Cutaneous sinus histiocytosis of face of the non-Langerhans cell histiocytoses type (cutaneous Rosai — Dorfman disease)

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Abstract


An extremely rare case of sinus histiocytosis of the non-Langerhans cell histiocytoses type is described in 55-year-old patient with isolated localization of cutanious lesion on the right cheek without involvement of nodular structures. Main skin lesion was an erythematous-cyanotic node with multiple milia-like lesions on the top of it. Histologically revealed feature was a large number of plasma cells, besides phenomenon of emperipolesis was described, which was first falsely perceived by pathologists as phagocytosis. In immu-nohistochemistry assay the changes were characterized by proliferation of large polygonal histiocytes with accumulation of pentalamellar markers in its cytoplasm (protein S-100, CD68).


About the authors

E. V. Sokolovsky

Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

Russian Federation

Evgeny V. Sokolovsky — Dr. Sci. (Med.), Prof., Head of Department, Department of Dermatovenereology with a Hospital.

L'va Tolstogo str., bldng 6-8, Saint Petersburg, 197022

G. N. Mikheev

Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

Russian Federation

Georgy N. Mikheev — Cand. Sci. (Med.), Ass. Prof., Department of Dermatovenereology with a Hospital.

L'va Tolstogo str., bldng 6-8, Saint Petersburg, 197022

M. G. Rybakova

Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

Russian Federation

Маrgarita G. Rybakova — Dr. Sci. (Med.), Prof., Head of the Department, Department of Pathological Anatomy with a Pathoanatomical Department.

L'va Tolstogo str., bldng 6-8, Saint Petersburg, 197022

E. B. Manasheva

Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation

Author for correspondence.
Email: volf8989@mail.ru

Russian Federation

Elizaveta B. Manasheva — Medical Resident, Department of Dermatovenereology with a Hospital.

L'va Tolstogo str., bldng 6-8, Saint Petersburg, 197022

V. A. Seredina

Pavlov First Saint Petersburg State Medical University, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

Russian Federation

Vera A. Seredina — Dermatovenerologist, Dermatovenereological Hospital.

L'va Tolstogo str., bldng 6-8, Saint Petersburg, 197022

References

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