Assessment of the efficacy of antihistamine drugs in complex treatment of chronic itchingdermatoses



Cite item

Full Text

Abstract

The authors give a review of current concepts of mechanisms of skin itching development for different types of chronic
dermatoses. The authors also present the results of a study aimed at assessing the efficacy of different 2nd generation
antihistamine drugs used for complex treatment of 83 patients aged 14-73 suffering from different chronic itching
dermatoses (atopic dermatitis, eczema, pruritus, chronic urticaria, progressing psoriasis, lichen acuminatus, contact
allergic dermatitis).
The authors conclude that Glencet (levocetirizine) used in a complex therapy of dermatoses accompanied with itching
can efficiently arrest both subjective itching sensations and objective clinical symptoms of the diseases as well as reliably
(р < 0.001) reduce the term of inpatient care by 4.8 ± 2.3 on average.
Glencet (levocetirizine) is a drug of choice among the 2nd generation antihistamine drugs used for treatment of chronic
skin diseases accompanied with itching.

References

  1. Соколовский Е.В. Кожный зуд. Акне. Урогенитальная хламидийная инфекция. СПб.: «СОТИС» 1988; 3-67.
  2. Торопина Г.Г., Иванов О.Л., Львов А.Н. Инновационные методы нейрофизиологического исследования механизмов зуда у больных атопическим дерматитом. Росс. журн. кожн. и венерич. бол, 2009; 4: 28-31.
  3. O'Neill J.L., Chan Y.H., Rapp S.R. Differences in itch characteristics between psoriasis and atopic dermatitis patients: results of a webbased questionnaire. Acta Derm Venereol. 2011 Apr 29 [Epub ahead of print].
  4. Devalia J.L., de Vos C., Hanotte F. et al. A randomized double-blind crossover comparison among cetirizine, levocetirizine and UCB 28557 on histamine-induced cutaneous responses in healthy adult volunteers. Allergy 2001; 56: 50-7.
  5. Salmun L.M. Antihistamines in late-phase clinical development for allergic disease. Expert Opin Invest Drugs 2002; 11: 259-73.
  6. Гребенченко Е.И., Гущин К., Феденко Е.С. Механизм кожного зуда при атопическом дерматите. Рос. аллергол. журн. 2009; 3: 3-11.
  7. Эбаноидзе Т., Беридзе Л., Твалиашвили Г. Нейроанатомические и нейрофизиологические аспекты зуда в лечении атопического дерматита. Аллергология и иммунология, 2010; 11: 2: 92-93.
  8. Свирщевская Е.В., Матушевская Е.В., Матушевская Ю.И. Патофизиология зуда при некоторых дерматозах. Росс. журн. кожн. венерич. болезней. 2009; 1: 19-23.
  9. Chen C. Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. Curr Med Chem 2008; 15 (21): 2173-2191.
  10. Львов А.Н., Грундманн С., Штендер С. Хронический зуд: старые проблемы, новые решения. Росс. журн. кожн. венерич. болезней, 2010; 4: 7-12.
  11. Klimek L. Levocetirizine: from scientific evidence to a potent modern-day treatment of today's allergic patients. Drugs Today (Barc) 2009 (Mar); 45 (3): 213-225.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Murashkin N.N., Gluzmin M.I., Materikin A.I., Murashkin N.N., Gluzmin M.I., Materi kin A.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies