Urogenital chlamydia infection in women: patient management tactics according to present-day foreign and Russian recommendations

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The article present data on current approaches to laboratory diagnostics and treatment of urogenital chlamydia infection in women. According to Russian and foreign guidelines, azithromycin, josamycin and doxycycline monohydrate belong to the most efficient antimicrobial drugs for the treatment of urogenital chlamydia infection in non-pregnant women. As for the treatment of pregnant patients suffering from this pathology, azithromycin and josamycin are the most optimal drugs in terms of safety and treatment efficacy according to both Russian and foreign guidelines.

About the authors

A. A. Khryanin

Novosibirsk State Medical University

Author for correspondence.
Email: khryanin@mail.ru
Россия

References

  1. Land J.A., Van Bergen J.E.A.M., Morre S.A., Postma M.J. Epidemiology of Chlamydia trachomatis infection in women and the costeffectiveness of screening. Human Reproduction Update 2010; 16 (2): 189-204
  2. WHO. Prevention and control of sexually transmitted infections: draft global strategy, 2006. Available from: http://www.who.int/reproductive-health/docs/stis_strategy.pdf.
  3. No authors listed. CDC Grand Rounds: Chlamydia. MMWR Morb Mortal Wkly Rep. 2011; 60 (12): 370-3.
  4. Peipert J.F. Genital chlamydial infections. N Engl J Med 2003; 349: 2424-2430.
  5. US Preventive Services Task Force. Screening for chlamydial infection: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2007; 147: 128-34.
  6. Lanjouw E., Ossewaarde J.M., Stary A. et al. 2010 European guideline for the management of Chlamydia trachomatis infections. Int J STD AIDS. 2010; 21 (11): 729-37.
  7. Wilson J.S., Honey E., Templeton A. et al., for the EU Biomed Concerted Action Group. A systematic review of the prevalence of Chlamydia trachomatis among European women. Hum Reprod Update 2002; 28: 385-394.
  8. Van Bergen J.E.A.M., De Feijter E.M., Gotz H.M., CSI Netherlands 2007-2010: A Large Scale Internet Based Chlamydia Screening Implementation Programme. Seattle, USA: Abstractbook 17th ISSTDR, 2007.
  9. Van de Laar M.J., Morré S.A. Chlamydia: a major challenge for public health. Euro Surveill. 2007 Oct 1; 12 (10): E1-2.
  10. Российское общество дерматовенерологов. Инфекции, передаваемые половым путем. Клинические рекомендации. Дерматовенерология. Под ред. А.А. Кубановой. М.: ДЭКС-ПРЕСС 2010; 413-425
  11. Sutton M., Sternberg M., Zaidi A., et al. Trends in pelvic inflammatory disease hospital discharges and ambulatory visits, United States, 1985-2001. Sex Transm Dis 2005; 32: 778-84.
  12. Haggerty C., Gottlieb S., Taylor B., et al. Risk of sequelae after Chlamydia trachomatis genital infection in women. J Infect Dis 2010; 201 (Suppl 2): S134-55.
  13. Oakeshott P., Kerry S., Aghaizu A. et al. Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial. BMJ 2010; 340: 16-42.
  14. Macaluso M., Wright-Schnapp T.J., Chandra A. et al. A public health focus on infertility prevention, detection, and management. Fertil Steril 2010; 93: 16.e1-10.
  15. Feinberg E.C., Larsen F.W., Catherino W.H., Zhang J., Armstrong A.Y. Comparison of assisted reproductive technology utilization and outcomes between Caucasian and African American patients in an equal-access-to-care setting. Fertil Steril 2006; 85: 888-94.
  16. Kovacs L., Nagy E., Berbik I., et al. The frequency and the role of Chlamydia trachomatis infection in premature labor. Int. J. Gynaecol. Obstet. 1998. 62: 47-54.
  17. Chen M.Y., Fairley C.K., De Guingand D., et al. Screening pregnant women for chlamydia: what are the predictors of infection? Sex Transm Infect. 2009 Feb; 85 (1): 31-5. Epub 2008 Aug 15.
  18. Евсюкова Н.Н., Кошелева Н.Г., Башлякова М.М. Хламидийная инфекция в акушерстве и перинатологии. СПб., 1995
  19. STDs & Pregnancy - CDC Fact Sheet. Available from: http://www.cdc.gov/std/pregnancy/STDFact-Pregnancy.htm.
  20. Rastogi S., Kapur S., Salhan S. et al. Chlamydia trachomatis infection in pregnancy: Risk factor for an adverce outcome. Brit J Biomed Scien 1999; 56: 94-98.
  21. Andrews W.W., Goldenberg R.L., Mercer B. et al. The Preterm Prediction Study: association of second-trimester genitourinary Chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol 2000; 183: 662-668.
  22. Cohen I., Veille J.C., Calkins B.M. Improved pregnancy outcome following successful treatment of chlamydial infection. JAMA. 1990; 263: 3160- 3163.
  23. Mullick S., Watson-Jones D., Beksinska M. et al. Sexually transmitted infections in pregnancy: prevalence, impact on pregnancy outcomes, and approach to treatment in developing countries. Sex. Trans. Infect. 2005; 81: 294-302.
  24. Baud D., Regan L., Greub G. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Curr Opin Infect Dis 2008; 21: 70-76.
  25. Van de Laar M.J., Fontaine J. ECDC guidance on chlamydia control in Europe: next steps. Euro Sur-veill 2009 Jul 2; 14 (26). pii: 19260.
  26. Fiest A., Sydler Т., Gebbers S.S. et al. No association of Chlamydia with abortion. J Soc Med 1999. 92 (5): 237-238.
  27. Miller J.M., Martin D.H. Treatment of Chlamydia trachomatis infections in pregnant women. Drugs. 2000; 60 (3): 597-605.
  28. Протокол ведения больных «Инфекции, передаваемые половым путем». «Урогенитальная хламидийная инфекция». Под ред. В.И. Кисиной, M.: Ньюдиамед 2011; С. 164-191
  29. Workowski K.A., Berman S.; Centers for Disease Control and Prevention (CDC). Sexually Transmitted Diseases Treatment Guidelines, 2010. MMWR Recomm Rep 2010; 59 (RR-12): 1-10
  30. Watson E.J., Templeton A., Russell I. et al. The accuracy and efficacy of screening tests for Chlamydia trachomatis: a systematic review. J Med Microbiol 2002; 51: 1021-1031.
  31. Lau C.Y., Qureshi A.K. Azithromycin versus doxycycline for genital chlamydial infections: a metaanalysis of randomized clinical trials. Sex Transm Dis 2002; 29 (9): 497-502.
  32. Adimora A.A. Treatment of uncomplicated genital Chlamydia trachomatis infections in adults. Clin Infect Dis 2002; 35: 183-186.
  33. Schillinger J.A., Kissinger P., Calvet H., et al. Patient-delivered partner treatment with azithromycin to prevent repeated Chlamydia trachomatis infection among women: a randomized, controlled trial. Sex Transm Dis 2003; 30: 49-56.
  34. Golden M.R., Whittington W.L., Handsfield H.H., et al. Effect of expedited treatment of sex partners on recurrent or persistent gonorrhea or chlamydial infection. N Engl J Med 2005; 352: 676-85.
  35. Клинические рекомендации. Акушерство и гинекология. Под ред. Г.М. Савельевой, В.Н. Серова, Г.Т. Сухих. 3-е изд., испр. и доп. M.: ГЭОТАР-Медиа 2009; (880): 703-710
  36. Рациональная фармакотерапия в акушерстве, гинекологии и неонатологии. Под ред. В.Н. Серова, Г.Т. Сухих. M.: Литтерра 2010
  37. Lucisano A., Vitale A.M., Cinque B., Morandotti M.G., Leone F., Sanna A., Dell'Acqua S. Josamycin in the treatment of chlamydial genital infections in infertile women. J Chemother 1989 Jul; 1 (4 Suppl): 906-8
  38. Primiero F.M., Caruso G., Grottanelli F., Chiarini F., De Stasio A., Guarino M., Martini A. Josamycin in the treatment of Chlamydia trachomatis cervicitis. J Chemother 1989 Jul; 1 (4 Suppl): 909-10.
  39. Fedele L., Acaia B., Marchini M., Grassi R., Benzi-Cipelli R., Bonino S. Treatment of Chlamydia trachomatis endometritis with josamycin. J Chemother 1989 Jul; 1 (4 Suppl): 911-2.
  40. De Punzio C., Neri E., Metelli P., Bianchi M.S., Campa M., Fioretti P. Epidemiology and therapy of Chlamydia trachomatis genital infection in women. J Chemother 1992 Jun; 4 (3): 163-6.
  41. Colombo U., Pifarotti G., Amidani M., Viezzoli T., Pifarotti P. Rokitamycin in the treatment of female genital Chlamydia and Mycoplasma infections. Comparative study vs josamycin. Minerva Ginecol 1998 Nov; 50 (11): 491-7.
  42. Потекаев Н.С. Джозамицин (вильпрафен) в терапии урогенитального хламидиоза. Вестн. дерматол. венерол. 2000; (1): 48-50
  43. Минкевич К.В., Зайцев А.А. Применение макролида нового поколения вильпрафена для лечения генитального хламидиоза у женщин. Акушерство и гинекология 2001; (8): 14-18
  44. Малова И.О. Вильпрафен в лечении смешанной хламидийно-микоплазменной инфекции урогенитального тракта у женщин репродуктивного возраста. Вестн. дерматол. венерол. 2004; (3): 69-72
  45. Васильев М.М., Наволоцкая Т.И., Смирнова А.А., Фриго Н.В., Ротанов С.В., Сидорович С.Ю. Применение джозамицина (вильпрафена) у женщин с хламидийной инфекцией нижних и верхних отделов мочеполового тракта. Вестн. дерматол. венерол. 2005; (3): 78-80
  46. Киянская Е.С., Савицкая И.Л., Хамандяк Ю.В. и соавт. Опыт применения джозамицина (Вильпрафена) в лечении хламидийных и смешанных инфекций урогенитального тракта. Тезисы 2 Форума Медицины и Красоты НАДК. М., 2009
  47. Кузнецов А.В., Соколов Г.Н., Соколовский Е.В. К вопросу о применении вильпрафена в лечении урогенитального хламидиоза. Aavilablle from: http://www.medicus.ru/?cont=article&art_id=413
  48. Söltz-Szöts J., Schneider S., Niebauer B. et al. Significance of the dose of josamycin in the treatment of chlamydia infected pregnant patients. Z Hautkr. 1989; 64 (2): 129-31.
  49. Simunic V., Vrcic H., Culig J., et al. Single dose of azithromycin in the treatment of sexually transmitted disease in infertile and pregnant women. In: The 3rd International Conference on the Macrolides, Azalides and Streptogramins. Lisbon, 1996: abstr. 2.21.
  50. Rahangdale L., Guerry S., Bauer H.M. et al. An observational cohort study of Chlamydia trachomatis treatment in pregnancy. Sex Transm Dis 2006; 33: 106-110.
  51. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines 2006. MMWR 2006; 55 (№ RR-11).
  52. Kacmar J., Cheh E., Montagno A., Peipert J.F. A randomized trial of azithromycin versus amoxicillin for the treatment of Chlamydia trachomatis in pregnancy. Infect Dis Obstet Gynecol 2001; 9: 197-202.
  53. Jacobson G.F., Autry A.M., Kirby R.S., et al. A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy. Am J Obstet Gynecol 2001; 184: 1352-1354.
  54. Wehbeh H.A., Ruggeirio R.M., Shahem S. et al. Single-dose azithromycin for Chlamydia in pregnant women. J Reprod Med 1998; 43: 509-514.
  55. Adair C.D., Gunter M., Stovall T.G. et al. Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin. Obstet. Gynecol. 1998; 91: 165-168.
  56. Edwards M.S., Newman R.B., Carter S.G. et al. Randomized clinical trial of azithromycin vs erythromycin for the treatment of Chlamydia cervicitis in pregnancy. Infect Dis Obstet Gynecol 1997; 4: 333-337.
  57. Rosenn M.F., Macones G.A., Silverman N.S. Randomized trial of erythromycin and azithromycin for treatment of chlamydial infection in pregnancy. Infect Dis Obstet Gynecol 1996; 3: 241-244.
  58. Gunter M.E., Adair C.D., Ernest J.M., McElroy G. Azithromycin powder versus erythromycin in the treatment of chlamydial cervicitis in pregnancy. Infect. Dis. Obstet. Gynecol. 1996; 4: 53.
  59. Bush M.R., Rosa C. Azithromycin and erythromycin in the treatment of cervical chlamydial infection during pregnancy. Obstet. Gynecol. 1994; 84: 61-63.
  60. Pitsouni E., Iavazzo C., Athanasiou S., Falagas M.E. Single-dose azithromycin versus erythromycin or amoxicillin for Chlamydia trachomatis infection during pregnancy: a meta-analysis of randomised controlled trials. Int. J Antimicrob Agents 2007; 30 (3): 213-221.
  61. Brocklehurst P., Rooney G. Interventions for treating genital chlamydia trachomatis infection in pregnancy (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd.
  62. Centers for Disease Control and Prevention. Guidelines for treatment of sexually transmitted diseases. MMWR. 2002; 51 (6): 34.
  63. Alary M., Loey J.R., Moutquih J.M. et al. Randomized prospective study comparing erythromycin and amoxycillin in the treatment of genital chlamydial infection in pregnancy. Lancet 1994; 344: 1461-1465.
  64. Magat A.H., Alger L.S., Nagey D.A. et al. Doubleblinded randomized study comparing amoxicillin and erythromycin for treatment of Chlamydia trachomatis in pregnancy. Obstet Gynecol 1993; 81: 745-749.
  65. Kallen B.A.J., Otterblad Olausson P., Danielsson B.R. Is erythromycin therapy teratogenic in humans? Reprod Toxicol 2005, 20, 209-14.
  66. Кисина В.И. Отечественная и международная практика лечения хламидийной инфекции у беременных с позиции доказательной медицины. Гинекология 2010; (4): 8-13
  67. Miller Jr. J.M. Efficacy and tolerance of single-dose azithromycin for treatment of chlamydial cervicitis during pregnancy. Infect. Dis Obstet Gynecol 1995; 3: 189-192
  68. Stary A. European Branch of the International Union against Sexually Transmitted Infection and the European Office of the World Health Organization. European guideline for the management of chlamydial infection. Int J STD AIDS. 2001; 12 Suppl 3: 30-3
  69. Справочник Видаль «Лекарственные препараты в России» 2011г. Вильпрафен. http://www.vidal.ru/poisk_preparatov/wilprafen.htm
  70. Czeizel A.E., Rockenbauer M., Olsen J., Sоrensen H.T. A case-control teratological study of spiramycin, roxithromycin, oleandomycin and josamycin. Acta Obstet Gynecol Scand 2000; 79 (3): 234-7
  71. Юцковский А.Д., Юцковская Я.А., Ивашков Е.А. К проблеме урогенитальных инфекций у беременных: опыт лечения вильпрафеном. Росс. журн. кож. вен. бол. 2002; (6): 67-70
  72. Берлев И.В., Тестова Г.В. Лечение урогенитального хламидиоза у беременных. Инфекции в хирургии 2003; (1): 4
  73. Fedele L., Acaia B., Marchini M. et al. Treatment of Chlamydia trachomatis endometritis with josamycin. J Chemother 1989; 1 (4 Suppl): 911-2.
  74. Khrianin A.A., Reshetnikov O.V. Is it safe to use josamycin in the obstetrics practice in Russia? Antibiot Khimioter. 2007; 52 (7-8): 32-6.
  75. Charles P., Stumpf P., Buffet P., et al. Two unusual glandular presentations of tick-borne tularemia. Med Mal Infect 2008; 8 (3): 159-61.
  76. See H., Lachenaud J., Alberti C., et al. Outcome of very preterm infants with Mycoplasma/Ureaplasma airway colonization treated with josamycine. Acta Paediatr 2010; 99 (4): 625-6.
  77. Хрянин А.А., Решетников О.В. Макролиды в лечении хламидийной инфекции у беременных (эффективность, безопасность, экономичность). Рус. мед. журн. 2008; 16 (1): 23-27. http://www.rmj.ru/articles_5770.htm
  78. Dylewski J., Clecner B., Dubois J., et al. Comparison of spiramycin and doxycycline for treatment of Chlamydia trachomatis genital infections. Antimicrob. Agents Chemother. 1993; 37 (6): 1373-1374
  79. Савичева А.М., Башмакова М.А. Урогенитальный хламидиоз у женщин и его последствия. М.: Медицинская книга 1998; 65-87
  80. Глазкова Л.К., Герасимова Н.М. Терешина Л.П. Опыт клинического применения ровамицина в терапии беременных с урогенитальной хламидийной инфекцией. Вестн. дерматол. венерол. 1997; (5): 75-76
  81. Качалина Т.С., Каткова Н.Ю. Выбор препарата для антибактериальной терапии хламидийной, микоплазменной и уреаплазменной инфекций у беременных. Вестн. Рос. ассоц. дерматовенерол. 2001; (2): 76-80

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