Prospects of the practical use of nanoparticles in dermatology

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The review presents data from foreign literature sources on the problem of using nanoparticles for theranostics of skin diseases. The article examines properties and operating principles of nanomaterials used most frequently for drug encapsulation and emphasizes advantages of such systems for the treatment of different dermatoses. The need in further exploration of this subject due to underinvestigated adverse events caused by nanoparticles is discussed.

About the authors

A. A. Kubanova

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Russian Federation

S. R. Utz

Saratov State Medical University named after V.I. Rasumovsky

Russian Federation

A. A. Kubanov

State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation

Russian Federation

M. A. Persati

Saratov State Medical University named after V.I. Rasumovsky

Russian Federation

YU. I. Svenskaya

National research Saratov State University named after N.G. Chernyshevsky

Russian Federation


  1. Papakostas D., Rancan F., Sterry W., Blume-Peytavi U., Vogt A. Nanoparticles in dermatology. Archives of Dermatological Research 2011; 303: 533-550.
  2. Silva E.L., Carneiro G., De Araujo L.A., et al. Solid Lipid Nanoparticles Loaded with Retinoic Acid and Lauric Acid as an Alternative for Topical Treatment of Acne Vulgaris. Journal of Nanoscience and Nanotechnology 2015; 15 (1): 792-799.
  3. Fang C.L., Aljuffali I.A., Li Y.C., Fang J.Y. Delivery and targeting of nanoparticles into hair follicles. Therapeutic delivery 2014; 5 (9): 991-1006.
  4. Patzelt A., Lademann J. Drug delivery to hair follicles. Expert Opinion on Drug Delivery 2013; 10 (6): 787-797.
  5. Boixeda P, Feltes F, Santiago J., Paoli J. Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies. Actas Dermo-Sifiliograficas 2015; 106 (3): 168-179.
  6. Тараховский Ю.С. Интеллектуальные липидные наноконтейнеры в адресной доставке лекарственных веществ. М: ЛКИ; 2011.
  7. Prow T.W., Grice J.E., Lin L.L., Faye R., Butler M., Becker W., Wurm E.M., Yoong C., Robertson T.A., Soyer H.P., Roberts M.S. Nanoparticles and microparticles for skin drug delivery. Advanced Drug Delivery Reviews 2011; 63 (6): 470-491.
  8. Gupta M., Agrawal U., Vyas S.P. Nanocarrier-based topical drug delivery for the treatment of skin diseases. Expert Opinion on Drug Delivery 2012; 9: 783-804.
  9. Pinto M.F., Moura C.C., Nunes C., Segundo M.A., Lima S.A., Reis S. New topical formulation for psoriasis: Development of methotrexate-loaded nanostructured lipid carriers. International Journal of Pharmaceutics 2014; 477 (1-2): 519-526.
  10. Panyam J., Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Advanced Drug Delivery Reviews 2012; 64: 61-71.
  11. Ghanbarzadeh S., Hariri R., Kouhsoltani M., Shokri J., Javadzadeh Y., Hamishehkar H. Enhanced stability and dermal delivery of hydroquinone using solid lipid nanoparticles. Colloids and Surfaces B Biointerfaces 2015; 136: 1004-1010.
  12. Radhakrishnan K., Raichur A.M. Biologically triggered exploding protein based microcapsules for drug delivery. Chemical communications 2012; 48 (17): 2307-2309.
  13. DeLouise L.A. Applications of nanotechnology in dermatology. Journal of Investigative Dermatology 2012; 132 (3): 964-975.
  14. Labouta H.I., Schneider M. Interaction of inorganic nanoparticles with the skin barrier: current status and critical review. Nanomedicine 2013; 9 (1): 39-54.
  15. Sheikh S., Ateeq A., Shoukath M.A., Moghis U.A., Mahesh P., Saptarshi D., Kale P., Maheshwari K., Barkate H.V., Pathak H.L., Mushtaq M., Ahmad I.A. New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia. Journal of Clinical & Experimental Dermatology Research 2015; 6 (1): 253.
  16. Arif T., Nisa N., Amin S.S., Shoib S., Mushtaq R., et al. Therapeutic and Diagnostic Applications of Nanotechnology in Dermatology and Cosmetics. Journal of Nanomedicine & Biotherapeutic Discovery 2015; 5: 134.
  17. Королева м.Ю., Юртов Е.В. Наноэмульсии: свойства, методы получения и перспективные области применения. Успехи химии 2012; 81 (1): 21-43.
  18. Wu Y., Li Y.H., Gao X.H., Chen H.D. The application of nanoemulsion in dermatology: An overview. Journal of Drug Targeting 2013; 21: 321-327.
  19. Alnasif N., Zoschke C., Fleige E., Brodwolf R., Boreham A., Rühl E., Eckl K.M., Merk H.F., Hennies H.C., Alexiev U., Haag R., Küchler S., Schäfer-Korting M. Penetration of normal, damaged and diseased skin - an in vitro study on dendritic core-multishell nanotransporters. Journal of Controlled Release 2014; 185: 45-50.
  20. Collins A., Nasir A. Nanotechnology and dermatology: Benefits and pitfalls. Giornale Italiano di Dermatologia e Venereologia 2011; 146: 115-126.
  21. Zhang Y., Chan H.F., Leong K.W. Advanced materials and processing for drug delivery: the past and the future. Advanced drug delivery reviews 2013; 65 (1): 104-120.
  22. Dexter R., Benoff B. PH-sensitive microcapsules. EP Patent 0,823,993. 2002.
  23. Poh S., Lin J.B., Panitch A. Release of Antiinflammatory Peptides from Thermosensitive Nanoparticles with Degradable Cross-Links Suppresses Pro-inflammatory Cytokine Production. Biomacromolecules 2015; 16 (4): 1191-1200.
  24. Anandhakumar S. et al. Silver nanoparticle synthesis: novel route for laser triggering of polyelectrolyte capsules. ACS applied materials & interfaces 2011; 3 (9): 3419-3424.
  25. Arora S., Tyagi N., Bhardwaj A., Rusu L., Palanki R., Vig K., Singh S.R., Singh A.P., Palanki S., Miller M.E., Carter J.E., Singh S. Silver nanoparticles protect human keratinocytes against UVB radiation-induced DNA damage and apoptosis: potential for prevention of skin carcinogenesis. Nanomedicine 2015; 11 (5): 1265-1275.
  26. Li J., Wang Y., Liang R., An X., Wang K., Shen G., Tu Y., Zhu J., Tao J. Recent advances in targeted nanoparticles drug delivery to melanoma. Nanomedicine 2015; 11 (3): 769-794.
  27. Wicki A., Witzigmann D., Balasubramanian V., Huwyler J. Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. Journal of Controlled Release 2015; 200: 138-157.
  28. Rastogi V., Yadav P., Bhattacharya S.S., Mishra A.K., Verma N., Verma A. et al. Carbon nanotubes: An emerging drug carrier for targeting cancer cells. Journal of Drug Delivery 2014; 670815.
  29. Mundra R.V., Wu X., Sauer J., Dordick J.S., Kane R.S. Nanotubes in biological applications. Current Opinion in Biotechnology 2013; 28C: 25-32.
  30. Liu T.-Y. et al. A novel ultrasound-triggered drug vehicle with multimodal imaging functionality. Acta biomaterialia 2013; 9 (3): 5453-5463.
  31. Giustetto P. et al. Release of a paramagnetic magnetic resonance imaging agent from liposomes triggered by low intensity non-focused ultrasound. Journal of Medical Imaging and Health Informatics 2013; 3 (3): 356-366.
  32. Paszko E. et al. Nanodrug applications in photodynamic therapy. Photodiagnosis and photodynamic therapy 2011; 8 (1): 14-29.
  33. Qian J. et al. Photosensitizer encapsulated organically modified silica nanoparticles for direct two-photon photodynamic therapy and in vivo functional imaging. Biomaterials 2012; 33 (19): 4851-4860.
  34. Eshghi H. et al. Protoporphyrin IX-gold nanoparticle conjugates as an efficient photosensitizer in cervical cancer therapy. Photodiagnosis and Photodynamic Therapy 2013; 10 (3): 304-312.
  35. Khlebtsov B. et al. Nanocomposites containing silica-coated gold-silver nanocages and Yb-2,4-dimethoxyhematoporphyrin: multifunctional capability of IR-luminescence detection, photosensitization, and photothermolysis. ACS nano 2011; 5 (9): 7077-7089.
  36. Nyokong T., Antunes E. Influence of nanoparticle materials on the photophysical behavior of phthalocyanines. Coordination Chemistry Reviews 2013; 257 (15-16): 2401-2418.
  37. Colombeau L., Acherar S., Baros F., Arnoux P., Gazzali A.M., Zaghdoudi K., Toussaint M., Vanderesse R., Frochot C. Inorganic Nanoparticles for Photodynamic Therapy. Topics in Current Chemistry 2016; 370: 113-134.
  38. Li J., Zhuang Z., Jiang B., Zhao P., Lin C. Advances and perspectives in nanoprobes for noninvasive lymph node mapping. Nanomedicine 2015; 10 (6): 1019-1036.
  39. Si C., Zhang Y., Lv X., Yang W., Ran Z., Sun P. In vivo lymph node mapping by Cadmium Tellurium quantum dots in rats. Journal of Surgical Research 2014; 192 (2): 305-311.
  40. Vogt A., Rancan F., Ahlberg S., Nazemi B., Choe C.S., Darvin M.E., Hadam S., Blume-Pey-tavi U., Loza K., Diendorf J., Epple M., Graf C., Rühl E., Meinke M.C., Lademann J. Interaction of dermatologically relevant nanoparticles with skin cells and skin. Beilstein Journal of Nanotechnology 2014; 5: 2363-2373.
  41. Couvreur P. Nanoparticles in drug delivery: past, present and future. Advanced Drug Delivery Reviews 2013; 65 (1): 21-23.
  42. Keck C., Müller R. Nanotoxicological classification system (NCS)-A guide for the risk-benefit assessment of nanoparticulate drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics 2013; 84: 445-448.
  43. Larese Filon F., Mauro M., Adami G., Bovenzi M., Crosera M. Nanoparticles skin absorption: New aspects for a safety profile evaluation. Regulatory Toxicology and Pharmacology 2015; 72 (2): 310-322.

Copyright (c) 2016 Kubanova A.A., Utz S.R., Kubanov A.A., Persati M.A., Svenskaya Y.I.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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