Сlinical case of a blast plasmocytoid dendritic cell tumor

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Abstract


The reason for writing this article was the difficulty in the differential diagnosis of skin lesions in a patient of 40 years, with a preliminary diagnosis of T-cell lymphoma. During the examination, including histological, immunomorphological, immunohistochemical methods, markers of various cell lines (T, B, myeloid) were detected. This feature is characteristic of lymphomas from plasmacytoid dendritic cells (MAC), a new nosological unit. In the WHO classification (2001), tumors with a similar phenotype were included in the lymphoma section of natural killer cells (NK-blast lymphomas). The clinical case described by us illustrates the need for an integrated approach in the diagnosis of lymphomas, which makes it possible to promptly assign adequate therapy.

About the authors

E. N. Milikhina

4 Military Hospital of the National Guard of the Russian Federation

Email: fake@neicon.ru

Russian Federation

Dermatovenerologist,

Luganskaya str., 57, Kirov, 610044

T. V. Chermnykh

4 Military Hospital of the National Guard of the Russian Federation

Email: fake@neicon.ru

Russian Federation

Dermatovenerologist,

Luganskaya str., 57, Kirov, 610044

S. V. Koshkin

Kirov State Medical University, Ministry of Health of the Russian Federation

Author for correspondence.
Email: koshkin_sergei@mail.ru

Russian Federation

Dr. Sci. (Med.), Prof., Head of Department, Department of Dermatovenereology and Cosmetology,

Karla Marksa str., 112, Kirov, 610027

O. D. Maximov

Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical Biological Agency of the Russian Federation

Email: fake@neicon.ru

Russian Federation

Hematologist,

Krasnoarmeyskaya str., 72, Kirov, 610027

References

  1. Swerdlow S. H., Campo E., Harris N. L., Jaffe E. S., Pileri S. A., Stein H. et al. (eds) WHO classification of tumor of haemotopoietic and lymphoid tissues. 4th ed., revised. 2017.
  2. Burg G., Kempf W., Cozzio A., Feit J., Willemze R., Jaffe E. et al. WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects. J Cutan Pathol. 2005;32(10):647–674.
  3. Галил-Оглы Г. А., Молочков В. А., Сергеев Ю. В. Дерматоонкология. М.: Медицина для всех, 2005. С. 481–634. [Galil-Oglyi G. A., Molochkov V. A., Sergeev Yu. V. Dermatooncology. Moscow: Meditsina dlya vseeh, 2005. P. 481–634. (In Russ.)]
  4. Молочков А. В., Ковригина А. М., Кильдюшевский А. В., Караулов А. В. Лимфома кожи. М.: БИНОМ, 2012. 184 с.
  5. Kempf W. CD30 lymphoproliferative disorders: histopathology, differential diagnosis, new variants and simulators. J Cutan Pathol. 2006;33(Suppl. 1):58–70.
  6. Facchetti F., Cigognetti M., Fisogni S., Rossi G., Lonardi S., Vermi W. Neoplasms derived from plasmacytoid dendritic cells. Mod Pathol. 2016;29(2):98–111.
  7. Cui X. B., Jin J., Pang X. L., Li S., Liu C. X., Li T. T. et al. A case of blasticplasmacytoid dendritic cell neoplasm with ecchymotic lesions on the whole body. Int J Clin Exp Pathol. 2014;7(7):4391–4399.
  8. Глузман Г. Ф. Диагностическая онкогематология. Киев: ДИА 2011. 256 с.
  9. Lee M., Kim I.-S., Lee J. N., Park S. H., Kim H.-H., Chang Ch. L. et al. Acute Myeloid Leukemia with MLL Rearrangement and CD4+ /CD56+ Expression can be Misdiagnosed as Blastic Plasmacytoid Dendritic Cell Neoplasm: Two Case Reports. Ann Lab Med. 2016;36(5):494–497.
  10. Laribi K., Denizon N., Besançon A., Farhi J., Lemaire P., Sandrini J. et al. Blastic Plasmacytoid Dendritic Cell Neoplasm: From Origin of the Cell to Targeted Therapies. Biol Blood Marrow Transplant. 2016;22(8):1357–1367.

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