Successful experience in treating primary cutaneous anaplastic large cell lymphoma occuring with common lesions of the skin and lung tissue

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  • Authors: Chernova N.G.1, Badmazhapova D.S.1, Kovrigina A.M.1, Karamova A.E.2, Vorontsova A.A.2, Sinitcina M.N.1, Sidorova Y.V.1, Grebenyuk L.A.1, Nefedova M.A.2, Znamenskaya L.F.2, Zvonkov E.E.1, Savchenko V.G.1
  • Affiliations:
    1. National Research Center for Hematology
    2. State Scientific Center of Dermatovenereology and Cosmetology
  • Issue: Vol 94, No 4 (2018)
  • Pages: 30-42
  • Section: GUIDELINES FOR PRACTITIONERS
  • URL: http://vestnikdv.ru/jour/article/view/421
  • DOI: https://doi.org/10.25208/0042-4609-2018-94-4-30-42

Abstract


The aim of the study is to present a successful case in treating primary cutaneous anaplastic large cell lymphoma (PCALCL) occurring with common lesions of the skin and lung tissue.
Materials and methods. For the verification of the diagnosis in a patient with three types of skin elements (spot, thin plaque with and without ulceration), differential diagnosis was performed between ulcerative pyoderma gangrenosum, PCALCL, large-cell transformation of mycosis fungoides, and secondary skin lesions under the nodal ALK-negtaive ALCL. A complex of studies, including histological, immunohisto - chemical, cytogenetic studies of skin tumor biopsy, allowed the verification of the PCALCL diagnosis. For the treatment of the patient, intensive induction chemotherapy was used followed by high-dose consolidation and autologous transplantation of hematopoietic stem cells.
Results. The selected treatment tactics allowed a long-term complete remission of the disease to be achieved in a patient from the poor prognosis group.
Conclusion. An algorithm for the differential diagnosis and tactics of treating is presented for a patient with primary anaplastic large cell lymphoma with a widespread skin lesion and extradermal foci.


About the authors

N. G. Chernova

National Research Center for Hematology

Author for correspondence.
Email: ngchernova@mail.ru

Russian Federation

Cand. Sci. (Med.), Hematologist Doctor

Zykovsky Novy proezd, 4, Moscow, 125167, Russian Federation

D. S. Badmazhapova

National Research Center for Hematology

Email: darima-doctor@mail.ru

Russian Federation

Post-Graduate Student

Zykovsky Novy proezd, 4, Moscow, 125167, Russian Federation

A. M. Kovrigina

National Research Center for Hematology

Email: kovrigina.alla@gmail.com

Russian Federation

Dr. Sci. (Biol.), Laboratory Head

Zykovsky Novy proezd, 4, Moscow, 125167, Russian Federation

A. E. Karamova

State Scientific Center of Dermatovenereology and Cosmetology

Email: karamova@cnikvi.ru

Russian Federation

Cand. Sci. (Med.), Departmental Head, Department of Dermatology

Korolenko str., 3, building 6, 107076, Moscow, Russian Federation

A. A. Vorontsova

State Scientific Center of Dermatovenereology and Cosmetology

Email: nastasia08@bk.ru

Russian Federation

Junior Researcher, Department of Dermatology

Korolenko str., 3, building 6, 107076, Moscow, Russian Federation

M. N. Sinitcina

National Research Center for Hematology

Email: msini@mail.ru

Russian Federation

Researcher

Zykovsky Novy proezd, 4, Moscow, 125167, Russian Federation

Yu. V. Sidorova

National Research Center for Hematology

Email: iouliavl@rambler.ru

Russian Federation

Cand. Sci. (Med.), Senior Researcher

Zykovsky Novy proezd, 4, Moscow, 125167, Russian Federation

L. A. Grebenyuk

National Research Center for Hematology

Email: lyuba.grebenyuk@yandex.ru

Russian Federation

Leading Molecular Biology Specialist

Zykovsky Novy proezd, 4, Moscow, 125167, Russian Federation

M. A. Nefedova

State Scientific Center of Dermatovenereology and Cosmetology

Email: nefedova.maria.arb@gmail.com

Russian Federation

Junior Researcher, Dapartment of Dermatology

Korolenko str., 3, building 6, 107076, Moscow, Russian Federation

L. F. Znamenskaya

State Scientific Center of Dermatovenereology and Cosmetology

Email: znaml@cnikvi.ru

Russian Federation

Dr. Sci. (Med.), Leading Researcher, Department of Dermatology

Korolenko str., 3, building 6, 107076, Moscow, Russian Federation

E. E. Zvonkov

National Research Center for Hematology

Email: dr.zvonkov@gmail.com

Russian Federation

Dr. Sci. (Med.), Departmental Head

Zykovsky Novy proezd, 4, Moscow, 125167, Russian Federation

V. G. Savchenko

National Research Center for Hematology

Email: director@blood.ru

Russian Federation

RAS Academician, General Director

Zykovsky Novy proezd, 4, Moscow, 125167, Russian Federation

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