Treatment of basal cell cancer in the periorbital area using a pulsed copper vapour laser

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  • Authors: Klyuchareva S.V.1, Ponomarev I.V.2, Topchy S.B.2, Pushkareva A.E.3, Andrusenko Y.N.4
  • Affiliations:
    1. North-Western State Medical University named after I.I. Mechnikov
    2. Lebedev Physical Institute, Russian Academy of Sciences
    3. Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University)
    4. Medical Centre “Institute of Health”
  • Issue: Vol 94, No 6 (2018)
  • Pages: 15-21
  • Section: SCIENTTIFIC RESEARCHES
  • URL: https://vestnikdv.ru/jour/article/view/451
  • DOI: https://doi.org/10.25208/0042-4609-2018-94-6-15-21

Abstract


An increase in life expectancy in developed countries is inevitably accompanied by an increase in the number of nonmelanoma skin diseases, which are primarily represented by basal cell cancer (BCC) occurring in elderly and old-age patients. The pathogenesis of such diseases is associated both with impaired proliferation and differentiation of the keratinocytes of the epidermal basal layer, as well as with the transformation of the vasculature in the papillary dermis in the vicinity of BCC. In recent years, such conditions have been increasingly treated using CO2 , neodymium, diode and pulsed-dye lasers. In many cases, these devices allow malignant BCC cells to be successfully eliminated. However, the use of near-infrared lasers in the periorbital area is limited due to a higher risk of damaging the organs of the visual system. Therefore, a search for new laser surgery methods that can be used for treating malignant skin tumours seems to be a prospective research direction.

Methods. 3 male and 9 female patients diagnosed with primary BCC were treated using a copper vapour laser (Yakhroma-Med). The age of the patients varied from 34 to 77 years. Laser treatment was carried out in one session under the following irradiation parameters: the wavelength of 511 and 578 nm, the average power of up to 3 W and a series of 15 ns pulses. The pause between the pulses was 60 μs, with the exposure time ranging from 200 to 600 ms. The light spot diameter on the skin surface was 1 mm. The follow-up monitoring duration was 24 months.

Results. In all the BCC patients, one session of copper vapour laser treatment allowed malignant cells in the disease area to be completely eliminated without relapses during 2 years after the therapy. The duration of skin healing in the irradiated area was 2 weeks in patients under the age of 40 years, compared to 3–4 weeks in elderly patients. After the treatment, short-term side effects, such as a slight edema, erythema and peeling, were observed.


About the authors

S. V. Klyuchareva

North-Western State Medical University named after I.I. Mechnikov

Email: genasveta@rambler.ru

Russian Federation

Dr. Sci. (Med.), Prof., Department of Dermatovenereology,

Piskarevsky prospect, 47, Saint Petersburg, 195067

I. V. Ponomarev

Lebedev Physical Institute, Russian Academy of Sciences

Author for correspondence.
Email: iponom@okb.lpi.troitsk.ru

Russian Federation

Cand. Sci. (Phys.-Math.), Project manager, 

Leninsky prospekt, 53, Moscow, 119991

S. B. Topchy

Lebedev Physical Institute, Russian Academy of Sciences

Email: fake@neicon.ru

Russian Federation

Cand. Sci. (Phys.-Math.), Senior Researcher, 

Leninsky prospekt, 53, Moscow, 119991

A. E. Pushkareva

Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University)

Email: alexandra.pushkareva@gmail.com

Russian Federation

Cand. Sci. (Engineering), Tutor, Department of Laser Technologies and Systems,

Kronverksky prospect, 49, Saint Petersburg, 197101

Yu. N. Andrusenko

Medical Centre “Institute of Health”

Email: fake@neicon.ru

Ukraine

Surgeon, Oncodermatologist, Head of the Department,

Constitution sq., 26, Kharkov, 61000

References

  1. Huang A., Phillips A., Adar T., and Hui A. Ocular Injury in Cosmetic Laser Treatments of the Face Journal of Clinical and Aesthetic Dermatology. 2018 Feb; 11(2):15–18.
  2. Karabela Y., Eliacik M. Anterior uveitis following eyebrow epilation with alexandrite laser. Int Med Case Rep J. 2015;8:177–179.
  3. Hammes S., Augustin A., Raulin C. et al. Pupil damage after periorbital laser treatment of a port-wine stain. Arch Dermatol. 2007;143(3):392–394.
  4. Chen S. N., Lu C. W., Zhou D. D. A case of accidental retinal injury bycosmetic laser. Eye (Lond). 2014;28(7):906–907.
  5. Park D. H., Kim I. T. A case of accidental macular injury by Nd: YAG laser and subsequent 6 year follow-up. Korean J Ophthalmol. 2009;23(3):207–209.
  6. Lee W. W., Murdock J., Albini T. A., O’Brien T. P., Levine M. L. Ocular damage secondary to intense pulse light therapy to the face. Ophthal Plast Reconstr Surg. 2011;27:263–265. PMID:21346668. doi: 10.1097/IOP.0b013e31820c6e23
  7. Sayed M. S., Ko M. J., Ko A. S., Lee W. W. Ocular damage secondary to lights and lasers: How to avoid and treat if necessary. World J Ophthalmol 2014;4(1):1–6. doi: 10.5318/wjo.v4.i1.1
  8. Дубенский В. В., Гармонов А. А. Современные аспекты эпидемиологии, патогенеза, клиники и лечения базальноклеточного рака кожи. Вестник дерматологии и венерологии. 2004;6:7–12.
  9. Дубенский В. В., Гармонов А. А. Современные аспекты эпидемиологии, патогенеза, клиники и лечения базальноклеточного рака кожи. Вестник дерматологии и венерологии. 2004;6:7–12.
  10. Волгин В. Н., Странадко Е. Ф., Тришкина О. В., Кабанова М. А., Кагоянц Р. В. Сравнительная характеристика различных видов лечения базалиомы кожи. Российский журнал кожных и венерических болезней. 2013;5:4.
  11. Hibler B. P., Sierra H., Cordova M., Phillips W., Rajadhyaksha M., Nehal K. S., Rossi A. M. Carbon dioxide laser ablation of basal cell carcinoma with visual guidance by reflectance confocal microscopy: a proof-of-principle pilot study. Br J Dermatol. 2016 Jun;174(6):1359–1364. doi: 10.1111/bjd.14414
  12. Eimpunth S., Oganesyan G., Hamman M. Sh., Lee R. A., Jiang Sh. I. B., Kim S. S. Effectiveness of a 595-nm pulsed dye laser for the treatment of basal cell carcinoma using stacked-pulse session. Journal of the American Academy of Dermatology. 2014 May;70(5):ab134.
  13. Minars N., Blyumin-Karasik M. Treatment of Basal cell carcinomas with pulsed dye laser: a case series. J Skin Cancer. 2012;2012:286480. doi: 10.1155/2012/286480
  14. Derjabo A., Cema I., Lihacova I., Derjabo L. 980nm laser for difficult-to-treat basal cell carcinoma. Conference: European Conference on Biomedical Optics. May 2013 Proceedings of SPIE — The International Society for Optical Engineering 8803. doi: 10.1117/12.2031532
  15. Ortiz A. E., Anderson R. R., Di Giorgio C., Jiang S. I. B., Shafiq F., Avram M. M. An expanded study of long-pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma. Lasers Surg Med. 2018 Feb 13. doi: 10.1002/lsm.22803
  16. Москалик К. Г., Козлов А. П. Клинические и морфологические факторы в оценке эффективности лечения рака кожи лица импульсным излучением неодимового лазера. Медицинская радиология и радиационная безопасность, 2012;57(5):42–46.
  17. Schuh S., Holmes J., Ulrich M., Themstrup L., Jemec G. B. E., De Carvalho N. et al. Imaging Blood Vessel Morphology in Skin: Dynamic Optical Coherence Tomography as a Novel Potential Diagnostic Tool in Dermatology. Dermatol Ther (Heidelb). 2017;7:187–202.
  18. Stanton A. W. B., Drysdale S. B., Patel R., Mellor R. H., Duff M. J. B., Levick J. R. et al. Expansion of Microvascular Bed and Increased Solute Flux in Human Basal Cell Carcinoma in Vivo, Measured by Fluorescein Video Angiography. Cancer Research. 2003;63:3969–3979.
  19. Писклакова Т. П. Базальноклеточный рак кожи: новые возможности патогенетической терапии. Клиническая дерматология и венерология. 2014;6:4–8.
  20. Shahshahani M. M., Ehsani A., Noormohammadpour P., Hesary K. K., Gholamali F. 595 nm Pulsed Dye Laser: An Alternative to Treat Basal Cell Carcinomas. Journal of Lasers in Medical Sciences. 2011;2(3).
  21. Ключарева С. В., Пономарев И. В., Пушкарева А. Е. Лечение сосудистых мальформаций кожи с применением лазеров на парах меди и импульсного лазера на красителе. Вестник дерматологии и венерологии. 2018;94(1):67–77.
  22. Pushkareva A. E. et al. Laser Phys. 2018;28:096003.
  23. Молочков А. В., Романко Ю. С., Белый Ю. А., Акопова К.В., Третьякова Е. И., Сухова Т. Е. и др. Лазероиндуцированная термотерапия при лечении базалиомы. Клиническая дерматология и венерология. 2012;4:43–47.
  24. Ключарева С. В. Новообразования кожи в офтальмологической практике и современные методы их лечения лазерной установкой на парах меди «Яхрома-Мед». РМЖ «Клиническая офтальмология». 2005;1:23.

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