Modern pathogenetic therapy of acne

Cover Page


Cite item

Full Text

Abstract

The article provides an overview of literature on new data in studying acne pathophysiology. A particular attention is given to modern interpretation of the role played by inflammation in dermatosis development. The author presents an analysis of the most effective modern pathogenetically-based topical preparations, as well as an algorithm for their application.

About the authors

A. V. Samtsov

S. M. Kirov Military Medical Academy, Ministry of Defence of the Russian Federation

Author for correspondence.
Email: avsamtsov@mail.ru
Dr. Sci. (Med.), Prof., Departmental Head, Department of Skin and Venereal Diseases Россия

References

  1. Zaenglein А., Pathy А., Schlosser В. et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. DOI: 10.1016/j. jaad.2015.12.037
  2. Thiboutot D., Gollnick H. New insights into the management of acne: an update from the Global Alliance to improve outcomes in acne group. J Am Acad Dermatol. 2009;60:1–50.
  3. Dreno B., Gollnick H., Kang S. et al. Understanding innate immunity and inflammation in acne: implications for management. JEADV. 2015;29 (Suppl 4):3–11.
  4. Gollnick H. From new findings in acne pathogenesis to new approaches in treatment. JEADV. 2015;29:1–7.
  5. Jeremy A. H., Holland D. B., Roberts S. G., Thomson K. F., Cunliffe W. J. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol. 2003;121:20–27.
  6. Lee W., Jung H., Chi S. et al. Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes. Arch Dermatol Res. 2010;302:429–433.
  7. Shaheen B., Gonzales M. Acne sans P. acnes. JEADV. 2013;27:1–10.
  8. Kim J., Ochoa М., Krutzik S. et al. Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses. J Immunology. 2002;169:1535–1541.
  9. Vowels B., Yang S., Leyden J. Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes — implications for chronic inflammatory acne. Infect Immun. 1995;63:3158– 3165.
  10. Ichiyasu H., Suga M., Matsukawa A. et al. Functional roles of MCP-1 in Propionibacterium acnes-induced, T cellmediated pulmonary granulomatosis in rabbits. J Leukocyte Biology. 1999;65:482–491.
  11. Itakura M., Tokuda A., Kimura H. et al. Blockade of Secondary Lymphoid Tissue Chemokine Exacerbates Propionibacterium acnes-Induced Acute Lung Inflammation. J Immunology. 2001;166:2071–2079.
  12. Webster G. Commentary: Diet and acne. J Am Acad Dermatol. 2008;58:794–795.
  13. Lodes M., Secrist H., Benson D. et al. Variable expression of immunoreactive surface proteins of Propionibacterium acnes Microbiology. 2006;152:3667–3681.
  14. Zaenglein A., Thiboutot D. Expert Committee Recommendations for Acne Management. Pediatrics. 2006;118:1188–1199.
  15. Самцов А. В., Аравийская Е. А. Федеральные клинические рекомендации по ведению больных акне. Под ред. А. А. Кубановой. 2018. [Samtsov A. V., Araviyskaya E. A. Federal clinical guidelines for treating patients with acne. Еd. by A. A. Kubanova. 2018 (In Russ.)]]
  16. Leccia M. et al. Topical acne treatments in Europe and the issue of antimicrobal resistance. JEADV. 2015;29:1485–1492.
  17. Simonart T., Dramaix M. Treatment of acne with topical antibiotics: lessons from clinical studies. Br J Dermatol. 2005;153:395–403.
  18. Heba A., Alan S. Topical Clindamycin Preparations in the Treatment of Acnes Vulgaris. Exp Rev Dermatol. 2009;4(2):1–8.
  19. Wolf J. E., Kaplan D., Kraus S. Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study. Randomized controlled trial. J Am Acad Dermatol. 2003;49 (Suppl):211–217.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Samtsov A.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies