Современные подходы к лечению андрогенетической алопеции

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Большинство случаев выпадения волос обусловлено андрогенетической алопецией (АГА). Для европеоидной расы вероятность появления этого заболевания достигает 80% для мужчин и 42% для женщин. Золотой стандарт лечения АГА включает миноксидил и/или финастерид. Эффективность этих препаратов умеренная, рост волос наблюдается далеко не у всех пациентов. Более того, оба средства имеют значимые побочные эффекты. Для лечения АГА у женщин может использоваться только миноксидил. В работе анализируются современные представления о молекулярных механизмах патогенеза и методах лечения АГА с их ограничениями и недостатками. Освещены перспективные подходы к лечению АГА, способные превзойти по эффективности и безопасности миноксидил и финастерид, их сегодняшнее состояние и перспективы. Обсуждаются средства на основе факторов роста и цитокинов, ингибиторы 5а-редуктазы местного нанесения, антагонисты андрогеновых рецепторов, активаторы Wnt-сигнального пути, аналоги и антагонисты простагландинов, а также процедура плазмотерапии обогащенной тромбоцитами плазмой.

Об авторах

В. К. Карнаухов

ФГБОУ ВО «Московский государственный университет им. М. В. Ломоносова»

Автор, ответственный за переписку.
Email: vadim-karnaukhov@mail.ru
Россия

А. А. Лукьянова

Школа стилистов ПЕРСОНА

Email: noemail@neicon.ru
Россия

М. И. Лукашина

ФГБУН «Институт биологии гена» РАН; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава России

Email: noemail@neicon.ru
Россия

Е. С. Воробьёва

ФГБУН «Институт биологии гена» РАН

Email: noemail@neicon.ru
Россия

И. М. Афанасов

ООО «ДжиЭф Групп»

Email: noemail@neicon.ru
Россия

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© Карнаухов В.К., Лукьянова А.А., Лукашина М.И., Воробьёва Е.С., Афанасов И.М., 2017

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