Association of polymorphism of IL12B gene and predisposition to psoriasis among the populationof the Northwestern region of Russia

Abstract

The IL12B gene encodes protein р40 being a common subunit of interleukin-12 and interleukin-23 playing an important
part in the pathogenesis of psoriasis. The IL12B gene has polymorphism rs12188300, which can be associated with the
risk of psoriasis development. The goal of the study was to assess the distribution of alleles of polymorphism rs12188300
in psoriatic patients in the Northwestern region of Russia. Genotyping was carried out using the real-time allele-specific
polymerase chain reaction. An increased occurrence of a rare allele T in psoriatic patients as compared to healthy people
was observed (OR = 1.96, р = 0.0007). The occurrence of the rare allele T in patients with psoriatic arthritis was higher
than in the control group (OR = 3.49, р = 0.005). These results suggest that rs12188300 polymorphism of the IL12B gene
is a new genetic marker of psoriasis and psoriatic arthritis.

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Copyright (c) 2011 Khayrutdinov V.R., Mikhaylichenko A.F., Piskunova A.A., Samtsov A.V., Ivanov A.M., Imyanitov E.N., KHAIRUTDINOV V.R., MIKHAILICHENKO A.F., PISKUNOVA A.A., SAMTSOV A.V., IVANOV A.M., IMYANITOV Y.N.

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