A case of localized bullous scleroderma

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Abstract

Bullous scleroderma is a rare type of the focal form of the disease mainly affecting the skin and characterized by induration and sclerosis foci as well as subepidermal blisters containing a transparent matter. The article describes a case study of bullous scleroderma in an adult woman with localized skin eruptions in the area of the left breast, which were completely regressed after a standard therapy with the use of drugs having an effect on collagen synthesis.

About the authors

A. L. Bakulev

State budget educational institution of higher professional education “Saratov State Medical University named after V.I. Razumovsky” of Ministry of Health of the Russian Federation

Author for correspondence.
Email: noemail@neicon.ru
Россия

E. M. Galkina

State budget educational institution of higher professional education “Saratov State Medical University named after V.I. Razumovsky” of Ministry of Health of the Russian Federation

Email: noemail@neicon.ru
Россия

A. V. Karakaeva

State budget educational institution of higher professional education “Saratov State Medical University named after V.I. Razumovsky” of Ministry of Health of the Russian Federation

Email: noemail@neicon.ru
Россия

M. V. Litvinenko

State budget educational institution of higher professional education “Saratov State Medical University named after V.I. Razumovsky” of Ministry of Health of the Russian Federation

Email: noemail@neicon.ru
Россия

References

  1. Mayes M.D. Epidemiology of systemic sclerosis and related diseases. Current Opinion in Rheumatology 1997; 9 (6): 557-561.
  2. Valentini G. & Black C. Systemic sclerosis. Best Practice and Research. Clinical Rheumatology 2002; 16 (5): 807-816.
  3. Steen V.D., Oddis C.V., Conte C.G. et al. Incidence of systemic sclerosis in Allegheny County, Pennsylvania. A twenty-year study of hospital-diagnosed cases, 1963-1982. Arthritis and Rheumatism 1997; 40 (3): 441-445.
  4. Feghali-Bostwick C., Medsger Jr. Ta & Wright T.M. Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies. Arthritis and Rheumatism 2005; 48 (7): 1956-1963.
  5. Lunardi C., Bason C., Navone Retal. Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus lateprotein UL94 and induce apoptosis in human endothelial cells. Natural Medicines 2000; 6 (10): 1183-1186.
  6. Assassi S. & Tan F. K. Genetics of scleroderma: update on single nucleotide polymorphism analysis and microarrays.Current Opinion in Rheumatology 2005; 17 (6): 761-767.
  7. Varga J. & Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. The Journal of Clinical Investigation 2007; 117 (3): 557-567.
  8. Helmbold P., Fiedler E., Fischer Metal. Hyperplasia of dermal microvascular pericytes in scleroderma. Journal of Cutaneous Pathology 2004; 31 (6): 431-440.
  9. Artlett C.M. Immunology of systemic sclerosis. Frontiers in Bioscience 2005; 10: 1707-1719.
  10. Takehara K. & Sato S. Localized scleroderma is an autoimmune disorder. Rheumatology (Oxford) 2005; 44 (3): 274-279.
  11. Baroni S.S., Santillo M., Bevilacqua F. et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. The New England Journal of Medicine 2006; 354 (25): 2667-2676.
  12. Hayakawa I., Hasegawa M., Takehara Ketal. AntiDNA topoisomerase IIalpha autoantibodies in localized scleroderma. Arthritis and Rheumatism 2004; 50 (1): 227-232.
  13. Pannu J. & Trojanowska M. Recent advances in fibroblast signal ing and biology in scleroderma. Current Opinion in Rheumatology 2004; 16 (6): 739-745.
  14. Asano Y., Ihn H., Jinnin M. et al. Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-betasignaling in dermal fibroblasts derived from localized scleroderma. The Journal of Investigative Dermatology 2006; 126 (8): 1761-1769.
  15. Tan F.K., Hildebrand B.A., Lester M.S. et al. Classification analysis of the transcriptosome of non-lesional cultured dermal fibroblasts from systemic sclerosis patients with early disease. Arthritis and Rheumatism 2005; 52 (3): 865-876.
  16. Chung L., Lin J., Furst D.E. et al. Systemic and localized scleroderma. Clinics in Dermatology 2006; 24 (5): 374-392.

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Copyright (c) 2016 Bakulev A.L., Galkina E.M., Karakaeva A.V., Litvinenko M.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


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