Функции toll-подобных рецепторовкак компонента врожденного иммунитетаи их участие в патогенезе дерматозов различнойэтиологии



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Кожа не только выполняет функции механического барьера, защищающего организм от повреждающего воздействия различных факторов, но и участвует в иммунных реакциях, развивающихся при вторжении микроорганизмов. Toll- подобные рецепторы (TLR), опосредующие распознавание молекулярных структур патогенов, экспрессируются в коже на клетках разных типов, инициируя развитие адаптивных иммунных реакций при связывании с различными лигандами. В обзоре приведены данные о строении и функции TLR, их локализации в компартментах кожи, а также об их роли в патогенезе заболеваний кожи инфекционной этиологии и неинфекционного происхождения.

Об авторах

О Р КАТУНИНА

ФГУ «ГНЦДК Минздравсоцразвития России»

Email: katunina@cnikvi.ru
заведующая лабораторией патоморфологии, к.м.н; ФГУ «ГНЦДК Минздравсоцразвития России»

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