Naftifine hydrochloride (NH) in the treatment of pityriasis versicolor

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Introduction & objectives: The purpose of this study was to demonstrate the efficacy comparability of 1% NH lotion vs. of 1% NH cream (exoderil, Sandoz) in the treatment of pityriasis versicolor. Material & methods. 71 patients with pityriasis versicolor were randomly allocated either to receive NH lotion once daily (NH lotion group (п = 35, 38.6 years (95% CI [33,7, 43.5]) or NH cream once daily (NH cream group (п = 36, 40.8 years (95% CI [36,6, 45.0]) for 14 days. Mycological evaluations (microscopy and culture) were performed at weeks 2 and 3, inflammation symptoms evaluations were scored at day 3, weeks 2 and 3 after start of the therapy. Overall cure rates assessment included results of mycological, clinical outcomes and safety evaluation. Results. There was no difference between groups in mycological cure rates (94% vs 92%) and inflammation regression (97% vs 97%). Overall cure rate was 91% and 92% of patients in NH lotion and NH cream groups respectively (p = 0,97). Conclusion. 1% NH lotion and 1% NH cream are effective in the treatment of pityriasis versicolor.

About the authors

L. P. Kotrekhova

“North-Western State Medical University named after I.I. Mechnikov”

Author for correspondence.
Russian Federation

A. A. Vashkevich

“North-Western State Medical University named after I.I. Mechnikov”

Russian Federation

E. N. Tsurupa

“North-Western State Medical University named after I.I. Mechnikov”

Russian Federation

P. A. Reztsova

“North-Western State Medical University named after I.I. Mechnikov”

Russian Federation


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Copyright (c) 2016 Kotrekhova L.P., Vashkevich A.A., Tsurupa E.N., Reztsova P.A.

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