Naftifine hydrochloride in treatment of foot mycosis complicated with a bacterial infection and significant inflammatory reaction

Goal of the study. To compare the etticacy ot nattitine hydrochloride (Exoderil® cream) and combination cream comprising betamethasone dipropionate, clotrimazole and gentamicin sultate in treatment ot toot mycosis complicated with a bacterial intection and signiticant intlammatory reaction. Materials and methods. A single-center, prospective, randomized, open-label comparative study involved 75 patients aged 23-80 suttering trom toot mycosis complicated with a bacterial intection and signiticant intlammatory reaction. The patients were randomized in two groups. The tirst group comprised 36 patients receiving nattitine hydrochloride while the second one included 39 patients treated with a combination drug comprising betamethasone, clotrimazole and gentamicin. Results. The anti-bacterial etticacy ot nattitine and combination drug comprising betamethasone, clotrimazole and gentamicin was comparable. Complete sanitation ot the bacterial intection was achieved in 94% ot the patients in both groups. The antimycotic etticacy ot nattitine (Exoderil® cream) was reliably higher than that ot the three-component drug to amount to 97% and 82%, respectively (p = 0.03). Complete recovery was achieved in 92% ot the patients treated with nattitine hydrochloride cream and 82% ot the patients treated with the three-component drug (p = 0.22). Conclusion. Exoderil® cream (active substance: nattitine) is a highly etticient drug tor treatment ot ditterent clinical torms ot skin mycosis including those accompanied by a signiticant intlammatory reaction and/or concomitant bacterial intection.

микоз стоп, нафтифина гидрохлорид, бетаметазон, гентамицин, клотримазол, Trichophyton rubrum, бактериальная инфекция, foot mycosis, naftifine hydrochloride, betamethasone, gentamicin, clotrimazole, Trichophyton rubrum, bacterial infection