Актинический кератоз - обзор литературы

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Аннотация

Актиническому кератозу (АК) в основном подвержены пожилые люди со светлой кожей. За последние годы в связи с демографическими изменениями увеличилась распространенность АК. установленным фактором риска, приводящим к возникновению мутаций в антионкогене TP53 и онкогене H-Ras, является хроническое ультрафиолетовое воздействие (работа на открытом воздухе), которое способствует внутриэпидермальной пролиферации атипичных кератиноцитов. термин «поле канцеризации» характеризуется наличием множественного АК в участках, подверженных УФ-облучению. также АК называется преинвазивной плоскоклеточной карциномой или плоскоклеточной карциномой in situ. Риск превращения АК в плоскоклеточную карциному составляет 6-10%. Во избежание инвазивного роста рекомендуется лечение на ранних стадиях. За последние годы были разработаны различные варианты терапевтического лечения. В зависимости от степени выраженности признаков существуют методы терапии, направленные на поврежденные участки и дающие превосходные косметические и клинические результаты.

Об авторах

T. Strunk

Academic Teaching Hospital

Автор, ответственный за переписку.
Email: Strunk@klinikum-vest.de
Россия

L. Braathen

Dermatology Bern

Email: noemail@neicon.ru
Россия

R. Szeimies

Academic Teaching Hospital

Email: noemail@neicon.ru
Россия

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© Strunk T., Braathen L., Szeimies R., 2014

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