The possibilities of using retinol palmitate in the systemic treatment of generalized hereditary keratinization disorders

Cover Page


Cite item

Full Text

Abstract

Hereditary ichthyosis is a group of generalized hereditary keratinization disorders characterized by general dryness of the skin, peeling, hyperkeratosis and often erythroderma. These manifestations are caused by mutations in genes mainly involved in the formation of the skin barrier. Hereditary ichthyosis is divided into syndromic and non-syndromic. Nonsyndromic ichthyoses include: vulgar ichthyosis, recessive X-linked ichthyosis, autosomal recessive congenital ichthyosis, keratinopathic ichthyosis and other forms. At present, the best result for achieving clinical remission has been established with oral retinoids: retinol palmitate, isotretinoin (1st generation of retinoids) and acitretin (2nd generation of retinoids). The ability of retinol palmitate to regulate keratinization processes, strengthen the epidermal barrier and have an antioxidant effect is used in the treatment of generalized hereditary keratinization disorders. Medium and high therapeutic doses (2000–10 000 IU/kg/day) are used in the treatment. The prescribed dose of retinol palmitate differs in various nosological forms of ichthyosis, and depends on the severity of the pathological process, the age and weight of the patient, which must be taken into account when prescribing therapy to obtain the best result. It should be noted that clinical manifestations mainly regress at doses that do not lead to the appearance of signs of toxicity of the drug. The methods of retinol palmitate treatment of ichthyosis and ichthyosiform erythroderma are described.

Full Text

 

 

×

About the authors

Stanislava Yu. Petrova

Joint-stock company Pharmaceutical enterprise «Retinoids»;
Mechnikov Research Institute of Vaccines and Sera.

Email: petrovastanislava@yandex.ru
ORCID iD: 0000-0003-3034-0148
SPIN-code: 7268-6944

PhD of Medical Sciences, the opinion leader of the medical department of Joint-stock company Pharmaceutical enterprise «Retinoids»opinion;  Senior Researcher at the laboratory of allergens

Russian Federation, 5a Maly Kazenny Pereulok, 105064, Moscow; 1a Svobody str., Ceramic microdistrict, 143983, Moscow region, Balashikha

Vera I. Albanova

Moscow Regional Research and Clinical Institute (MONIKI)

Author for correspondence.
Email: albanova.v@gmail.com
ORCID iD: 0000-0001-8688-7578
SPIN-code: 5548-5359

Dr. Sci. (Med.); Professor of the Department of Dermatovenerology and Dermatooncology

Russian Federation, 61/2, Shepkina str., 129110, Moscow

References

  1. Onnis G, Chiaverini C, Hickman G, Dreyfus I, Fischer J, Bourrat E, et al. Alitretinoin reduces erythema in inherited ichthyosis. Orphanet J Rare Dis. 2018;13(1):46. doi: 10.1186/s13023-018-0783-9
  2. Ихтиоз. Клинические рекомендации. Российское общество дерматовенерологов и косметологов. 2020 [Ihtioz. Klinicheskie rekomendacii. (Ichthyosis. Clinical recommendations.) Rossijskoe obshhestvo dermatovenerologov i kosmetologov. 2020. (In Russ.)] https://cnikvi.ru/docs/clinic_recs/klinicheskie-rekomendatsii-2019-2020/files/Ихтиоз%2008.10.2020.docx (Accessed 16 October 2022).
  3. Takeichi T, Akiyama M. Inherited ichthyosis: non-syndromic forms. J Dermatol. 2016;43(3):242–251. doi: 10.1111/1346-8138.13243
  4. Ноздрин В.И., Конь И.Я., Гузев К.С., Волков Ю.Т. Фармакологическая активность ретинола пальмитата. Ретиноиды. 2014;(33):12–18 [Nozdrin VI, Kon’ IJa, Guzev KS, Volkov JuT. Pharmacological activity of retinol palmitate. Retinoidy. 2014;(33):12–18. (In Russ.)]
  5. Матушевская Е.В., Свирщевская Е.В. Современные возможности применения системных ретиноидов в дерматологической практике (обзор зарубежной литературы). Клиническая дерматология и венерология. 2018;17(5):18–23 [Matushevskaja EV, Svirshchevskaja EV. Modern possibilities of using systemic retinoids in dermatological practice (review of international literature). Klinicheskaja dermatologija i venerologija. 2018;17(5):18–23. (In Russ.)] doi: 10.17116/klinderma20181705118
  6. Zaenglein AL, Levy ML, Stefanko NS, Benjamin LT, Bruckner AL, Choate K, et al. Use of retinoids in ichthyosis work group. Consensus recommendations for the use of retinoids in ichthyosis and other disorders of cornification in children and adolescents. Pediatr Dermatol. 2021;38(1):164–80. doi: 10.1111/pde.14408
  7. Conaway HH, Henning P, Lerner UH. Vitamin A metabolism, action, and role in skeletal homeostasis. Endocr Rev. 2013;34(6):766–797. doi: 10.1210/er.2012-1071
  8. Ноздрин В.И., Белоусова Т.А., Альбанова В.И., Лаврик О.И. Гистоформакологические исследования кожи. М.: Ретиноиды; 2006. C. 55–298 [Nozdrin VI, Belousova TA, Al’banova VI, Lavrik OI. Gistoformakologicheskie issledovanija kozhi. (Histopharmacological studies of the skin.) Moscow: Retinoidy; 2006. Р. 55–298. (In Russ.)]
  9. Törmä H, Bergström A, Ghiasifarahani G, Berne B. The effect of two endogenous retinoids on the mRNA expression profile in human primary keratinocytes, focusing on genes causing autosomal recessive congenital ichthyosis. Arch Dermatol Res. 2014;306(8):739–747. doi: 10.1007/s00403-014-1476-4
  10. Lee DD, Stojadinovic O, Krzyzanowska A, Vouthounis C, Blumenberg M, Tomic-Canic M. Retinoid-responsive transcriptional changes in epidermal keratinocytes. J Cell Physiol. 2009;220(2):427–439. doi: 10.1002/jcp.21784
  11. Yaar M, Stanley JR, Katz SI. Retinoic acid delays the terminal differentiation of keratinocytes in suspension culture. J Invest Dermatol. 1981;76(5):363–366. doi: 10.1111/1523-1747.ep12520026
  12. Opinion of the scientific committee on consumer safety (SCCS) — final version of the opinion on vitamin A (retinol, retinyl acetate and retinyl palmitate) in cosmetic products. Regul Toxicol Pharmacol. 2017;84:102–104. doi: 10.1016/j.yrtph.2016.11.017
  13. Мордовцев В.Н., Альбанова В.И., Иванова И.А., Прохоров А.Ю., Сонин Д.Б., Васильчиков В.Г., и др. Ретинола пальмитат в лечении больных с нарушениями кератинизации. Ретиноиды. 2014;(33):19–26 [Mordovtsev VN, Al’banova VI, Ivanova IA, Prohorov AJu, Sonin DB, Vasil’chikov VG, et al. Retinol palmitate in the treatment of patients with keratinization disorders. Retinoidy. 2014;(33):19–26. (In Russ.)]
  14. Carazo A, Macáková K, Matoušová K, Krčmová LK, Protti M, Mladěnka P. Vitamin A update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity. Nutrients. 2021;13(5):1703. doi: 10.3390/nu13051703
  15. Griffiths CE, Rosenthal DS, Reddy AP, Elder JT, Astrom A, Leach K, et al. Short-term retinoic acid treatment increases in vivo, but decreases in vitro, epidermal transglutaminase-K enzyme activity and immunoreactivity. J Invest Dermatol. 1992;99(3):283–238. doi: 10.1111/1523-1747.ep12616626
  16. Ноздрин К.В., Коколина В.Ф., Картелищев А.В., Альбанова В.И., Родионова Г.М. Технологии системной ретинолотерапии в педиатрической практике. Методические рекомендации. М.: Ретиноиды; 2016. C. 20–39 [Nozdrin KV, Kokolina VF, Kartelishchev AV, Al’banova VI, Rodionova GM. Tehnologii sistemnoj retinoloterapii v pediatricheskoj praktike. Metodicheskie rekomendacii. (Technologies of systemic retinotherapy in pediatric practice. Methodological recommendations.) Moscow: Retinoidy; 2016. Р. 20–39 (In Russ.)]. ISBN 978-5-93118-051-9
  17. Альбанова В.И. Роль наружных ретиноидов в устранении признаков старения кожи. Вестник дерматологии и венерологии. 2021;97(4):60–70 [Al’banova VI. The role of local retinoids in eliminating signs of skin aging. Vestnik dermatologii i venerologii. 2021;97(4):60–70. (In Russ.)] doi: 10.25208/vdv1220
  18. Еникеев А.Д., Комельков А.В., Аксельрод М.Е., Чевкина Е.М. Неканоническая активность ретиноевой кислоты как возможный механизм формирования резистентности злокачественных клеток к ретиноидной терапии. Российский биотерапевтический журнал. 2019;18(4):43–50 [Enikeev AD, Komel’kov AV, Aksel’rod ME, Chevkina EM. Non-canonical activity of retinoic acid as a possible mechanism of retinoid resistance in cancer therapy. Rossijskij bioterapevticheskij zhurnal. 2019;18(4):43–50. (In Russ.)] doi: 10.17650/1726-9784-2019-18-4-43-50
  19. Polcz ME, Barbul A. The role of vitamin A in wound healing. Nutr Clin Pract. 2019;34(5):695–700. doi: 10.1002/ncp.10376
  20. Shao Y, He T, Fisher GJ, Voorhees JJ, Quan T. Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo. Int J Cosmet Sci. 2017;39(1):56–65. doi: 10.1111/ics.12348
  21. Кong R, Cui Y, Fisher GJ, Wang X, Chen Y, Schneider LM, et al. A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skin. J Cosmet Dermatol. 2016;15(1):49–57. doi: 10.1111/jocd.12193
  22. Zinder R, Cooley R, Vlad LG, Molnar JA. Vitamin A and wound healing. Nutr Clin Pract. 2019;34(6):839–849. doi: 10.1002/ncp.10420
  23. Дмитренко С.В., Вернигородский С.В. Морфологическая оценка эффективности лечения ихтиоза с применением ретиноидов. Наука молодых. 2015;(2):12–32 [Dmitrenko SV, Vernygorodskij SV. Morphological evaluation of the effectiveness treatment of ichthyosis with the use of retinoids. Nauka molodyh. 2015;(2):12–32. (In Russ.)]
  24. Plikus MV, Van Spyk EN, Pham K, Geyfman M, Kumar V, Takahashi JS, et al. The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity. J Biol Rhythms. 2015;30(3):163–182. doi: 10.1177/0748730414563537
  25. Tamaru T, Hattori M, Ninomiya Y, Kawamura G, Varès G, Honda K, et al. ROS stress resets circadian clocks to coordinate pro-survival signals. PLoS One. 2013;8(12):e82006. doi: 10.1371/journal.pone.0082006
  26. Matsui MS, Pelle E, Dong K, Pernodet N. Biological rhythms in the skin. Int J Mol Sci. 2016;17(6):801. doi: 10.3390/ijms17060801
  27. Соболевская И.С., Зыкова О.С., Мяделец О.Д. Роль мелатонина в физиологии и патологии кожи. Клиническая дерматология и венерология. 2018;17(6):116–123 [Sobolevskaja IS, Zykova OS, Mjadelec OD. The role of melatonin in the physiology and pathology of the skin. Klinicheskaja dermatologija i venerologija. 2018;17(6):116–123. (In Russ.)] doi: 10.17116/klinderma201817061116
  28. Albers KM, Taichman LB. Kinetics of withdrawal from the cell cycle in cultured human epidermal keratinocytes. J Invest Dermatol. 1984;82(2):161–164. doi: 10.1111/1523-1747.ep12259726
  29. Юров И.Ю., Ворсанова С.Г., Воинова В.Ю., Чурносов М.И., Юров Ю.Б. Цитогенетические, молекулярные и клинические основы генетически обусловленных болезней. М.: Издательский дом Академии Естествознания; 2019. C. 63–67 [Jurov IJu, Vorsanova SG, Voinova VJu, Churnosov MI, Jurov JuB. Citogeneticheskie, molekuljarnye i klinicheskie osnovy geneticheski obuslovlennyh boleznej. (Cytogenetic, molecular and clinical bases of genetically determined diseases.) Moscow: Izdatel'skij dom Akademii Estestvoznanija; 2019. Р. 63–67 (In Russ.)] doi: 10.17513/np.351
  30. Majmundar VD, Baxi K. Hereditary and acquired ichthyosis vulgaris. Treasure Island: StatPearls Publishing; 2022. https://www.ncbi.nlm.nih.gov/books/NBK562318 (Accessed 16 October 2022).
  31. Crane JS, Paller AS. X-Linked Ichthyosis. Treasure Island: StatPearls Publishing; 2022. https://www.ncbi.nlm.nih.gov/books/NBK448149 (Accessed 16 October 2022).
  32. Elias PM, Williams ML, Choi EH, Feingold KR. Role of cholesterol sulfate in epidermal structure and function: lessons from X-linked ichthyosis. Biochim Biophys Acta. 2014;1841(3):353–361. doi: 10.1016/j.bbalip.2013.11.009
  33. Richard G. Autosomal Recessive Congenital Ichthyosis. Seattle: University of Washington; 2017. P. 1993–2022.
  34. Patro N, Panda M, Mohanty PK. Congenital ichthyosiform erythroderma: a rare neonatal dermatoses responding to acitretin. Indian J Pharmacol. 2019;51(5):343–345. doi: 10.4103/ijp.IJP_124_17
  35. DiGiovanna JJ, Bale SJ. Clinical heterogeneity in epidermolytic hyperkeratosis. Arch Dermatol. 1994;130(8):1026–1035.
  36. Rice AS, Crane JS. Epidermolytic hyperkeratosis. Treasure Island: StatPearls Publishing; 2022. https://www.ncbi.nlm.nih.gov/books/NBK544323 (Accessed 16 October 2022).
  37. Peter Rout D, Nair A, Gupta A, Kumar P. Epidermolytic hyperkeratosis: clinical update. Clin Cosmet Investig Dermatol. 2019;12:333–344. doi: 10.2147/CCID.S166849

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. 6 years old girl. Vulgar ichthyosis: а — marked desquamation of the legs; б — folding and deepening of the skin lines on the palms. Author's observation. The informed consent of the child's parents to the publication of his image has been obtained

Download (698KB)
Indexing metadata
3. Fig. 2. 26 years old man. X-linked recessive ichthyosis: а — small-scale peeling of the back; б — dark scales on neck, face free from scaling. Author's observation. The patient's informed consent to the publication of his image was obtained

Download (841KB)
Indexing metadata
4. Fig. 3. 26 years old man. Lamellar ichthyosis: а — large saucer-shaped scales on the back; б — pronounced dryness of the skin, medium and large-scale peeling; в — deformation of the auricles, peeling of the face and scalp, sparse hair; г — peeling of the face, ectropion. Author's observation. The patient's informed consent to the publication of his image was obtained

Download (1MB)
Indexing metadata
5. Fig. 4. 1 year old boy. Non-bullous congenital ichthyosiform erythroderma: а — erythroderma, finely scaled peeling, larger scales on the hands; б — erythroderma, finely scaled peeling on foot. Author's observation. The informed consent of the child's parents to the publication of his image has been obtained

Download (806KB)
Indexing metadata
6. Fig. 5. 6 year old girl. Bullous congenital ichthyosiform erythroderma: а — horny layers of gray color on the body; б — horny layers on the hands, areas of apparently healthy skin in places where there were blisters before; в — horny layers in the form of concentric clusters on the elbows; г — massive horny layers on the feet. Author's observation. The informed consent of the child's parents to the publication of his image has been obtained

Download (1MB)
Indexing metadata

Copyright (c) 2023 Petrova S.Y., Albanova V.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies