Cephalosporins of the third generation for the treatment of gonorrhea

Abstract


The article presents the data on antibiotic resistance and N. gonorrhoeae mechanisms for developing resistance to
antimicrobial drugs belonging to different pharmacologic groups and applied for causal treatment of gonorrhea. The
article proves the key problem related to the treatment of gonococcal infection in Russia lies in the prevalence of strains
being resistant to most of the antibacterial drugs that used to be applied in the clinical practice on a broad scale and
efficiently. So, cephalosporins of the third generation are presently the only drug type that N. gonorrhoeae remains
sensitive to. Their application ensures the maximum efficacy against the gonococcal infection. According to the presentday
international recommendations complying with the WHO criteria as well as accumulated experience, cefixime, a drug
belonging to cephalosporins of the third generation, can be a drug of choice for the antibacterial therapy of gonorrhea
along with ceftriaxon.

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