Estimation of clinical efficiency of topical combination therapy patients with pyoderma complicated eczema

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Abstract

The results of direct open-label study of efficacy and portability of combination therapy with topical betamethasone dipropionate and mupirocin are presented. Material and methods. Twenty two patients with pyoderma complicated eczema were treated with ointment for external use (betamethasone dipropionate and mupirocin) 2 times a day for 14 days. Clinical efficacy was assessed by the reliability decrease of index EASI and dermatological symptoms scale index (DSSI). Results. Clinical convalescense was achieved in all patients by the 14th day of therapy. There was a statistically significant decrease in the indices EASI, DSSI. Portability were well. Conclusion. Our study results showed clinical efficacy and portability of topical combination therapy of betamethasone dipropionate and mupirocin in patients with pyoderma complicated eczema.

About the authors

V. A. Okhlopkov

Omsk State Medical Academy

Author for correspondence.
Email: ochlopkov@omsk-osma.ru
Russian Federation

E. YU. Zubareva

Omsk State Medical Academy

Email: noemail@neicon.ru
Russian Federation

YU. A. Novikov

Omsk State Medical Academy

Email: noemail@neicon.ru
Russian Federation

M. S. Sukach

Omsk State Medical Academy

Email: noemail@neicon.ru
Russian Federation

T. V. Repina

Clinical dermatovenerologic dispensary

Email: noemail@neicon.ru
Russian Federation

I. YU. Lekavitchus

Clinical dermatovenerologic dispensary

Email: noemail@neicon.ru
Russian Federation

N. V. Grankina

Clinical dermatovenerologic dispensary

Email: noemail@neicon.ru
Russian Federation

References

  1. Izadpanah A., Gallo R.L. Antimicrobial peptides. J Am Acad Dermatol 2005; 52 (3Pt1): 381-390.
  2. Wolff K., Goldsmith L.A., Katz S.I. et al. Fitzpatrick’s dermatology in general medicine: v 3 t. Per. s angl.; obshch. red. akad. A.A. Kubanovoy. M.: Izd-vo Panfilova; BINOM, Laboratoriya znaniy, 2012; T.3: s. 1841-1847.
  3. Bakulev A.L., Kravchenya S.S., Murashkin N.N. et al. Microbial eczema: new potential of combined topical treatment. Vestn Dermatol Venerol 2011; 6: 98-104
  4. Sohn A., Francel A., Patel R.V., Goldenberg G. Eczema. Mt Sinai J Med 2011; 78 (5): 730-739.
  5. Chang C., Keen C.L., Gersbwin M.E. Treatment of eczema. Clin Rev Allergy Immunol. 2007; 35 (3): 204-225. Литература
  6. Hoare C., Li Wan Po A., Williams H. Systemic review of treatments for atopic eczema. Health Technol Assess 2000; 4 (37): 1-191.
  7. Okovityy S.V., Ivkin D.Yu. Mupirotsin: klinicheskoe primenenie. Consilium medicum 2011; (4): 3-10.
  8. Sutherland R., Boon R.J., Griffin K.E. et al. Antibacterial activity of mupirocin (pseudomonic acid) a new antibiotic for topical use. Antimicrob Agent Chemother 1985; 27 (4): 495-498.
  9. Leyden J.J. Mupirocin - a new topical antibiotic. Semin Dermatol 1987; (6): 48-54.
  10. Pappa K.A. The clinical development of mupirocin. J Am Acad Dermatol 1990; 22 (5 Pt 1): 873-879.
  11. Bogdanovich T.M., Strachunskiy L.S. Mupirotsin: unikal'nyy antibiotik dlya mestnogo primeneniya. Clinical Microbiology and Antimicrobial Therapy 1999; 1 (1): 57-65
  12. Prakticheskoe rukovodstvo po antiinfektsionnoy khimioterapii. Pod red L.S.Strachunskogo, Yu.B. Belousova, S.N. Kozlova, M.: NIIAKh SGMA, 2002: 586 S.
  13. Annigeri R., Conly J., Vas S. at al. Emergence of mupiricin-resistant Staphylococcus aureus in chronic peritoneal dialysis patients using mupirocin prophylaxis to prevent exit-site infection. Perit Dial Int 2001; 21 (6): 554-559.
  14. Vas S.I., Conly J., Bargman J.M., Oveopoulos D.G. Resistence to mupirocin no indication of it to date while using mupirocin ointment for prevention of Staphylococcus aureus exit-site infections in peritoneal dialysis patients. Perit Dial Int 1999; 19 (4): 313-314.
  15. Savant S., Janaki V.R., Mittal R.R. et al. Evaluation of safety and efficacy of supirocin-B (mupirocin 2% + betamethasone dipropionate 0.05%) in infected dermatosis - a post marketing study. J Indian Med Assoc 2000; 90 (4): 194-195.

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Copyright (c) 2014 Okhlopkov V.A., Zubareva E.Y., Novikov Y.A., Sukach M.S., Repina T.V., Lekavitchus I.Y., Grankina N.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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