Research methods for molecular markers of the individual genetic risk for development ofcomplications of the urogenital chlamydia infection


The authors present the results of the first four stages of research conducted under Government Contract No.
02.740.11.0774: Development of a Technology for Molecular Diagnostics of the Individual Genetic Risk of Development of
Reproductive Function Disorders Associated with Human Urogenital Chlamydial Infection.


  1. Рудакова Е.Б., Семенченко С.И., Панова О.Ю. и др., 2004, 1. Руководство по охране репродуктивного здоровья. М: Триада-Х, 2001.
  2. Сметник В.П., Тумилович Л.Г. Неоперативная гинекология. Сметник В.П. Руководство для врачей. Книга 2. 1995; 201.
  3. Современные подходы к лечению воспалительных заболеваний женских половых органов. Метод. материалы. / Под ред. В.Н. Серова. М, 2003.
  4. Paavonen J. Immunopathogenesis of pelvic inflamantory disease and infertility - what do we know and what shal we do? J Br Fert 1996; 1: 42-45;
  5. Munday P.E. Clinical aspects of pelvic inflammatory disease. Hum Reprod 1997; Nov: 12 (11 Suppl): 121-6.
  6. Канищева Е.Ю. Воспалительные заболевания органов малого таза у женщин и их связь с инфекциями, передаваемыми половым путем. Диагностика, лечение. Вестн. дерматол. и венерол. 2002; 4: 16-23.
  7. Moss T.R., Darougar R. (2001): Human genital infections with C. trachomatis.
  8. Kamwendo F., Forslin L., Bodin L. et al. Decreasing incidences of gonorrhea- and chlamydiaassociated acute pelvic inflammatory disease: a 25-year study from an urban area of central Sweden. Sex Transmit Dis 1996; 23: 384-91.
  9. Öhman H., Triitinen A., Halttunen M., et al. IL-10 polymorphism and cell-mediated immune response to Chlamydia trachomatis. Genes and Immunity 2006; 7: 243-249.
  10. Rasouli M., Kiany S. Association of interferongamma and interleukin-4 gene polymorphisms with susceptibility to brucellosis. Cytokine 2007; 38: 49-53.
  11. Mei В., Luo Q., Du K. et al., Association of MICA gene polymorphisms with Chlamydia trachomatis infection and related tubal pathology in infertile woman. Hum Reprog 2009 Dec; 24 (12): 3090-5.
  12. Sziller I., Babula O., Ujházy A. et al. Chlamydia trachomatis infection, Fallopian tube damage and a mannose-binding lectin codon 54 gene polymorphism. Hum Reprod 2007; 22 (7): 1861-5.
  13. Moore K.W., R de Waal Malefyt R. L. Coffman and A. O'Garra. Interleukin-10 and interleukin-10 receptor. Annu Rev Immunol 2001; 19: 683- 765.
  14. Rotterberg M.E., Gigliotti-Rothfunchs A., Wigzell H. The role of IFN-gamma in the outcome of chlamydial infection. Curr Opin Immunol - 2002; 14: 444-451.
  15. Reddy B.S., Rastogi S., Das B. et al. Cytokyne expression pattern in the genital tract of Chlamydia trachomatis positive infertile women - implication of T-cell responses. Clin Exp Immunol 2004; 137: 552-558.
  16. Srivastva P., Jha R., Bas S. In in fertile women, cells from Chlamydia trachomatis infected site release higher levels of interferon-gamma, interleikin-10 and tumor necrosis factoralpha upon heat shock protein stimulation then fertile women. Biology and Endocrinology 2008; 6: 20.
  17. Beutler B., Cerami A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature. 1986; Apr 17-23; 320 (6063): 584-8.
  18. Pacheco A.G., Cardoso C.C., Moraes M.O. IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polmorphisms in association with tuberculosis susceptibility: a meta-analysis study. Hum Genet. 2008 Jun;123 (5): 477-84.
  19. Boraska V., Skrabić V., Culić V.C. et al. Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population. Biol Res. 2008; 41 (2): 157-63.
  20. Witte J.S., Palmer L.J., O'Connor R.D. et al. Relation between tumour necrosis factor polymorphism TNF- αlpha-308 and risk of asthma. Eur J Hum Genet. 2002 Jan; 10 (1): 82-5.
  21. Banno T., Gazel A., Blumenberg M. Effects of tumor necrosis factor-alpha (TNF-alpha) in epidermal keratinocytes revealed using global transcriptional profiling. J Biol Chem 2004; 279: 32633-42.
  22. Turner D.M., Williams D.M., Sankaran D. et al. An investigation of polymorphism in the interleukin- 10 gene promoter. Eur J Immunogenet 1997; 24: 1-8.
  23. Natividad A., Holland M.J., Rockett K.A. et al. Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation. Hum Mol Genet 2008; 17: 323-9.
  24. Couper K.N., Blount D.G., Riley E.M. IL-10: the master regulator of immunity to infection. J Immunol 2008; 180: 5771-7.
  25. Bierie B., Moses H.L. Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine Growth Factor Rev 2010 Feb; 21 (1): 49-59. Epub 2009 Dec 16.

Copyright (c) 2011 Plakhova K.I., Volkov I.A., Khayrullin R.F., Rotanov S.V., Popov D.V., Rakhmatulina M.R., Frigo N.V., PLAKHOVA K.I., VOLKOV I.A., KHAIRULIN R.F., ROTANOV S.V., POPOV D.V., RAKHMATULLINA M.R., FRIGO N.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies