Changes in the hormonal status of patients with focal psoriasis vulgaris


Cell differentiation affections substantiate the urgency of the problem related to studying mutual impact of primary or
secondary endocrine pathology and hyperproliferative skin diseases. Psoriasis is one of the most demonstrative pathologies
for this study for being a prevalent and genetically predetermined disease with a chronic and relapsing course characterized
by increased proliferation of keratinocytes, abnormal differentiation process of epidermis cells, inflammatory and immune
changes in derma, and dyshormonal disorders are among factors triggering the disease. The study involved 61 male patients.
The study group (n = 43) comprised patients with circumscribed psoriasis vulgaris at the progression stage while the control
group (n = 18) comprised healthy people. Blood concentration of such hormones as prolactin and cortisone was assessed
by the immune-enzyme assay method. An increased cortisone concentration in patients suffering from psoriasis vs. control
group was revealed. Psoriatic patients tend to have an increased prolactin level.


  1. Берштейн Л.М. Онкоэндокринология: Традиции, современность и перспективы. СПб: Наука, 2004.
  2. Анисимов В.Н. Старение и канцерогенез. Русский журнал «СПИД, рак и общественное здоровье», 2009; 13 (1): 64-87.
  3. Берштейн Л.М., Порошина Н.Ю., Васильев Д.А. и др. Оценка соотношения гормональных и прогенотоксических эффектов эстрогенов и глюкозы у онкологических больных. Бюлл. экспер. биол., 2010; 150 (8): 208-211.
  4. Берштейн Л.М. Феноменальный эстроген и эстрогенный феномен. Природа, 2003; 9: 24-29.
  5. Isla A., Alvarez F., Bonzalez A. et al. Brain tumor and pregnancy. Obstetrics & Gynecology 1997; 89: 19-23.
  6. Kanda N., Watanabe S. Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes. Endocrinology 2007; 148: 2317-2325.
  7. Uchiyama N., Yamamoto A., Kameda K. et al. The activity of fatty acid synthase of epidermal keratinocytes is regulated in the lower stratum spinousum and the stratum basale by local inflammation rather than by circulating hormones. J Dermatol Sci 2000; 24: 134-141.
  8. Копытова Т.В., Абалихина Е.П., Щелчкова Н.А. Значение определения липидов в биологических субстратах для оценки обменных процессов при псориазе. Клин. лаб. диагностика, 2007; 1: 20-23.
  9. Augey F., Dissard C., Normand I. et al. Generalized pustular psoriasis (von Zumbusch) following iatrogenic hypocortisolism. Eur J Dermatol 2004; 14: 415-417.
  10. Беловол А.Н. Состояние некоторых оценочных показателей гормонального статуса у больных с псориатической патологией. Буковинський медичний вiсник, 2010; 14 (2): 20-23.
  11. Бобынцев И.И., Левшин Р.Н., Силина Л.В. Нервные и эндокринные механизмы псориатической болезни. Курский научно-практический вестник «Человек и его здоровье», 2007; 2: 80-86.
  12. Nickoloff B.J., Micra P., Morhenn V.B. Hypophyseal hormones in psoriasis. BJD 1987; 116 (1): 15-20.



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Copyright (c) 2011 Vasil'ev A.G., Zaslavskiy D.V., Trashkov A.P., Kravtsova A.A., Kazikhanova S.R., Khayrutdinov V.R., Khvedelidze M.G., VASILIYEV A.G., ZASLAVSKY D.V., TRASHKOV A.P., KRAVTSOVA A.A., KAZIKHANOVA S.R., KHAIRUTDINOV V.R., KHVEDELIDZE M.G.

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