Up-to-date non-invasive visualization technologies in dermatology

Abstract

The authors present a review of up-to-date non-invasive visualization methods used in diagnostics of diseases of skin
and its appendages. They describe physical principles forming the basis for non-invasive visualization methods such
as dermatoscopy, confocal laser scanning microscopy, optical video monitoring, optical topometry, optical coherent
tomography, ultrasound scanning, 3D-modeling. They also describe the potential of practical application of these diagnostics
methods at the current stage of their development. The authors have demonstrated that it is possible to reduce the clinicians
need in biopsy diagnostics due to the high information value of non-invasive visual diagnostics methods.

References

  1. Котова О.Е. Аутофлюоресцентная диагностика рецидива базально-клеточного рака кожи. Врач-аспирант, июнь 2006; vrach-aspirant.ru
  2. Резайкин А.В., Кубанова А.А., Резайкина А.В. Неинвазивные методы исследования кожи. Вестн. дерматол. и венерол., 2009; 6: 28-32.
  3. Tearney G.T., Brezinski M.E., Southern et al. Determination of the refractive index of highly scattering human tissue by optical coherence tomography. Opt Lett 1995; 20: 2258-2260.
  4. Gambichler T., Boms S., Stücker M et al. Epidermal thickness assessed by optical coherence tomography and routine histology: preliminary results of method comparison. J Eur Acad Dermatol Venerol 2006; 20: 7: 791-795.
  5. Mansotti L. Basic principles and advanced technical aspects of ultrasound imaging. In: Physics and Engineering of Medical Imaging (Guzzardi, R., ed.), pp. 263-317. Springer, the Netherlands 1987.
  6. Самцов А.В., Барбинов В.В., Казаков Д.В. Дерматология накануне ХХI века. Вестн. дерматол. и венерол., 2001; 2: 14-17.
  7. New K.C., Petroll W.M., Boyde A. et al. In vivo imaging of human teeth and skin using real-time confocal microscopy. Scanning 1991; 13: 369-372.
  8. Rajadhyaksha M., Grossman M., Esterowitz D. et al. In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol 1995; 104; 946-952.
  9. Corcuff P, Lévêque JL. In vivo vision of the human skin with the tandem scanning microscope. Dermatology 1993; 186: 50-54.
  10. Иванова Е.В., Ткаченко С.Б., Кузьмина Т.С. Возможности оптического видеомониторинга в оценке состояния микрорельефа кожи. Эксперим. и клин. дерматокосметол., 2007; 3: 43-45.
  11. Балбашев А. Возможности оптической топометрии кожи и 3D-моделирования в дерма- токосметологии и эстетической медицине. Косметика & медицина, 2008; 4: 54-59.
  12. Stolz W., Bilek P., Burgdorf W.H.C. Color Atlas of Dermatoscopy, 2nd edition. Blackwell Publishing 2002.
  13. Kittler H., Pehamberger H., Wolff K. et al. Diagnostic accuracy of dermoscopy. Lancet Oncol 2002; 3: 159-65.
  14. van der Rhee J.I., Bergman W., Kukutsch N.A. The impact of dermoscopy on the management of pigmented lesions in everyday clinical practice of general dermatologists: a prospective study. Br J Dermatol 2010; 162: 563-56.
  15. Westerhoff K., McCarthy W.H. et al. Increase in the sensitivity for melanoma diagnosis by primary care physicians using skin surface microscopy. Br J Dermatol 2000; 143: 1016-20.
  16. Crotty K.A., Menzies S.W. Dermoscopy and its role in diagnosing melanocytic lesions: a guide for pathologists. Pathology 2004(Oct); 36(5): 470-477.
  17. Bauer J., Metzler G., Rassner G. et al. Dermatoscopy turns histopathologist's attention to the suspicious area in melanocytic lesions. Arch Dermatol 2001; 137: 1338-40.
  18. Marghoob A.A., Braun R.P., Kopf A.W. Atlas of Dermoscopy. Informa Healthcare 2005.
  19. Gewirtzman A.J., Saurat J-H., Braun R.P. An evaluation of dermoscopy fluids and application techniques Br J Dermatol 2003; 149: 59-63.
  20. Wang S.Q., Dusza S.W., Scope A. et al. Differences in dermoscopic images from nonpolarized dermoscope and polarized dermoscope influence the diagnostic accuracy and confidence level: a pilot study. Dermatol Surg 2008 Oct;34(10): 1389-95.
  21. Soyer H.P., Argenziano G., Hofmann-Wellenhof R., Johr R.H. (Eds.) Color Atlas of Melanocytic Lesions of the Skin. Berlin, Heidelberg: Springer-Verlag 2007.
  22. Green W.H., Wang S.Q., Cognetta A.B. Total-body cutaneous examination, total-body photography, and dermoscopy an the care of a patient with xeroderma pigmentosum and multiple melanomas. Arch Dermatol 2009; 145(8): 910-915.
  23. Psaty E.L., Scope A., Halpern A.C., Marghoob A.A. Defining the patient at high risk for melanoma. Int J dermatol 2010; 49: 4: 362-376.
  24. Inui S., Nakajima T., Nakagawa K. et al Clinical significance of dermoscopy in alopecia areata: analysis of 300 cases International Journal of Dermatology 2008, 47, 688-693.
  25. Lee D-Y., Lee J-H., Yang J-M. et al. The use of dermoscopy for the diagnosis of trichotillomania. J Eur Acad Dermatol Venerol 2009; 23: 731-732.
  26. Cabrera R., Daza F. Dermoscopy in the diagnosis of tungiasis. Br J Dermatol 2009 May; 160(5): 1136-7.
  27. Zalaudek I., Giacomel J., Cabo H. et al. Entodermoscopy: a new tool for diagnosing skin infections and infestations. Dermatology 2008; 216(1): 14-23.
  28. Braun R.P., Oliviero M., Kolm I. et al. Dermoscopy: what's new? Clin Dermatol 2009 (Jan-Feb); 27(1): 26-34.
  29. Hirata S.H., Yamada S., Almeida F.A. et al. Dermoscopic examination of the nail bed and matrix. Int J Dermatol. 2006 Jan; 45(1): 28-30.
  30. Richtig E., Hofmann-Wellenhof R., Kopera D. et al. In vivo analysis of solar lentigines by reflectance confocal microscopy before and after Q-switched ruby laser treatment. Acta Derm Venereol 2011 (Mar); 91(2): 164-8.
  31. Петрова Г.А., Дерпалюк Е.Н., Гладкова Н.Д. и др. Оптическая когерентная томография в прижизненной диагностике дерматозов и мониторинге структурных изменений кожи. Росс. журн. кожн. и венерич. болезней, 2005; 3: 16-23.
  32. Петрова Г.А., Петрова К.С., Шливко И.Л. и др. Экспериментальная идентификация компонентов ОКТ-изображений здоровой тонкой кожи человека. Росc. журн. кожн. и венерич. болезней, 2008; 6: 53-58.
  33. Dreijer N. Diagnostic ultrasound. Naerum: Brüel and Kjær, 1979.
  34. Serup J., Keiding J., Fullerton A. et al. Highfrequency ultrasound examination of skin: introduction and guide. In: Serup J, Jemec GBE, eds. Handbook of non-invasive methods and the skin. Boca Raton: CRC Press, 1995: 239-56.
  35. Agner T. Ultrasound A-mode measurement of skin thickness, in Handbook of noninvasive methods and the skin. Boca Raton: CRC Press 1995; 1: 289-292.
  36. Altmeyer P., Hoffmann K., Stucker M. et al. Phenomena of Ultrasound in Dermatology 1992; 55-79.
  37. Alexander H., Miller D.L. Determining skin thickness with pulsed ultrasound. J Invest Dermatol 1979; 72: 17-9.
  38. Hoffmann K., Dirting K., Stücker M. et al. Geschichte der hochfrequenten Sonographie. Ultraschall Med 1994; 15: 192-7.
  39. Freitag M., Hoffmann K., Altmeyer P. Nichtinvasive hochauflosende Sonographis des malignen Melanoms der Haut. Moglichkeiten Drenzen Alternativen. Fortschr Med 1996; 114: 251-256.
  40. Gropper C.A., Stiller M.J., Shupak J.L. et al. Diagnostic high-resolution ultrasound in dermatology. Int J Dermatol- 1993; 32: 234-250.
  41. Happe M., Freitag M., Stucket M. et al. Hochauflosende 20 MHz-Sonographie in der Dermatologie zur nicht invasiven Darstellung maligner Melanome. Z Arztl Fortbild Qualitatssich 1997; 91: 347-353.
  42. Harland C.C., Bamber J.C., Gusterson B.A., et al. High frequency, high resolution B-scan ultrasound in the assessment of skin tumours. Br J Dermatol 1993; 128: 525-532.
  43. Безуглый А.П., Ахмедова Л.Е., Эйри А.М. и др. Ультразвуковое исследование кожи, принципы и возможности метода. Альманах клинической медицины, 2006, том IX. Пролиферативные заболевания кожи/ под общей редакцией В.И. Шумского. М: МОНИКИ, 2006: 20-23.
  44. Безуглый А.П., Бикбулатова Н.Н., Шугинина Е.А. и др. Ультразвуковое исследование кожи в практике врача-косметолога. Вестн. дерматол. и венерол., 2011; 3: 142-152.
  45. El-Gammal S., Altmeyer P., Auer T. et al. Der Stellenwert der 20, 50 und 100 MHz Sonographie in der Dermatologie. Akt Dermatol 1995; 21: 11-21.
  46. El-Gammal S., Auer T., Hoffman K. et al. Highresolution ultrasound examination of the epidermis. In: Serup J, Jemec GBE, eds. Handbook of non-invasive methods and the skin. Boca Raton: CRC Press, 1995: 125-32.
  47. Василевская Е.А., Иванова Е.В, Кузьмина Т.С. и др. Использование высокочастотной ультразвуковой аппаратуры для исследования кожи в норме и при патологии. Эксперим. и клин. дерматокосметол., 2005; 1: 33-37.
  48. Jemec G.B., Gniadecka M., Ulrich J. Ultrasound in dermatology. Part I. High frequency ultrasound. Eur J Dermatol 2000 Aug; 10(6): 492-7.
  49. Корчагина Е.А., Иванова Е.В., Потекаев Н.Н., Ткаченко С.Б. Химический пилинг. Ультразвуковое сканирование в оценке метода. Эксперим. и клин. дерматокосметол., 2005; 1: 5.
  50. Gniadecka M., Jemec G. Quantitative evaluation of cronological ageing and photoageing in vivo: studies on skin echogenicity and thickness. Br J Dermatol 1998(Nov); 139(5): 815-21.
  51. Василевская А.Е., Кузьмина Т.С., Потекаев Н.Н. и др. Клинические исследования, оценка эффективности фототерапии псориаза с использованием метода ультразвукового сканирования. Эксперим. и клин. дерматокосметол., 2005; 5: 7.
  52. Hu D., Phan T.T., Cherry G.W. et al. Dermal oedema assessed by high frequency ultrasound in venous leg ulcers. Br J Dermatol 1998 May; 138(5): 815-20.
  53. Безуглый А.П., Ахмедова Л.Е., Потекаев Н.Н. и др. Ультразвуковое сканирование кожи в практике врача-дерматокосметолога. Эксперим. и клин. дерматокосметол., 2006; 6: 42-48.
  54. Desai T.D., Desai A.D., Horowitz D.C. et al. The use of high-frequency ultrasound in the evaluation of superficial and nodular basal cell carcinomas. Dermatol Surg 2007 Oct; 33(10): 1220-7.
  55. Ulrich J., Petereit S., Gollnick H. Präoperative sonographische Melanomdiagnostik - Vergleich von 7.5 und 20-MHz-Sonographie. Ultraschall Med 1999; 20: 197-200.
  56. Hoffmann K., Happe M., Schüller S. et al. Stellenwert der 20-MHz-Sonographie des malignen Melanoms und pigmentierter Läsionen in der Routinediagnostik. Ultraschall Med 1999; 20: 104-9.
  57. Abramovits W., Stevenson L.C. Changing paradigms in dermatology:new ways to examine the skin using noninvasive imaging methods. Clin Dermatol 2003; 21: 353-358.
  58. Rajadhyaksha M., Gonza´lez S., Zavislan J. et al. In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison to histology. J Invest Dermatol 1999; 113: 293-303.
  59. Gonzalez S. Confocal Reflectance Microscopy in Dermatology: Promise and Reality of Non- Invasive Diagnosis and Monitoring. Actas Dermosifiliogr 2009; 100 (2): 59-69.
  60. Minsky M. Microscopy apparatus. US Patent No. 3013467; 1957.
  61. Rajadhyaksha, M., Gonzalez, S. and Zavislan, J.M. Detectability of contrast agents for confocal reflectance imaging of skin and microcirculation. J. Biomed. Opt. 9, 323-331 (2004).
  62. Rajadhyaksha M., Zavislan J.M. Confocal laser microscope images tissue in vivo. Laser Focus World. 1997; 33: 119-127.
  63. Rajadhyaksha M. Zavislan J.M. Confocal reflectance microscopy of unstained tissue in vivo. Retinoids 1998; 14: 26-30.
  64. Rajadhyaksha M., Gonzales S., Zavislan J.M. et al. Video-rate confocal scanning laser microscope for imaging human tissues in vivo. J Invest Dermatol 1999; 38: 1-12.
  65. Eichert S., Möhrle M., Breuninger H. et al. Diagnosis of cutaneous tumors with in vivo confocal laser scanning microscopy. JDDG 2010; 8: 400-410.
  66. Gerger A., Hofmann-Wellenhof R., Samonigg H. et al. In vivo confocal laser scanning microscopy in the diagnosis of melanocytic skin tumours. Br J Dermatol 2009; 160: 475-81.
  67. Guitera P., Pellacani G., Crotty K.A. et al. The Impact of In Vivo Reflectance Confocal Microscopy on the Diagnostic Accuracy of Lentigo Maligna and Equivocal Pigmented and Nonpigmented Macules of the Face. J Invest Dermatol advance online publication, 15 April 2010; doi: 10.1038/jid.2010.84.
  68. Pellacani G., Longo C., Malvehy J. et al. In vivo confocal microscopic and histopathologic correlations of dermoscopic features in 202 melanocytic lesions. Arch Dermatol 2008 Dec; 144(12): 1597-608.
  69. Ulrich M., Maltusch A., Rius-Diaz F. et al. Clinical applicability of in vivo reflectance confocal microscopy for the diagnosis of actinic keratoses. Dermatol Surg 2008 May; 34(5): 610-9.
  70. Ulrich M., Krueger-Corcoran D., Roewert-Huber J. et al. Reflectance confocal microscopy for noninvasive monitoring of therapy and detection of subclinical actinic keratoses. Dermatology 2009 (Epub ahead of print).
  71. Agero A.L., Busam K.J., Benvenuto-Andrade C. et al. Reflectance confocal microscopy of pigmented basal cell carcinoma. J Am Dermatol 2006 Apr; 54 (4): 638-43.
  72. Nori S., Rius-Díaz F., Cuevas J. et al. Sensitivity and specificity of reflectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: a multicenter study. J Am Acad Dermatol 2004 Dec; 51 (6): 923-30.
  73. Ahlgrimm-Siess V., Horn M., Koller S. et al. Monitoring efficacy of cryotherapy for superficial basal cell carcinomas with in vivo reflectance confocal microscopy: a preliminary study. J Dermatol Sci 2009; 53: 60-4.
  74. Horn M., Gerger A., Koller S. et al. The use of confocal laser-scanning microscopy in microsurgery for invasive squamous cell carcinoma. Br J Dermatol 2007; 156 (1): 81-84.
  75. Gonzalez S., Rajakhyaksha M., Rubinstein G. et al. Characterization of psoriasis in vivo by reflectance confocal microscopy. J Med 1999; 30: 337-356.
  76. Astner S., Gonzalez E., Cheung A.C. et al. Noninvasive evaluation of the kinetics of allergic and irritant contact dermatitis. J Invest Dermatol 2005; 124, 351-359.
  77. Swindells K., Burnett N., Rius-Diaz F. et al. Reflectance confocal microscopy may differentiate acute allergic and irritant contact dermatitis in vivo. J Am Acad Dermatol 2004; 50: 220-228.
  78. Gonzalez, S., Rajadhyaksha M., Gonzalez-Serva A. et al. Confocal reflectance imaging of folliculitis in vivo. Correlation of confocal imaging to routine histology. J Cut Pathol 1999; 26: 201-205.
  79. Goldgeier M., Fox C.A., Muhlbauer J.E. Immediate non-invasive diagnosis of herpes virus by confocal scanning laser microscopy. J Am Acad Dermatol 2002; 46: 783-785.
  80. Hongcharu W., Dwyer P., Gonzalez S. et al. Confirmation of onychomychosis by confocalmicroscopy. J Am Acad Dermatol 2000; 42: 214-216.

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Copyright (c) 2011 Shtirshnayder Y.Y., Michenko A.V., Katunina O.R., Zubarev A.R., SHTIRSHNEIDER Y.Y., MICHENKO A.V., KATUNINA O.R., ZUBAREV A.R.

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