Efficacy of repeated treatment courses of lactulose as a component of complex therapy in patients with psoriasis

The results of complex investigation performed in 117 patients with progressing psoriasis are reported below. It is estimated that in case of psoriasis progression there are evidences of an excessive accumulation of low and mean molecular substances of catabolic origin in plasma and urine that accompanies to activation of the endotoxin elimination system. The intensity of endotoxicosis syndrome is interrelated with the presence of the intestinal indigestion and the severity degree of dysbiosis. An addition of lactulose (Duphalac, Solvey-Pharma) to the complex therapy of patients with psoriasis aggravation using 25 ml of the drug solution for 21 days lead to significant improvement of the endoscopic picture in the large intestine, a reduction of endogenous intoxication severity and is accompanied by marked clinical benefit.

psoriasis, endogenous intoxication, dysbiosis, lactulose