Фотостарение кожи: механизмы развития, особенности клинических проявлений

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В статье представлены современные литературные данные, касающиеся механизмов развития фотостарения кожи, вызванного ультрафиолетовым излучением УФА- и УФБ-спектров. Результатом длительного воздействия УФ-излучения являются повреждение геномной ДНК, развитие мутаций ДНК, повреждение белков, мембранных липидов, коллагеновых и эластических волокон, деградация межклеточного вещества дермы, развитие хронического воспаления, иммуносупрессия, нарушение меланогенеза и усиление ангиогенеза. Описаны основные клинические проявления фотостарения, проявляющиеся на коже, и представлена их гистологическая характеристика.

Об авторах

А. А. Кубанов

ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России

Автор, ответственный за переписку.
Email: noemail@neicon.ru
Россия

М. Б. Жилова

ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России

Email: zhilovz@cnikvi.ru
Россия

А. А. Кубанова

ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России

Email: noemail@neicon.ru
Россия

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© Кубанов А.А., Жилова М.Б., Кубанова А.А., 2014

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