Vol 87, No 6 (2011)

The authors discuss problems of selection of an adequate therapy for treatment of patients suffering from acne taking into account the clinical picture, course of the pathological process, efficiency of previous treatment, presence or absence of endocrinopathies.

The IL12B gene encodes protein р40 being a common subunit of interleukin-12 and interleukin-23 playing an important part in the pathogenesis of psoriasis. The IL12B gene has polymorphism rs12188300, which can be associated with the risk of psoriasis development. The goal of the study was to assess the distribution of alleles of polymorphism rs12188300 in psoriatic patients in the Northwestern region of Russia. Genotyping was carried out using the real-time allele-specific polymerase chain reaction. An increased occurrence of a rare allele T in psoriatic patients as compared to healthy people was observed (OR = 1.96, р = 0.0007). The occurrence of the rare allele T in patients with psoriatic arthritis was higher than in the control group (OR = 3.49, р = 0.005). These results suggest that rs12188300 polymorphism of the IL12B gene is a new genetic marker of psoriasis and psoriatic arthritis.

полиморфизмы, хламидийная инфекция, цитокины. The authors provide a detailed clinical and laboratory description of female patients with the Chlamydia infection of the lower urogenital tract and small pelvis organs as well as patients with secondary infertility (Chlamydia infection in the anamnesis). The authors also present the results of a pilot study aimed at determining the content of cellular metabolism mediators (cytokines IL-2, IL-4, IL-6, IL-8, IL-10 and IFN-alpha) in blood and cervical secret samples as well as a study of single-nucleotide polymorphisms of cytokine encoding genes.

The authors conducted a comparative study of the diagnostic value (sensitivity, specificity, efficiency and predictive value of positive and negative results) of immunology methods (microprecipitation test, RPR, complement-fixation test, immunofluorescence test with whole spinal fluid, ELISA, passive hemagglutination test, Treponema pallidum immobilization test, immunoblotting) for studying the cerebrospinal fluid in 37 neurosyphilitic patients and 31 patients with syphilis in the anamnesis but without any clinical and laboratory data confirming the syphilitic affection of the nervous system. The highest diagnostic efficiency indices for neurosyphilis were noted for such methods as microprecipitation test (80.9%), passive hemagglutination test (98.5%) and immunoblotting (97.0%), which enables the authors to recommend the methods as standard neurosyphilis diagnostics methods in the territory of the Russian Federation. It was revealed that antibodies for pale treponema antigens Tr17 and Tr47 were detected in the course of immunoblotting most often regardless of any clinical manifestations and duration of the syphilitic infection. The authors set the priorities for individual examination methods when diagnosing asymptomatic, early and late meningovascular neurosyphilis. They also developed a diagnostic algorithm for detecting neurosyphilis based on the sequential application of ELISA/immunoblotting, microprecipitation test and passive hemagglutination test.

The authors present the results of a study of efficiency of Skin-Cap in treatment of withdrawal dermatitis after application of topical glucocorticosteroids. The study involved 46 patients who had topical corticosteroids applied on their face skin in the anamnesis, who were divided into two groups depending on the therapy. The efficiency of treatment was assessed based on the dynamics of the Dermatological Index of Symptom Scale (DISS). A comparative assessment of the efficiency of treatment with the use of the Skin-Cup cream and non-specific antiinflammatory drugs showed the highest efficiency of application of activated zinc pyrithione, which was became apparent in reliably more intensive reduction of the DISS and certain subjective and objective symptoms of the inflammatory reaction. Good results of the study substantiate the expediency of administration of Skin-Cap in treatment of patients with symptoms of withdrawal dermatitis as this drug facilitates the course of the disease and results in faster elimination of the inflammation. Application of the cream containing activated zinc pyrithione makes it possible to avoid administration of system drugs.

Powered by monitoring a patient with clinical manifestations of erythema associated with nekroliticheskoyglyukagonomoy. The attention to the diagnostic criteria of the disease. Formation of cutaneous syndrome glyukagonomelets talk about its nosological specificity.

A new technology of production of oral isotretinoin, LIDOSE®, made it possible to increase its bioavailability by 20%, preserve high efficiency of the drug while reducing the quantity of isotretinoin to be taken orally by 20%, and, therefore, reduce both daily and course dose of the drug. The authors present the results of a study of clinical efficiency of Acnecutan in treatment of patients suffering from medium to severe acne taking into account side effects. They also give data on the administration of Acnecutan, which demonstrates the highest efficiency in treatment of this disease.

The authors present the results of a prospective, open-label, post-registration comparative study of the monotherapy of mild to moderate acne with an inflammatory component. 30 subjects aged 15-35 were engaged in the study. Subjects from Group 1 (n = 15) received Clindovit® in the form of 1% gel, and subjects from Group 2 (n = 15) received a combination of erythromycin and zinc in the form of lotion. The duration of treatment and participation in the study was 8 weeks. Dynamics of clinical manifestations of the disease, Dermatology Life Quality Index (DLQI), Psychological and Social Effects of Acne (APSEA), frequency and severity of adverse events against the background of treatment were assessed. The results of the study enabled the investigators to make a conclusion about efficacy, safety and good tolerance of Clindovit® gel as a monotherapy of mild to moderate acne with an inflammatory component.

The authors describe clinical results of the laser liposuction procedure using the MultiPlex technology. They give a comparative quantitative assessment of the effect of laser and tumenescent liposuction on skin retraction and turgor by the example of three patients. Processing local fat deposits by laser emission resulted in the increased skin turgor and elasticity in the liposuction area in all subjects, and skin retraction and higher skin elasticity were more evident than with the use of the traditional liposuction method.

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