An experience of using methylprednisolone aceponate in the therapy of lupus erythematosus tumidus

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Lupus erythematosus tumidus is a rare skin form of lupus erythematosus. About 250 cases of lupus erythematosus tumidus have been described in the world by now. A specific clinical sign of this dermatosis is the appearance of annular or arcuate urticaria-like rash. As a rule, the appearance of the rash is preceded by ultraviolet irradiation. The administration of glucocorticosteroid drugs of local action belonging to classes of potent and very potent steroids is the first-line therapy for lupus erythematosus tumidus. The authors describe a case of the successful treatment of lupus erythematosus tumidus with methylprednisolone aceponate (Advantan ointment) in a female patient aged 56.

About the authors

L. P. Kotrekhova

State budget institution of higher education “North-Western State Medical University named after I.I. Mechnikov” under the Ministry of Public Health of the Russian Federation

Author for correspondence.
Russian Federation

A. A. Vashkevich

State budget institution of higher education “North-Western State Medical University named after I.I. Mechnikov” under the Ministry of Public Health of the Russian Federation

Russian Federation


  1. Kuhn A., Bein D., Bonsmann G. The 100th anniversary of lupus erythematosus tumidus. Autoimmun Rev 2009; 8 (6): 439-532.
  2. Gougerot M., Bournier R. Lupus erythemateux “tumidus”. Bull Soc Fr Derm Syph 1930; 37: 1291-1292.
  3. Stead J., Headley C., loffreda M. et al. Coexistence of tumid lupus erythematosus with systemic lupus erythematosus and discoid lupus erythematosus: a report of 2 cases. J Clin Rheumatol 2008; 14 (6): 338-341.
  4. Manok M. Lupus erythematosus tumidus. Hautarzt 1957; 8: 373-374.
  5. Rock H. Erythematodes tumidus; a case history with reference to the problem of erythematodic lymphocytoma Hautarzt 1954; 5: 422-423.
  6. Vilanova X. The profundus and tumidus forms of lupus erythematosus; report of a case and comments. Rev Clin Esp 1950; 36: 388-393.
  7. Casala A.M., Bianchi C., Bianchi O. Lupus erythematosus tumidus (lymphocytic infiltration of the skin) and chronic lupus erythematosus associated in the same patient. Immunofluorescent study. Bull Soc Fr Dermatol Syphiligr 1971; 78: 256-258.
  8. Mosquera J.C., Torre C., Cruces M.J. Gougerot's lupus erythematosus tumidus. Med Cutan Ibero Lat Am 1984; 12: 425-429.
  9. Schmitt V., Meuth A.M., Amler S. et al. Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosus. Br J Dermatol 2010; 162: 64-73.
  10. Gilliam J.N., Sontheimer R.D. Distinctive cutaneous subsets in the spectrum of lupus erythematosus. J Am Acad Dermatol 1981; 4: 471 -475.
  11. Kozlovskaya V.V., Tikhonovskaya I.V., Kozlovsky V.l. Peculiarities of clinical picture and differential diagnostics of tumour-like lupus erythematosus. Klinicheskaya Meditsina 2013; (4): 65-69.
  12. Antonova O.V., Trofimov P.N., Belousova I.E., Samtsov A.V. Reticular erythematous mucinosis. Vestn Dermatol Venerol 2014; (5): 96-99.
  13. Obermoser G., Sontheimer R.D., Zelger B. Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates. Lupus 2010; 19 (9): 1050-1070.
  14. Remy-Leroux V., Leonard F., Lambert D. Comparison of histopathologic-clinical characteristics of Jessner's lymphocytic infiltration of the skin and lupus erythematosus tumidus: multicenter study of 46 cases. J Am Acad Dermatol 2008; 58 (2): 217-23.
  15. Bonczkowitz M., Weyers W. Differentiation of lupus erythematosus and lymphocytic infiltration. Verh Dtsch Ges Pathol. 1996; 80: 235-240.
  16. Vieira V., Del Pozo J., Yebra-Pimentel M.T. et al. Lupus erythematosus tumidus: a series of 26 cases. Int J Dermatol 2006; 45: 512-517.
  17. Lehrhoff S., Tzu J., Patel R. et al. Lupus erythematosus tumidus with discoid lupus erythema-tosus-induced alopecia of the scalp. Dermatol Online J 2011; 17 (10): 24.
  18. Kuhn A., Richter-Hintz D., Oslislo C. et al. Lupus erythematosus tumidus - a neglected subset of cutaneous lupus erythematosus: report of 40 cases. Arch Dermatol 2000; 136: 1033-1041.
  19. Sonntag M., Lehmann P., Megahed M. et al. Lupus erythematosus tumidus in childhood. Report of 3 patients. Dermatology 2003; 207: 188-192.
  20. Pramatarov K.D. Chronic cutaneous lupus erythematosus - clinical spectrum. Clin Dermatol 2004; 22: 113-120.
  21. Ruiz H., Sanchez J.L. Tumid lupus erythematosus. Am J Dermatopathol 1999; 21 (4): 356-360.
  22. Jolly M., Laumann A.E., Shea C.R., Utset T.O. Lupus erythematosus tumidus in systemic lupus erythematosus: novel association and possible role of early treatment in prevention of discoid lupus erythematosus. Lupus 2004; 13 (1): 64-69.
  23. Alexiades-Armenakas M.R., Baldassano M., Bince B. et al. Tumid lupus erythematosus: criteria for classification with immunohistochemical analysis. Arthritis Rheum 2003; 49: 494-500.
  24. Kuhn A., Sonntag M., Richter-Hintz D. et al. Phototesting in lupus erythematosus: a 15-year experience. J Am Acad Dermatol. 2001; 45: 86-95.
  25. Dekle C.L., Mannes K.D., Davis L.S., Sangueza O.P. Lupus tumidus. J Am Acad Dermatol 1999; 41: 250-253.
  26. Mascaro J.M., Herrero C., Hausmann G. Uncommon cutaneous manifestations of lupus erythematosus. Lupus 1997; 6 (2): 122-131.
  27. Samtsov A.V., Barbinov V.V., Belousova I.E. Tumor-like lupus erythematosus. Vestn Dermatol Venerol 2008; (3): 75-76. Самцов А.В., Барбинов В.В., Белоусова И.Э. Опухолевидная красная волчанка. Вестн. дерматол. венерол. 2008; (3): 75-76.]
  28. Kuhn A., Sonntag M., Ruzicka T. et al. Histopathologic findings in lupus erythematosus tumidus: review of 80 patients. J Am Acad Dermatol 2003; 48: 901-908.
  29. Cozzani E., Christana K., Rongioletti F. et al. Lupus erythematosus tumidus: clinical, histopathological and serological aspects and therapy response of 21 patients. Eur J Dermatol 2010; 20: 797-801.
  30. Choonhakarn C., Poonsriaram A., Chaivoramukul J. Lupus erythematosus tumidus. Int J Dermatol 2004; 43 (11): 815-818.
  31. Chikin V.V. Topical methylprednisolone aceponate and dexpanthenol in the treatment of patients with atopic dermatitis. Vestn Dermatol Venerol 2014; (5): 112-117.

Copyright (c) 2015 Kotrekhova L.P., Vashkevich A.A.

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