Immune and genetic mechanisms of infertility andreproductive function disorders associated with humanurogenital chlamydial infection

Abstract

This review covers current concepts of immune and genetic mechanisms of infertility associated with human urogenital chlamydial
infection. It describes studies of individual polymorphisms of genes coding cytokines and other immune system mediators. It also
presents the results of studies aimed at searching for genetic predisposition to the development of complications resulting in human
reproductive function disorders caused by past urogenital chlamydial infections.

References

  1. Moss T.R. Darougar R. Human genital infections with C. trachomatis. UK, 2008; 55-73.
  2. Kohl K.S., Markowitz LE, Koumans EH. Developments in the screening for Chlamydia trachomatis: a review. Obstet Gynecol Clin North Am. 2003; 30 (4): 637-58.
  3. Анри-Сюше Ж. Хламидиозы в гинекологии. Актуальные микробиологические и клинические проблемы хламидийных инфекций. М., 1990. С. 16-30;
  4. Kleimann D., Sarov I., Insler V. The effects of contraceptive hormones on the replication of Clamydia trachomatis in human endometrial cells. Contraception. 1987; 35 (6): 533-542.
  5. Ripa K.T. Biological principles of the culture of Clamydia trachomatisin cells monolayers. Acta pathol., microb., immunol. Scand. 1982; 32: 4-8.
  6. Domeika M., Mardh P.A. ABC on Chlamydia. Syva a Syntex Company, Berkshire, 1993.
  7. Kamwendo F, Forslin L, Bodin L, Danielson D. Decreasing incidences of gonorrhea- and chlamydia-associated acute pelvic inflammatory disease: a 25-year study from an urban area of central Sweden. Sex Transmit Dis. 1996; 23: 384-91.
  8. Ustacelebi S, Kultursay N. Human Chlamydial infection. Ed. D. Serter, E. Ertem, D. Dereli. - Izmir. 1997; 29-37.
  9. Г.Ф. Железникова. Цитокины как предикторы течения и исхода инфекций. Цитокины и воспаление. 2009; 8 (11): 10-17.
  10. Malinverni R. The role of cytokines in chlamydial infections. Curr. Opin. Infect. Dis. 1996; 9: 150-155.
  11. Morton R.S., Kinghorn G.R. Genitourinary chlamydial infection: a reappraisal and hypothesis. Int. J. STD AIDS. 1999; 10: 765-755.
  12. Zdrodowaska-Stefanow B., Ostaszewska-Puchalska I., Pucilo K. The immunology of Chlamydia trachomatis. Archivum Immunologiae et Therapiae Experimentalis. 2003; 51: 289-294.
  13. Rusmussen S.J., Eckmann L., Quayle A.J. et al. Secrection of proinflammantory cytokines by epithelial cells in response to Chlamytia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J. Clin. Invest. 1997; 99: 77-87.
  14. Witkin S.S., Giraldo P., Linhares I. et al. Individual immunity and susceptibility to female genital tract infection. Am. J. Obstet. Gynecol. 2000; 183: 252-256.
  15. Дмитриев Г.А. Наиболее распространенные урогенитальные инфекции: диагностика и терапия. Consilium Medicum. 2004; 5 (7).
  16. Sellors J, Howard M, Pickard L, Jang D, Mahony J, Chernesky M. Chlamydial cervicitis: testing the practice guidelines for presumptive diagnosis. CMAJ. 1998; 158 (1):65.
  17. Witkin SS. Immunity to heat shock proteins and pregnancy outcome. Infect Dis Obstet Gynecol 1999; 7: 35-8
  18. Dreesbach K. Review. Chlamydial Heat Shock Proteins (sHSP). Germany, Medac Diagnostic. 2001; 1-19.
  19. Claman P, Honey L, Peeling RW, Jessamine P, ToWitkin SS. Immunity to heat shock proteins and pregnancy outcome. Infect. Dis. Obye B: The presense of serum antibody to the chlamidial heat shock protein (CHSP60) as a diagnostic test for tubal factor infertility. Fertil Steril. 1997; 67: 501-4.
  20. Paavonen J. Immunopathogenesis of pelvic inflamantory disease and infertility - what do we know and what shal we do? J. Br. Fert. 1996; 1: 42-5.
  21. Debattista J, Timms P, Allan J. Immunopathogenesis of Chlamydia trachomatis infections in women. Fertil Steril. 2003; 79: 1273-7.
  22. Moore K.W., R de Waal Malefyt, R. L. Coffman and A. O'Garra. Interleukin-10 and interleukin-10 receptor. Annu. Rev. Immunol. 2001; 19: 683-765.
  23. Rotterberg ME, Gigliotti-Rothfunchs A, Wigzell H. The role of IFN-gamma in the outcome of chlamydial infection. Curr Opin Immunol. 2002; 14: 444-451.
  24. Reddy BS, Rastogi S, Das B et al. Cytokyne expression pattern in the genital tract of Chlamydia trachomatis positive infertile women - implication of T-cell responses. Clin.Exp Immunol. 2004; 137: 552-558.
  25. Srivastva P, Jha R., Bas S. In in fertile women, cells from Chlamydia trachomatis infected site release higher levels of interferon-gamma, interleikin-10 and tumor necrosis factor-alpha upon heat shock protein stimulation then fertile women. Biology and Endocrinology. 2008; 6: 20.
  26. M.J. Vignola, D.F. Kashatus, G.A. Taylor et al. cPLA2 regulates the expression of Type I interferons and intracellular immunity to Chlamydia trachomatis. J Biol Chem. Jul 2010; 285 (28): 21625-35.
  27. Сметник В.П., Тумилович Л.Г. Неоперативная гинекология. Руководство для врачей. СПб.: СОТИС, 1995. 224 с.
  28. Munday PE. Clinical aspects of pelvic inflammatory disease. Hum Reprod. Nov 1997; 12 (11): 121-6.
  29. Канищева Е.Ю. Воспалительные заболевания органов малого таза у женщин и их связь с инфекциями, передаваемыми половым путем. Диагностика, лечение. Вестн. дермат. и венер. 2002; 4: 16-23.
  30. Современные подходы к лечению воспалительных заболеваний женских половых органов. Метод. материалы. / под ред. В.Н. Серова. М., 2003.
  31. Сидельникова В.М. Неполноценная лютеиновая фаза - тактика ведения пациенток с привычной потерей беременности. Гинекология. 2002; 4: 154-155.
  32. Ingman W.V., Jones R.L. Cytokine knockouts in reproduction: the use of gene ablation to dissect roles of cytokines in reproductive biology. Human reproduction update. 2008; 24 (3): 179-192.
  33. Beer AE, Kvark JY. Reproductive medicine program. Finch University of Health Science Chicago Medical School. 2000.
  34. Beatty W.L., Byrne G.L., Morrison R.P. Morphologic and antigenic characterization of interferon - γ- mediated persistent Chlamydia trachomatis infection in vitro. Proc. Natl. Acad. Sci. USA. 1993; 90: 3998-4002.
  35. Claman P, Honey L, Peeling R W, Jessamine P., Toye B: The presence of serum antibody to the chlamydial heat shock protein (CHCP60) as a diagnosic test for tubal factor infertility. Fert. Steril. 1997; 67: 501-504.
  36. Cotter TW, Meng Q, Shen ZL, Zhang YX, Su H and Caldwell HD: Protective efficacy of major outer membrane protein- specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection. Infect Immun. 1995; 63: 4704-4714.
  37. Couper KN, Blount DG, Riley EM. IL-10: the master regulator of immunity to infection. J Immunol 2008; 180: 5771-7.
  38. Abbas Z., Moatter T., Hussainy A., Jafri W. Effect of cytokine gene polymorphism on histological activity index, viral load and responcse to treatment in patients with chronic hepatitis C genotype 3. World J Gastroenterol. 2005; 11 (42): 6656-61.
  39. Yanina Eberhard, Mamyrova G, Hanlon T.P., Sillers L. et al. Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis. Arthritis and Rheumatism. 2008; 58(12): 3941-50.
  40. Öhman H., Triitinen A., Halttunen M., et al. Cytokine polymotphisms and severity of tubal damage in womaen with Chlamydia-associated infertility. The journal of infectious diseases. 2009; 199: 1353-9.
  41. Hvid, M., A. Baczynska, B. Deleuran, J. Fedder, H. Knudsen, G. Christiansen, and S. Birkelund. Interleukin-1 is the initiator of Fallopian tube destruction during Chlamydia trachomatis infection. Cell. Microbiol. 2007; 9: 2795-2803.
  42. Öhman H., Triitinen A., Halttunen M., et al. IL-10 polymorphism and cell-mediated immune response to Chlamydia trachomatis. Genes and Immunity. 2006; 7: 243-6.
  43. Rasouli M., Kiany S. Association of interferon-gamma and interleukin- 4 gene polymorphisms with susceptibility to brucellosis. Cytokine. 2007; 38: 49-4.
  44. Kinnunen et al., 2002; Mei В., Luo Q., Du K. et al., Assotiation of MICA gene polymorphisms with Chlamydia trachomatis infection and related tubal pathology in infertile woman. Hum Reprog. 2009; 24912: 3090-5.
  45. Worthley D.L., Bardy P.G., Mullighan C.G. Mannose-binding lectin: biology and clinical implications. Intern Med J. 2005; 35 (9): 548-55.
  46. Fraser I.P., Koziel H., Ezekowitz R.A. The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity. Semin Immunol. 1998; 10 (5): 363-72.
  47. Sziller I., Babula O., Ujházy A., Nagy B., Hupuczi P., Papp Z., Linhares I.M., Ledger W.J., Witkin S.S. Chlamydia trachomatis infection, Fallopian tube damage and a mannose-binding lectin codon 54 gene polymorphism. Hum Reprod. 2007; 22 (7): 1861-5.

Copyright (c) 2010 Plakhova K.I., Rakhmatulina M.R., Frigo N.V., Galimov A.R., Volkov I.A., Vasil'eva E.L., Plakhova K.I., Rakhmatulina M.R., Frigo N.V., Galimov A.R., Volkov I.A., Vasiliyeva Y.L.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies