Pathogenic therapy of acne patients

Cite item


The authors provide a detailed description of the composition, pharmacokinetic and pharmacodynamic properties of Acnecutan, an innovation drug for the system pathogenic therapy of acne. They present the results of clinical observations and treatment of 88 patients suffering from moderate to severe acne forms with Acnecutan.

Full Text

Патогенетическая терапия больных акне


  1. Gollnick H., Cunliffe W., Berson D. et al. Management of acne: a report from a global alliance to improve outcomes in acne. J Am Acad Dermatol 2003; 49: 1—37.
  2. Plewig G., Kligman A. Acne & rosacea. 3rd ed., Berlin: Springer 2002.
  3. Zouboulis C.C., Eady A., Philpott M. et al. What is the pathogenesis of acne? Exp Dermatol 2005; 14: 143—152.
  4. Kuwahara K., Kitazawa T., Kitagaki H. et al. Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes. J Dermatol Sci 2005; 38: 47—55.
  5. Leyden J.J. Therapy for acne vulgaris. N Engl J Med 1997; 336: 1156—1162.
  6. Hoeffler U. Enzymatic and hemolytic properties of Propionibacterium acnes and related bacteria. J Clin Microbiol 1977; 6: 555—558.
  7. Jeremy A.H., Holland D.B., Roberts S.G. et al. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 2003; 121: 21—27.
  8. Kurokawa I., Mayer-da-Silva A., Gollnick H., Orfanos C.E. Monoclonal antibody labeling for cytokeratins and filaggrin in the human pilose-baceous unit of normal, seborrhoeic and acne skin. J Invest Dermatol 1988; 91: 566—571.
  9. Layton A.M., Morris C., Cunliffe W.J., Ingham E. Immunohistochemical investigation of evolving inflammation in lesions of acne vulgaris. Exp Dermatol 1998; 7: 191—197.
  10. Thiboutot D.M., Knaggs H., Gilliland K., Hagari S. Activity of type 1,5 Alphareductase is greater in the follicular infrainfundibulum compared with the epidermis. Br J Dermatol 1997; 136: 166—171.
  11. Регистрационное досье на препарат «Акнекутан» от производителя СМБ Технолоджи С.А.
  12. Отчет от производителя СМБ Технолоджи С.А. по исследованию ISOPK 03.04 Version 1. 2003.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies