Efficiency research of the comprehensive hair loss treatment

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Scope. To determine the therapeutic potency of telogen effluvium complex therapy and androgenetic alopecia. Materials and methods. There are presented results on treatment of 45 patients with telogen hair loss (15 women) and androgenetic alopecia (15 men and 15 women) who were divided into two groups depending on the method of treatment: the main group and the control group. Patients of the main group got pharmaceutical treatment (homeopathic medicine, a L-cysteine + B vitamins preparation) and local therapy (biomimetic peptides-based lotion on the skin of the hairy part of head). The patients in the control group received a similar pharmaceutical treatment but with no applying of biomimetic peptide lotion to the skin of the hairy part of head (scalp). Before and after the therapy the computer-assisted hair and scalp diagnostics were conducted to the fixed zones with permanent marks. The overview photographs of the scalp before the treatment and at follow-up visits were made for the purpose of the follow-up clinical performance evaluation. Results. The computer-assisted hair and scalp diagnostics results analysis of the patients in the study and control groups proved the complex alopecia treatment to be effective.

About the authors

A. A. Kubanov

Russian Medical Academy of Postgraduate Studies, Ministry of Health of the Russian Federation; State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

J. A. Galljamova

Russian Medical Academy of Postgraduate Studies, Ministry of Health of the Russian Federation

Email: noemail@neicon.ru
Russian Federation

O. A. Selezneva

Russian Medical Academy of Postgraduate Studies, Ministry of Health of the Russian Federation

Email: olselezneva83@gmail.com
Russian Federation


  1. Harrison S., Bergfeld W. Diffuse hair loss: its triggers and management. Cleve Clin J Med 2009; 76: 361-7.
  2. Werner B., Mulinari-Brenner F. Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia,telogen effluvium and alopecia areata. Part II. An Bras Dermatol 2012; Nov-Dec; 87 (6): 884-90. Литература
  3. Price V.H. Treatment of hair loss. N Engl J Med 1999; 341 (13): 964-973.
  4. Dinh Q.Q., Sinclair R. Female pattern hair loss: current treatment concepts. Clin Interv Aging 2007; 2 (2): 189-99.
  5. Heilmann S., Kiefer A.K., Fricker N. et al. Androgenetic Alopecia: Identification of Four Genetic Risk Loci and Evidence for the Contribution of WNT Signaling to Its Etiology. Journal of Investigative Dermatology 2013; 133: 1489-1496.
  6. Messenger A.G., de Berker D.A.R., Sinclair R.D. Chapter 66. Disorders of Hair. In: Rook’s Textbook of Dermatology. 8th ed. Oxford, UK: Blackwell Science Publications 2010; 66.1- 66.16.
  7. Headington J.T. Telogen effluvium. New concepts and review. Arch Dermatol 1993 Mar; 129 (3): 356-63.
  8. Rook A., Dawber R. Chapter 5. Diffuse alopecia: endocrine, metabolic and chemical influences on the follicular cycle. In: Rook A., Dawber R., eds. Diseases of the Hair and Scalp. Oxford, UK: Blackwell Science Publications; 1982: 115-145.
  9. Harrison S., Sinclair R. Telogen effluvium. Clin Exp Dermatol 2002; 27: 389-395.
  10. Klaus Volf, Louell A. Goldsmit, Stiven I. Katc. i dr.; per s angl. obshch. red. akad. A.A. Kubanovoi. Dermatologiia Fitcpatrika v klinicheskoi praktike. V 3 T. M.: Izdatelstvo Panfilova; BI-NOM, Laboratoriia znanii; 2012. [Клаус Вольф, Лоуэлл А. Голдсмит, Стивен И. Кац и др.; пер. с англ.; общ. ред. акад. А.А. Кубановой. Дерматология Фицпатрика в клинической практике: В 3 т. М: Издательство Панфилова; БИНОМ. Лаборатория знаний; 2012.]
  11. Blume-Peytavi U., Blumeyer A., Tosti A. et al. S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women and Adolescents. The British Journal of Dermatology 2011; 164 (1): 5-15.
  12. Hamilton J.B. Patterned hair loss in men: types and incidence. Ann NY Acad Sci 1951; 53: 708-14.
  13. Miadeletc O.D., Adaskevich V.P. Morfofunktcionalnaia dermatologiia. M: Medlit; 2006. [Мяделец О.Д., Адаскевич В.П. Морфофункциональная дерматология. М: Медлит; 2006.]
  14. Randall V.A. Hormonal regulation of hair follicles exhibits a biological paradox. Seminars in Cell & Developmental Biology 2007; 18: 274-285.
  15. Kaufman K.D. Androgens and alopecia. Mol Cell Endocrinol 2002; 198: 89-95.
  16. Hebert J.M., Rosenquist T., Gotz J. et al. FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 1994; 78 (6): 1017-25.
  17. Botchkarev V.A., Kishimoto J. Molecular control of epithelial-mesenchymal interactions during hair follicle cycling. J Investig Dermatol Symp Proc 2003; 8: 46-55.
  18. Chih-Chiang Chen, Cheng Ming Chuong. Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia. J Dermatol Sci 2012; 66 (1): 3-11.
  19. Takakura N., Yoshida H., Kunisada T. et al. Involvement of platelet-derived growth factor receptor-alpha in hair canal formation. J Invest Dermatol 1996; 107 (5): 770-7.
  20. Yano K., Oura H. Angiogenesis byVEGF controls hair growth and follicle size. Cell Technol 2001; 20: 852-3.
  21. Paus R., Olsen E.A., Messenger A.G. Hair growth disorders. In: Wolff K., Goldsmith L.A., Katz S.I., Gilchrest B.A., Paller As, Leffell D.J., editors. Fitzpatrick's Dermatology in General Medicine. 7th ed. USA; The McGraw-Hill Companies Inc 2008; 753-77.
  22. Ruchy Jain, Wanchai De-Eknamkul Potential targets in the discovery of new hair growth promoters for androgenic alopecia. Expert Opin Ther Targets 2014; 18 (7).
  23. Al-KHadzh KHassan KHaled. Optimizatciia terapii diffuznoi alopetcii s uchetom narushenii mikrotcirkuliatcii i obmena mikroelementov. Kand diss. M: 2010; 111. [Аль-Хадж Хассан Халед. Оптимизация терапии диффузной алопеции с учетом нарушении микроциркуляции и обмена микроэлементов. Канд. дисс. М: 2010; 111.]
  24. Lengg N., Heidecker B., Seifert B. et al. Dietary supplement increases anagen hair rate in women with telogen effluvium: results of a double-blind, placebo-controlled trial. Therapy 2007; 4 (1): 59-65.
  25. Bohlen P., Esch F., Baird A. et al. Acidic fibroblast growth factor (FGF) from bovine brain: amino-terminal sequence and comparison with basic FGF. EMBO J 1985; 4: 1951-1956.
  26. Kawano M., Komi-Kuramochi A., Asada M. et al. Comprehensive analysis of fgf and fgfr expression in skin: fgf18 is highly expressed in hair follicles and capable of inducing anagen from telogen stage hair follicles. J Invest Dermatol 2005; 124: 877-885.
  27. Kimura-Ueki M., Oda Y., Oki J. et al. Hair cycle resting phase is regulated by cyclic epithelial fgf18 signaling. J Invest Dermatol 2012; 132: 1338-1345.
  28. Ozeki M., Tabata Y. In vivo promoted growth of mice hair follicles by the controlled release of growth factors. Biomaterials 2003; 24: 2387-94.
  29. Tomita Y., Akiyama M., Shimizu H. PDGF isoforms induce and maintain anagen phase of murine hair follicles. J Dermatol Sci 2006; 43: 105-115.
  30. KHavinson V.KH., Kvetnaia T.V. Reguliatornye peptidy i gomeostaz. Rossiiskii khimicheskii zhurnal 2005; XLIX (1): 112-117. [Хавинсон В.Х., Кветная Т.В. Регуляторные пептиды и гомеостаз. Росс хим журн 2005; XLIX (1): 112-117.]
  31. Lupo M.P., Cole A.L. Cosmeceutical peptides. Dermatol Ther 2007 Sep-Oct; 20 (5): 343-9.
  32. Kang Y.A., Na J.I., Choi H.R. et al. Novel anti-inflammatory peptides as cosmeceutical peptides. Peptides 2011 Oct; 32 (10): 2134-6.

Copyright (c) 2016 Kubanov A.A., Galljamova J.A., Selezneva O.A.

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