Immune pathogenesis of psoriasis

Cover Page


Cite item

Full Text

Abstract

The article presents current information about the immune mechanisms of psoriasis. Inflammation in the skin of psoriasis patients is considered as an autoimmune process, in which a key role is played by T-cells sensitized to keratinocytes. One of the most probable self-antigens that trigger an immune inflammation in psoriasis may be cytosolic DNA. We describe the functions of the subpopulations of immune cells and the effects of secreted cytokines in the pathogenesis of psoriasis: the dendritic cells - langerhans cells, plasmacytoid dendritic cells, CD11c+ dendritic cells ; T-cells - T helper type 1 and 17, cytotoxic t lymphocytes, T-regulatory lymphocytes. Important role in the development of relapses of psoriasis is plays a formation in the skin of patients with T-cell memory and intradermal proliferation of T-cells.

About the authors

V. R. Khairutdinov

ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

I. E. Belousova

ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ

Email: noemail@neicon.ru
Russian Federation

A. V. Samtsov

ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ

Email: noemail@neicon.ru
Russian Federation

References

  1. Gudjonsson J.E., Elder J.T. Psoriasis: epidemiology. Clin Dermatol 2007; 25 (6): 535-546.
  2. Chandran V., Raychaudhuri, S.P., 2010. Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J Autoimmun 2010 May; 34 (3): J314-21.
  3. Lowes M.A., Russell C.B., Martin D.A., Towne J.E., Krueger J.G. 2013. The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol 34, 174-181.
  4. Boyman O., Conrad C., Tonel G. et al. The pathogenic role of tissue-resident immune cells in psoriasis. Trends Immunol 2007; 28: 51-7.
  5. Clark R.A. Resident memory T cells in human health and disease. Sci Transl Med 2015 Jan 7; 7 (269): 269rv1.
  6. Hayrutdinov V.R., Mihaylichenko A.F., Piskunova A.L. i dr. Rol CD45RA , CD45RO limfotsitov v patogeneze psoriaza. Ros zhurn kozh i ven bol 2012; 6: 30-5. [Хайрутдинов В.Р., Михайличенко А.Ф., Пискунова А.Л. и др. Роль CD45RA+, CD45RO+ лимфоцитов в патогенезе псориаза. Рос журн кож и вен бол 2012; 6: 30-5.]
  7. Hayrutdinov V.R. Rol immunnoy sistemyi kozhi v patogeneze psoriaza. Immunopatol, allergol, infektol 2012; 2: 54-62. [Хайрутдинов В.Р. Роль иммунной системы кожи в патогенезе псориаза. Иммунопатол, аллергол, инфектол 2012; 2: 54-62.]
  8. Nestle F.O., Conrad C., Tun-Kyi A. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med 2005; 202: 135-143.
  9. Hayrutdinov V.R. Rol CD11c-kletok Rol CD11c-pozitivnyih dendritnyih kletok v patogeneze psoriaza. Vestn dermatol i venerol 2012; 3: 58-64. [Хайрутдинов В.Р. Роль CDHc-клеток Роль CD11c-позитивных дендритных клеток в патогенезе псориаза. Вестн дерматол и венерол 2012; 3: 58-64.]
  10. Lonnberg A.S., Skov L., Skytthe A. et al. Heritability of psoriasis in a large twin sample. Br. J. Dermatol 2013; 169: 412-6.
  11. Tsoi L.C., Spain S.L., Knight J. et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet 2012; 44 (12): 1341-8.
  12. Tang H., Jin X., Li Y. et al. A large-scale screen for coding variants predisposing to psoriasis. Nat Genet 2014; 46 (1): 45-50.
  13. Chandra A., Ray A., Senapati S., Chatterjee R. Genetic and epigenetic basis of psoriasis pathogenesis. Mol Immunol 2015; 64 (2): 313-323.
  14. Weigle N., McBane S. Psoriasis. Am fam Physician. 2013 May 1; 87 (9): 626-33.
  15. Kimball A.B., Leonardi C., Stahle M. et al. Demography, baseline disease characteristics and treatment history of patients with psoriasis enrolled in a multicentre, prospective, disease-based registry (PSOLAR). Br J Dermatol 2014 Jul; 171 (1): 137-47.
  16. Nickoloff B.J., Wrone-Smith T. Injection of prepsoriatic skin with CD4+ T cells induces psoriasis. Am J Pathol 1999; 155 (1): 145-58.
  17. Valdimarsson H., Thorleifsdottir R.H., Sigurdardottir S.L. et al. Psoriasis - as an autoimmune disease caused by molecular mimicry. Trends Immunol 2009 Oct; 30 (10): 494-501.
  18. Besgen P., Trommler P., Vollmer S. Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcalinduced autoimmune response in psoriasis. J Immunol 2010; 184: 5392-402.
  19. fry L., Baker B.S., Powles A.V. et al. Is chronic plaque psoriasis triggered by microbiota in the skin? Br J Dermatol 2013 Jul; 169 (1): 47-52.
  20. Fry L., Baker B.S., Powles A.V., Engstrand L. Psoriasis is not an autoimmune disease? Exp Dermatol 2015 Apr; 24 (4): 241-4.
  21. Sigurdardottir S.L., Thorleifsdottir R.H., Valdimarsson H., Johnston A. The association of sore throat and psoriasis might be explained by histologically distinctive tonsils and increased expression of skin-homing molecules by tonsil T cells. Clin Exp Immunol 2013; 174 (1): 139-51.
  22. Hayrutdinov V.R. Immunogistohimicheskiy analiz kozhi bolnyih psoriazom. Tsitokinyi i vospalenie 2012; 11 (3): 27-34. [Хайрутдинов В.Р. Иммуногистохимический анализ кожи больных псориазом. Цитокины и воспаление 2012; 11 (3): 27-34.]
  23. Dombrowski Y., Peric M., Koglin S. et al. Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci. Transl. Med. 2011; 3: 82ra38.
  24. Paludan S.R., Bowie A.G. Immune sensing of DNA. Immunity. 2013; 38: 870-80.
  25. Chiliveru S., Rahbek S.H., Jensen S.K. et al. Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA. J Immunol 2014; 192 (5): 2395-404.
  26. Lande R., Botti E., Jandus C. The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis. Nat Commun 2014 Dec 3; 5: 5621.
  27. Albanesi C., Scarponi C., Pallotta S. et al. Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J Exp Med 2009; 206: 249-58.
  28. Berthier-Vergnes O., Bermond F., Flacher V. et al. TNF-alpha enhances phenotypic and functional maturation of human epidermal Langerhans cells and induces IL-12 p40 and IP-10/ CXCL-10 production. FEBS Lett 2005; 579: 3660-8.
  29. Krueger J.G., Bowcock A. Psoriasis pathophysiology: current concepts of pathogenesis. Ann Rheum Dis 2005; 64: 1130-6.
  30. Chong S.Z., Wong K.L., Lin G. et al. Human CD8. T cells drive Th1 responses through the differentiation of TNF/iNOS-producing dendritic cells. Eur J Immunol 2011; 41 (6): 1639-51.
  31. Wilsmann-Theis D, Koch S, Mindnich C. et al. Generation and functional analysis of human TNF-a/iNOS-producing dendritic cells (Tip-DC). Allergy 2013 Jul; 68 (7): 890-8.
  32. Campanati A., Orciani M., Consales V. et al. Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis. Arch Dermatol Res 2014 Dec; 306 (10): 915-20.
  33. Fouser L.A., Wright J.F., Dunussi-Joannopoulos K., Collins M. Th17 cytokines and their emerging roles in inflammation and autoimmunity. Immunol Rev 2008; 226: 87-102.
  34. Cargill M., Schrodi S.J., Chang M. et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 2007; 80: 273-90.
  35. Ellinghaus E., Ellinghaus D., Stuart P. et al. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet 2010; 42: 991-5.
  36. Tan J.Y., Li S., Yang K. et al. Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: a meta-analysis. J Dermatolog Treat 2011; 22 (6): 323-36.
  37. Gordon K.B., Leonardi C.L., Lebwohl M. et al. A 52-week, open-label study of the efficacy and safety of ixekizumab, an anti-interleukin-17A monoclonal antibody, in patients with chronic plaque psoriasis. J Am Acad Dermatol 2014; 71 (6): 1176-82.
  38. Mease P.J. Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis. Curr Opin Rheumatol 2015; 27 (2): 127-33.
  39. Acosta-Rodriguez E.V., Rivino L. et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T-helper memory cells. Nat Immunol 2007; 8: 639-46.
  40. Cosmi L, De Palma R, Santarlasci V. et al. Human interleukin-17-producing cells originate from a CD161+ CD4+ T-cell precursor. J Exp Med 2008; 205: 1903-16.
  41. Maggi L., Santarlasci V., Capone M. et al. CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC. Eur J Immunol 2010; 40 (8): 2174-81.
  42. Miossec P., Kolls J.K. Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov 2012; 11: 763-776.
  43. Zhu S, Qian Y. IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential. Clin Sci (Lond) 2012 Jun; 122 (11): 487-511.
  44. Cosmi L., Liotta F., Maggi E. et al. Th17 and non-classic Th1 cells in chronic inflammatory disorders: two sides of the same coin. Int Arch Allergy Immunol 2014; 164 (3): 171-7.
  45. Chan J.R., Blumenschein W., Murphy E. et al. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med 2006; 203: 2577-87.
  46. Hsu H.C., Yang P., Wang J. et al. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol 2008; 9: 166-75.
  47. Rangel-Moreno J., Carragher D.M., Luz Garcia-Hernandez M. et al. The development of inducible bronchus-associated lymphoid tissue depends on IL-17. Nature Immunology 2011; 12: 639-46.
  48. Wong K., Lew F., MacAry P., Kemeny D. CD40L-expressing CD8+ T-cells prime CD8alpha+ DC for IL-12p70 production. Eur J Immunol 2008; 38: 2251-62.
  49. O'Shea J.J., Paul W.E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T-cells. Science 2010; 327 (5969): 1098-102.
  50. Annunziato F., Cosmi L., Liotta F. et al. Main features of human T-helper 17 cells. Ann NY Acad Sci 2013; 1284: 66-70.
  51. Maggi L., Cimaz R., Capone M. et al. Brief report: etanercept inhibits the tumor necrosis factor a-driven shift of Th17 lymphocytes toward a nonclassic Th1 phenotype in juvenile idiopathic arthritis. Arthritis Rheumatol 2014; 66: 1372-7.
  52. Nistala K., Adams S., Cambrook H. et al. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc Natl Acad Sci USA 2010; 107: 14751-6.
  53. Bovenschen H.J., van de Kerkhof P.C., van Erp P.E. et al. Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin. J invest dermatol 2011; 9: 9-16.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Khairutdinov V.R., Belousova I.E., Samtsov A.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies