center for Hematology, Ministry of Healthcare of the Russian Federation
Email: nsoboleva@list.ru
Clinical Laboratory Scientist,
Novy Zykovsky proezd, 4, Moscow, 125167
Russian FederationA. B. Sudarikov
National Research Center for Hematology, Ministry of Healthcare of the Russian Federation
Email: kovrigina.alla@gmail.com
Dr. Sci. (Biology), Head of Laboratory,
Novy Zykovsky proezd, 4, Moscow, 125167
Russian FederationA. M. Kovrigina
National Research Center for Hematology, Ministry of Healthcare of the Russian Federation
Email: dusha@blood.ru
Dr. Sci. (Biology), Head of Laboratory,
Novy Zykovsky proezd, 4, Moscow, 125167
Russian FederationV. N. Dvirnyk
National Research Center for Hematology, Ministry of Healthcare of the Russian Federation
Email: vdvirnyk@mail.ru
Cand. Sci. (Medicine), Dr. Sci. (Biology), Head of Laboratory,
Novy Zykovsky proezd, 4, Moscow, 125167
Russian FederationE. E. Zvonkov
National Research Center for Hematology, Ministry of Healthcare of the Russian Federation
Email: dr.zvonkov@gmail.com
Dr. Sci. (Medicine), Departmental Head,
Novy Zykovsky proezd, 4, Moscow, 125167
Russian FederationReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).