DIFFUSION NORMOLIPIDEMIC FLAT XANTHOMA, ASSOCIATED WITH HYPOCHROMIC ANEMIA. DESCRIPTION OF THE CASES

Cover Page

Cite item

Full Text

Abstract

The diffuse plane xanthoma (DPX) belongs to the class II of histiocytosis arising from the dermal dendritic cells (Histiocyte Society). The dominate role in the formation of the disease in the skin plays an accumulation of phagocytic immune complexes of macrophages. The clinical picture of the DPX is very specific and characterized by the appearance of periorbital xanthelasma and planar xanthomas on the skin of the trunk and extremities. The disease is often associated with hematological and lymphoproliferative diseases. The diagnosis is confirmed by histological examination.

About the authors

V. D. Elkin

“Perm state medical university by academician E. A. Wagner” of Ministry of Health of Russian Federation

Author for correspondence.
Email: sedovca-1978@yandex.ru
Petropavlovskaya str., 26, Perm, 614990, Russia Russian Federation

T. G. Sedova

“Perm state medical university by academician E. A. Wagner” of Ministry of Health of Russian Federation

Email: fake@neicon.ru
Petropavlovskaya str., 26, Perm, 614990, Russia Russian Federation

E. V. Plotnikova

“Perm state medical university by academician E. A. Wagner” of Ministry of Health of Russian Federation

Email: fake@neicon.ru
Petropavlovskaya str., 26, Perm, 614990, Russia Russian Federation

I. D. Kuznetsov

“Perm state medical university by academician E. A. Wagner” of Ministry of Health of Russian Federation

Email: fake@neicon.ru
Petropavlovskaya str., 26, Perm, 614990, Russia Russian Federation

M. U. Novoselova

“Perm state medical university by academician E. A. Wagner” of Ministry of Health of Russian Federation

Email: fake@neicon.ru
Petropavlovskaya str., 26, Perm, 614990, Russia Russian Federation

References

  1. Akhyani M., Daneshpazhooh M., Seirafi H., Naraghi Z. S. Diffuse plane xanthoma in an otherwise healthy woman. Clin Exp Dermatol 2001; 26 (5): 405—407.
  2. Altman J., Winkelmann R. K. Diffuse normolipemic plane xanthoma. Generalized xanthelasma. Arch Dermatol 1962; 85 (5): 633—640.
  3. Cambiaghi S., Boneschi V., Maffeis L., Gelmetti C. Diffuse normolipemic plane xanthoma in a child with common variable immunodeficiency. Pediatr Dermatol 2011; 28 (1): 62—66.
  4. Winkelmann R. K., McEvoy M. T. Diffuse-plane normolipaemic xanthoma with aortic-valve xanthoma. Clin Exp Dermatol 1991; 16 (1): 38—40.
  5. Buezo G. F., Porras J. I., Fraga J. et al. Coexistence of diffuse plane normolipaemic xanthoma and amyloidosis in a patient with monoclonal gammopathy. Br J Dermatol 1996; 135 (3): 460—462.
  6. Carlesimo M., Rossi A., La Pietra M. et al. Diffuse plane xanthoma and monoclonal gammopathies. Eur J Dermatol 2009; 19 (6): 640—641.
  7. Fichera G., Anastasio E., Capasso F. et al. Diffuse plane normolipemic xanthomatosis associated with Takayasu’s disease and hyperhomocysteinemia: a case report. Indian. J Dermatol Venereol Leprol 2004; 70 (4): 230—233.
  8. Ginarte M., Peteiro C., Toribio J. Generalized plane xanthoma and idiopathic Bence-Jones proteinuria. Clin Exp Dermatol 1997; 22 (4): 192—194.
  9. Kourou K., Suga Y., Muramatsu S. et al. A case of diffuse plane normolipemic xanthomatosis associated with pancytopenia and monoclonal gammopathy. J Dermatol 2006; 33 (1): 64—67.
  10. Rosmaninho A., Fernandes I., Guimas A. et al. Diffuse plane xanthomatosis associated with monoclonal gammopathy. An Bras Dermatol 2011; 86 (4): S50—S52.
  11. Da Silva D. M., Chacha J. J., Wiziack N. C. et al. Diffuse plane idiopathic normolipemic xanthoma with hypersplenism. An Bras Dermatol 2010; 85 (1): 73—76.
  12. Smith C. H., Barker J. N., Hay R. J. Diffuse plane xanthomatosis and acquired palmoplantar keratoderma in association with myeloma. Br J Dermatol 2006; 132 (2): 286—289.
  13. Stockman A., Delanghe J., Geerts M. L., Naeyaert J. M. Diffuse plane normolipaemic xanthomatosis in a patient with chronic lymphatic leukaemia and monoclonal gammopathy. Dermatology 2002; 204 (4): 351—354.
  14. Taylor J. S., Lewis L. A., Battle J. D. et al. Plane xanthoma and multiple myeloma with lipoprotein—paraprotein complexing. Arch Dermatol 1978; 114 (3): 425—431.
  15. Marcoval J., Moreno A., Bordas X. et al. Diffuse plane xanthoma: clinicopathologic study of 8 cases. J Am Acad Dermatol 1998; 39 (3): 439—442.
  16. Malbrán A., Parra L. S., Casas J. G. et al. Case report: diffuse plane xanthoma with low C4 and systemic inflammatory symptoms. Dermatol Online J 2009; 15 (4): 5.
  17. Lorenz S., Hohenleutner S., Hohenleutner U., Landthaler M. Treatment of diffuse plane xanthoma of the face with the Erbium: YAG laser. Arch Dermatol 2001; 137 (1): 1413 —1415.

Copyright (c) 2017 Elkin V.D., Sedova T.G., Plotnikova E.V., Kuznetsov I.D., Novoselova M.U.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies