Association of polymorphism of IL12B gene and predisposition to psoriasis among the populationof the Northwestern region of Russia



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Abstract

The IL12B gene encodes protein р40 being a common subunit of interleukin-12 and interleukin-23 playing an important
part in the pathogenesis of psoriasis. The IL12B gene has polymorphism rs12188300, which can be associated with the
risk of psoriasis development. The goal of the study was to assess the distribution of alleles of polymorphism rs12188300
in psoriatic patients in the Northwestern region of Russia. Genotyping was carried out using the real-time allele-specific
polymerase chain reaction. An increased occurrence of a rare allele T in psoriatic patients as compared to healthy people
was observed (OR = 1.96, р = 0.0007). The occurrence of the rare allele T in patients with psoriatic arthritis was higher
than in the control group (OR = 3.49, р = 0.005). These results suggest that rs12188300 polymorphism of the IL12B gene
is a new genetic marker of psoriasis and psoriatic arthritis.

References

  1. Баранов В.С., Глотов О.С., Баранова Е.В. Геномика старения и предиктивная медицина. Успехи геронтологии, 2010; 23 (3): 329-338.
  2. Wang W.Y., Barratt B.J., Clayton D.G. et al. Genome-wide association studies: theoretical and practical concerns. Nature Reviews Genetics 2005; 6 (2): 109-118.
  3. Ellinghaus E., Ellinghaus D., Stuart P.E. et al. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nature Genetics 2010; 42 (11): 991-995.
  4. Duffin K.С., Krueger G.G. Genetic variations in cytokines and cytokine receptors associated with psoriasis found by genome-wide association. J Invest Dermatol 2009; 129: 827-833.
  5. Huffmeier U., Uebe S., Ekici A.B. et al. Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nature Genetics 2010; 42 (11): 996-999.
  6. Strange A., Capon F., Spencer C.C. et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nature Genetics 2010; 42 (11): 985-990.
  7. Nestle F.O., Kaplan D.H., Barker J. Review article: Mechanisms of Disease. Psoriasis. N Engl J Med 2009; 361: 496-509.
  8. Lee E., Trepicchio W.L., Oestreicher J.L. et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 2004; 199 (1): 125-130.
  9. Krueger G.G., Langley R.G., Leonardi C. et al. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 2007; 356: 580-592.
  10. Nair R.P., Ruether A., Stuart P.E. et al. Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 2008; 128 (7): 1653-1661.
  11. Интернет-ресурс Национального центра биотехнологической информации. http://www. ncbi.nlm.nih.gov/SNP/.
  12. Elder J.T. Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. Genes and Immunity 2009; 10 (3): 201-209.
  13. Moll J.M., Wright V. Psoriatic arthritis. Seminars in Arthritis and Rheumatism 1973; 3 (1): 55-78.

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Copyright (c) 2011 Khayrutdinov V.R., Mikhaylichenko A.F., Piskunova A.A., Samtsov A.V., Ivanov A.M., Imyanitov E.N., KHAIRUTDINOV V.R., MIKHAILICHENKO A.F., PISKUNOVA A.A., SAMTSOV A.V., IVANOV A.M., IMYANITOV Y.N.

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