Current drugs acting on Toll-like receptors in the treatment of inflammatory dermatoses M.A. iONESCU



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Abstract

The article presents the results of a study of the oil-in-water emulsion comprising TLR2-regul®, a complex patented by Uriage Laboratories. At the first stage of the study, skin explants from healthy donors were incubated in the physiological salt solution, oil-in-water indifferent cream excipient, with monoclonal anti-TLR2 antibodies and with the oil-in-water study emulsion, and then samples in each groups were divided into three sub-groups and incubated with extracts of M. furfur, p. acnes и S. aureus. The immune-enzyme assay method demonstrated a significant reduction in the production of IL-8 and higher quantity of β-defensin 2 in case of incubation with the study emulsion vs. the control group. At the second stage, the authors assessed the efficiency of the study emulsion in the treatment of patients suffering from seborrheic dermatitis (n = 143), acne (n = 34) and atopic dermatitis (n = 48) as a monotherapy vs. the cream base. After four weeks, patients with seborrheic dermatitis had a considerable reduction of erythema, peeling, itching and stinging, reduction in the number of recurrences; after three months, the group of acne patients had a considerably reduced number of inflammatory elements; after three weeks of treatment, patients with atopic dermatitis had a considerable reduction of erythema, infiltration and exudation as well as itching and shrinking. Thus, the study drug suggests new approaches to the treatment of inflammatory skin diseases with the pathogenesis complicated by P. acne, S. aureus or M. furfur due to its ability to modulate the immune response.

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Современные средства, воздействующие на Тоll-подобные рецепторы, в лечении воспалительных дерматозов
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About the authors

M A lonescu

Hopital Saint-Louis

Email: dr.toni.ionescu@gmail.com
M.D., dermatologist. Polyclinique de dermatologie. Paris, France

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