DERMATOSCOPY AS A METHOD OF EVALUATING THE EFFICIENCY OF 5% CREAM IMYKVIMOD IN PATIENTS WITH BASAL CELL CARCINOMA OF SKIN

Cover Page

Abstract


The aim. investigation of the possibilities of dermatoscopy as a method for evaluating the effectiveness of therapy with topical imiquimod in patients with superficial basal cell carcinoma (CCB). Materials and methods. the study included 24 patients with a superficial form of CCB, who for various reasons did not undergo excisional surgical intervention and who agreed to alternative drug therapy (officinal original topical imiquimod). Patients were divided into two groups, in which the efficacy of therapy was assessed either by clinical or by dermatoscopic signs. General results. the study demonstrated the importance of dermatoscopy as a method for assessing the effectiveness of therapy with topical imiquimod; Greater prognostic significance of dermatoscopy in comparison with a simple clinical examination of mass when assessing the moment of interruption of drug therapy with imiquimod.

About the authors

M. V. Zhuchkov

Ryazan Regional Clinical Skin and Venereal Diseases Dispensary; Ryazan State Medical University

Author for correspondence.
Email: misha.juchkov@gmail.com

Russian Federation Sport str., 9, Ryazan, 390046, Russia; Vysokovoltnaya str., 9, Ryazan, 390026, Russia

D. B. Sonin

Ryazan Regional Clinical Skin and Venereal Diseases Dispensary

Email: fake@neicon.ru

Russian Federation Sport str., 9, Ryazan, 390046, Russia

M. A.  Tarasova

Ryazan Regional Clinical Skin and Venereal Diseases Dispensary; Ryazan State Medical University

Email: fake@neicon.ru

Russian Federation Sport str., 9, Ryazan, 390046, Russia; Vysokovoltnaya str., 9, Ryazan, 390026, Russia

S. A. Kosorukova

Ryazan State Medical University

Email: fake@neicon.ru

Russian Federation Vysokovoltnaya str., 9, Ryazan, 390026, Russia

References

  1. Lubeek S.F. et al. The Epidemiology and Clinicopathological Features of Basal Cell Carcinoma in Patients 80 Years and Older: A Systematic Review. JAMA Dermatol. 2017 Jan 1; 153 (1): 71—78.
  2. Hogan D.J., To T., Gran L., Wong D., Lane P. R. Risk factors for basal cell carcinoma. Int J Dermatol 1989 Nov; 28 (9): 591—594.
  3. Silapunt S., Chen L., Migden M. R. Hedgehog pathway inhibition in advanced basal cell carcinoma: latest evidence and clinical usefulness. Ther Adv Med Oncol 2016 Sep; 8 (5): 375—82.
  4. Ceilley R. I., Del Rosso J.Q. Current modalities and new advances in the treatment of basal cell carcinoma. Int J Dermatol 2006 May; 45 (5): 489—98.
  5. Gniadecki R. et al. Favourable results of Mohs micrographic surgery for basal cell carcinoma. Dan Med J 2015 Dec; 62 (12): A5171.
  6. Zou Y. et al. Photodynamic therapy versus surgical excision to basal cell carcinoma: metaanalysis. J Cosmet Dermatol 2016 Dec; 15 (4): 374—382.
  7. Piccinno R. et al. Dermatologic radiotherapy in the treatment of extensive basal cell carcinomas: a retrospective study. J Dermatolog Treat 2017 Jan 29: 1—5.
  8. Graells J., Ojeda R.M., García-Cruz A. Effect of imiquimod as compared with surgery on the cancerization field in basal cell carcinoma. Actas Dermosifiliogr. 2014 Jan-Feb; 105 (1): 53—9.
  9. Soong R.S. et al. Toll-like receptor agonist imiquimod facilitates antigen-specific CD8+ T-cell accumulation in the genital tract leading to tumor control through IFNγ. Clin Cancer Res 2014 Nov 1; 20 (21): 5456—5467.
  10. Telò I. et al. Mechanisms of imiquimod skin penetration. Int J Pharm 2016 Sep 10; 511 (1): 516—523.
  11. Kaçar S.D., Özuguz P., Erkan F., Karaca S¸. Treatment of various types of basal cell carcinoma with topical 5% imiquimod in the elderly who refused surgical intervention: a case series. J Dermatolog Treat 2015 Apr; 26 (2): 165—167.

Statistics

Views

Abstract - 641

PDF (Russian) - 263

PlumX

Article Metrics

Metrics Loading ...

Dimensions

Refbacks

  • There are currently no refbacks.

Copyright (c)



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies