Results of an experimental study of the UV radiation effect on the photosensitive skin protein

Abstract


TsPO (18 kDa translocator protein) is a photosensitive protein regulating processes of skin proliferation and apoptosis. Changes
in the conformational properties of TsPO correlate with the intensity of cell proliferation. Changes in the TsPO level in the ratsskin after exposure to UV radiation were assessed with the use of immunohistochemical staining. It was revealed that the dose of 200 J/m2 causes a unidirectional increase in the TsPO and PCNA (a cell proliferation marker) levels in the skin. UV radiation in the doses of 400-600 J/m2 induces a reduction of TsPO and PCNA expression. Thus, there is a possibility that TsPO participates in the regulation of changes in the intensity of cell proliferation in the skin under the exposure to UV radiation.

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Copyright (c) 2010 Savchenko I.A., Ruksha T.G., Salmin V.V., Zykova L.D., Savchenk o I.A., Ruksha T.G., Salmin V.V., Zykova L.D.

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