Email this article 
Fractional CO2 laser: a new therapeutic system forphotobiomodulation of skin remodeling and cytokineproduction in the course of tissue reparation
- Authors: Prignano F1, Campolmi P1, Bonnan P1, Ricceri F1, Cannarozzo G1, Troiano M1, Lotti T1, Prignano F2, Campolmi P2, Bonnan P2, Ricceri F2, Cannarozzo G2, Troiano M2, Lotti T2
-
Affiliations:
- Florence University
- Issue: Vol 87, No 3 (2011)
- Pages: 153-160
- Section: Articles
- URL: https://vestnikdv.ru/jour/article/view/1046
- DOI: https://doi.org/10.25208/vdv1046
- ID: 1046
Cite item
Full Text
Abstract
(SmartXide DOT, DEKA M.E.L.A., Florence, Italy) with varying energy density (2.07, 2.77 and 4.15 J/cm2). Clinical efficacy
of the said laser irradiation parameters was assessed in all of the subjects, and the skin cytokine profile was studied
by using the immunohistochemistry technique based on skin tissue samples taken prior to the treatment, right after
the treatment and in 3 and 30 days. There were significant improvements in the wrinkle and skin texture condition, and
hyperpigmentation was reduced as a result of the treatment, which proves the efficacy of using the fractional CO2 laser
for the skin photorejuvenation. The technique ensures good clinical results and is distinguished by a short rehabilitation
period and excellent safety profile. In the course of the immunohistochemistry, a relation between the skin cytokine
production, reepithelization and laser irradiation density was established.
About the authors
F Prignano
P Campolmi
P Bonnan
F Ricceri
G Cannarozzo
M Troiano
T Lotti
F Prignano
Florence University; Florence University
P Campolmi
Florence University; Florence University
P Bonnan
Florence University; Florence University
F Ricceri
Florence University; Florence University
G Cannarozzo
Florence University; Florence University
M Troiano
Florence University; Florence University
T Lotti
Florence University; Florence University
References
- Jih M.H., Kimyai-Asadi A. Fractional photothermolysis: a review and update. Semin Cutan Med Surg 2008: 27: 63-71.
- Nanni C.A., Alster T.S. Complications of carbon dioxide laser resurfacing. An evaluation of 500 patients. Dermatol Surg 1998: 24: 315-320.
- Eming S.A., Krieg T., Davidson J.M. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007: 127 (3): 514-525. Review.
- Prignano F., Domenici L., Gerlini G., Pimpinelli N., Romagnoli P. Human keratinocytes cultured without a feeder layer undergo progressive loss of differentiation markers. Histol Histopathol 1999: 14 (3): 797-803.
- Heldin C.H., Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999: 79: 1283-1316.
- Pierce G.F., Tarpley J.E., Tseng J. et al. Detection of plateletderived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds. J Clin Invest 1995: 96: 1336-1350.
- Stoscheck C.M., Nanney L.B., King L.E.Jr. Quantitative determination of EGF-R during epidermal wound healing in rats. Eur J Surg 1992: 158: 327-331.
- Johnson D.E., Williams L.T. Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 1993: 60: 1-41.
- Chen C.H., Poucher S.M., Lu J., Henry P.D. Fibroblast growth factor 2: from laboratory evidence to clinical application. Curr Vasc Pharmacol 2004: 2: 33-43.
- Ishida Y., Kondo T., Takayasu T., Iwakura Y., Mukaida N. The essential involvement of crosstalk between IFNgamma and TGF-beta in the skin wound-healing process. J Immunol 2004: 172: 1848-1855.
- Manolis E.N., Kaklamanos I.G., Spanakis N. et al. Tissue concentration of transforming growth factor b1 and basic fibroblast growth factor in skin wounds created with a CO2 laser and scalpel: a comparative experimental study, using an animal model of skin resurfacing. Wound Repair Regen 2007: 15: 252-257
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).