Vol 93, No 4 (2017)

CLINICAL CASE REPORTS

DIFFUSION NORMOLIPIDEMIC FLAT XANTHOMA, ASSOCIATED WITH HYPOCHROMIC ANEMIA. DESCRIPTION OF THE CASES

Elkin V.D., Sedova T.G., Plotnikova E.V., Kuznetsov I.D., Novoselova M.U.

Abstract

The diffuse plane xanthoma (DPX) belongs to the class II of histiocytosis arising from the dermal dendritic cells (Histiocyte Society). The dominate role in the formation of the disease in the skin plays an accumulation of phagocytic immune complexes of macrophages. The clinical picture of the DPX is very specific and characterized by the appearance of periorbital xanthelasma and planar xanthomas on the skin of the trunk and extremities. The disease is often associated with hematological and lymphoproliferative diseases. The diagnosis is confirmed by histological examination.
Vestnik dermatologii i venerologii. 2017;93(4):62-65
pages 62-65 views

CONGENITAL EPIDERMOLYSIS BULLOSA: PECULIARITIES OF EPIDERMIS REGENERATION AND METHODS OF TREATMENT

Kubanov А.A., Karamova A.E., Al'banova V.I., CHikin V.V., Monchakovskaya E.S.

Abstract

Congenital epidermolysis bullosa is a group of hereditary skin diseases caused by mutations in the genes of structural proteins of the dermoepidermal junction of the skin, characterized by formation of blisters and erosions at the smallest mechanical trauma. In patients with severe subtypes of borderline and dystrophic epidermolysis bullosa there are long-term erosive and ulcerative defects with disruption of the healing process. Factors that impede healing include: malnutrition, anemia, pain, inactivity, local factors (presence of infection, prolonged inflammation, extensive nature of the lesion, absence of skin appendages in the affected area, deficiency or lack of formation of type VII collagen). Elimination of healing impeding factors is the main challenge in treatment of severe subtypes of bullous epidermolysis. Modern promising treatment techniques are at the stage of development and have not yet been introduced into clinical practice, and, as of today, skin care and optimal topical treatment with modern non-adhesive dressings remain the most widespread treatment methods that facilitate accelerated healing.
Vestnik dermatologii i venerologii. 2017;93(4):28-37
pages 28-37 views

ORGANIZATION OF HEALTH CARE AND EPIDEMIOLOGY

RESULTS OF WORK OF DERMATOVENEREOLOGIC HEALTHCARE ORGANIZATIONS IN 2016

Kubanova A.A., Kubanov A.A., Melekhina L.E., Bogdanova E.V.

Abstract

The paper presents the analysis of incidence of sexually transmitted infections and skin disorders in Russian Federation in 2016, the work and resources of dermatovenereologic healthcare organizations.
Vestnik dermatologii i venerologii. 2017;93(4):12-27
pages 12-27 views

GUIDELINES FOR PRACTITIONERS

EXPERIENCE OF REMOVING BENIGN NEOPLASMS OF SKIN IN CERVICOFACIAL AREA USING THE METHOD OF PLASMA ABLATION

Ritina I.F., Rubins S.A., Rubins A.Y.

Abstract

Choosing appropriate methods for removal of benign skin lesions (BSL) in the cervicofacial area has always been an important and challenging issue. Removal of the BSL is indicated and performed for medical and aesthetic reasons. A method with less painful procedures, a short healing period, without noticeable long-lasting traces (such as scars, dyschromia) and, predictably, fewer repeat procedures is preferred. Objectives. Evaluation of the effectiveness, safety and convenience of BSL plasma ablation using Plexr® (GMV, Italy); Comparison of the reparative processes speed after the BSL removal in the cervicofacial area applying the Plexr® device with other instrumental methods (based on literature reviews). Materials and Methods. We identified a group of patients wishing to remove papilloma, xanthelasma, dermal nevi, dermatofibroma on their face and body. Neoplasms (skin lesions) were assessed visually and by means of the Dermlite 3DN dermatoscope. Patients with atypical skin lesions were excluded from the study and referred to a medical oncologist for consultation. Each patient, having been fully briefed on the nature and course of the medical procedure, as well as required aftercare, submitted their written informed consent. Plasma ablation of BSL was performed using Plexr® device. Re-examination of patients was carried out after the scab from the treated area of the skin had fallen off. Results. We have performed 373 BSL removal procedures, including 212 (57%) — in the cervicalfacial area, among which there have been 47 (13%) cases of acrochordoni, papilloma, xanthelasma, syringoma and upper and lower eyelid milia removals. Complete healing has been recorded in 98% of all cases, with repeated corrective procedure being required only for one patient due to insufficiently deep tissues destruction in the course of multiple syringoma removal in the lower eyelid area. Conclusion. The results obtained allow to consider the method of BSL tissues plasma ablation applying Plexr® device effective, safe, non-traumatic, inexpensive, with a short period of tissue healing (7—10 days). BSL removal with the help of Plexr® — is a good alternative to conventional surgical and laser methods, which can be introduced into medical practice.
Vestnik dermatologii i venerologii. 2017;93(4):44-52
pages 44-52 views

VENOUS ECTASIA OF THE VERMILION BORDER: COPPER VAPOR LASER TREATMENT

Klyuchareva S.V., Ponomarev I.V., Andrusenko Y.N.

Abstract

We present the experience of application of "Yakhroma-Med" copper vapor laser system for the treatment of venouse ectasia (VE) of the vermilion border. The yellow wavelength of the generated laser radiation reaches 578 nm falls at the peak of hemoglobin absorption. The treatment was conducted in 58 patients with VE rising above the skin for no more than 1 mm. 100% clinical result. With a hemangioma size of up to 1 cm, treatment efficiency was 87% after the first procedure and complete resolution in 13% of the patients after the second procedure. At a size of more than 1 cm, the efficiency was 71% after the first procedure and 29% after the second. A 100% clinical result was obtained. The therapeutic effect persisted throughout the year in all 58 patients. It has been established that microcirculation disorders processes and further development of VE are affected by a variety of exogenous factors: about a half (48.3%) of the patients were deliberately subjected to excessive sunlight exposure, more than a quarter lived in regions with adverse climatic factors (wind, cold, abnormally low humidity, etc.) (27.6%), or regularly received hyperthermic procedures (steam bath, sauna, etc.) (25.9%). A burn (thermal, chemical) is found in the medical history of one in every five women (20.7%). 17.2% of the patients indulged in excessive consumption of condimental, spicy and hot food.
Vestnik dermatologii i venerologii. 2017;93(4):53-61
pages 53-61 views

SYSTEM THERAPY OF PSORIASIS IN CHILDREN (PART I)

Namazova-Baranova L.S., Murashkin N.N., Ambarchyan E.T., Materikin A.I.

Abstract

We include a review of modern methods of systemic therapy of psoriasis in children, indications for which are moderate and severe forms of psoriasis with PASI > 10, skin pathological process that is uncontrollable with topical drugs, skin lesions with functional localization (lesions of genitals, palms and soles, facial skin), erythrodermic psoriasis, pustular psoriasis, psoriatic arthritis. We provide information on the techniques of narrow-band phototherapy (UVB 311 nm) that are used in the treatment of psoriasis in children. We provide data on efficacy, safety, necessary monitoring of clinical and laboratory indicators, peculiarities of vaccination during treatment of children with acitretin, methotrexate, cyclosporine.
Vestnik dermatologii i venerologii. 2017;93(4):74-81
pages 74-81 views

BREACH OF SKIN BARRIER AS A LEADING FACTOR IN THE FORMATION OF LOCAL INFLAMMATORY PROCESS IN ATOPIC DERMATITIS.

Kudryavtseva A.V.

Abstract

Atopic dermatitis (also known as infantile eczema, atopic eczema) is a chronic inflammatory skin disease, accompanied by intense itching and continuously relapsing eczematous lesions. Despite the fact that the disease most often begins in early childhood, it is also quite widespread among adults. The disease is often accompanied by a fairly severe psychoemotional stress in both patients and their families, increases the risk of seasonal allergic rhinitis and asthma. Pathogenesis of atopic dermatitis is based on an imbalance in the proliferation of T lymphocytes towards the proliferation of Type 2 T helper cells with a high IgE response to allergens penetrating into the deep layers of the skin. A significant role is attributed to the colonization of the affected skin with Staphylococcus aureus. At present time, the disease is deemed to be an incurable condition, in which the failure of the epidermal barrier is considered to be the leading cause of onset of the disease. Prevention of breaches of the skin barrier, treatment of exacerbations of immuno-mediated inflammation of the skin with corticosteroids along with calcineurin inhibitors in the second line of therapy, as well as control of Staphylococcus skin infections retain their relevance.
Vestnik dermatologii i venerologii. 2017;93(4):82-89
pages 82-89 views

ISOTRETHINOINE IN ACNE THERAPY

Tlish M.M., SHavilova M.E.

Abstract

Systemic retinoids are known to be the most effective means of treating severe forms of acne. However, in spite of longstanding and intensive practice of their application in dermatology, some specialists still avoid prescribing this group of drugs. As a rule, this is due to lack of awareness of health professionals about therapy techniques and means of correcting possible adverse events. We discuss the clinical aspects of administration of isotretinoin in treatment of moderate and severe forms of acne. Practical recommendations are given on how to prevent various myths, misconceptions and prejudices in health professionals and patients. We present our own experience of using isotretinoin with increased bioavailability (Acnecutan®*).
Vestnik dermatologii i venerologii. 2017;93(4):90-96
pages 90-96 views

ASSOCIATED PATHOLOGY: CLINICAL ОBSERVATION

Tlish M.M., Popovskayа E.B., Sycheva N.L., Sorokina N.V., Psavok F.A.

Abstract

The article analyzes the literature on polymorbidity of immune dermatoses. They confirm the possibility of combining with each other immune diseases, due to the presence of immune and metabolic abnormalities that are characteristic for the majority of chronic dermatoses and may indicate the possibility of combining several nosology. We present 2 clinical cases polymorbidity. In the first case — a combination demonstrated in one patient planus, idiopathic atrophoderma Pasini — Pierini and multi-colored lichen. In the second case detected combination of 4 kinds of dermatological diseases — horny eczema, psoriasis vulgaris, scleroderma, and rosacea. Patients underwent complex clinical examination and histomorphological examination of skin biopsies. The presented clinical cases demonstrate the possibility of a combination of several skin diseases in one patient with common etiopathogenic mechanisms
Vestnik dermatologii i venerologii. 2017;93(4):66-73
pages 66-73 views

EFFECTIVENESS OF CREAM CONTAINING VERAPAMIL HYDROCHLORIDE, IN THE THERAPY OF RUBTS IN EXPERIMENT

Okhlopkov V.A., Skalsky S.V., Sokolova T.F.

Abstract

The data in respect to efficacy of verapamil-containing scar cream for treatment of hypertrophic and keloid scars are presented in the article. Skin scars were simulated in rats by excision of a full-thickness skin flap size 5x4 cm2 in the center of the back. Upon wound healing and scar formation a daily twofold fomentation of verapamil-containing cream was carried out. Treatment efficacy was checked after 10, 30 and 60 days. The following indices were studied: an area of the scar, its type, consistence, color, sensitivity, and scar microcirculation according to biomicroscopy. The proposed novel method for treatment of hypertrophic and keloid scars with verapamil-containing cream allowed to obtain a sustained clinical result demonstrating a reducing area of the scar by 25%, a physiological scar formation, improving the consistence and scar colour changing to the normal skin colour, its softening and flattening, and pain disappearance. Due to the dermal application, the method was painless, safety and did not affect on the surrounding tissues. According to biomicroscopy a scar remodeling approximated the indices to the level of healthy skin in 93% of rats. The most significant clinical effect the cream with verapamil was observed in experimental animals in 60 days after treatment.
Vestnik dermatologii i venerologii. 2017;93(4):38-43
pages 38-43 views

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